eF-site ID 1o9s-B PDB Code 1o9s Chain B click to enlarge Title Crystal structure of a ternary complex of the human histone methyltransferase SET7/9 Classification TRANSFERASE Compound HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-4 SPECIFIC Source Homo sapiens (Human) (Q16776) Sequence B:  GVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALY GKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKS TSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAV GPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVID VPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPI KCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVE LKAFQATQQK Description Functional site 1) chain B residue 226 type sequence A description BINDING SITE FOR RESIDUE SAH B1367 source : AC2 2) chain B residue 228 type sequence E description BINDING SITE FOR RESIDUE SAH B1367 source : AC2 3) chain B residue 265 type sequence N description BINDING SITE FOR RESIDUE SAH B1367 source : AC2 4) chain B residue 293 type sequence H description BINDING SITE FOR RESIDUE SAH B1367 source : AC2 5) chain B residue 294 type sequence K description BINDING SITE FOR RESIDUE SAH B1367 source : AC2 6) chain B residue 296 type sequence N description BINDING SITE FOR RESIDUE SAH B1367 source : AC2 7) chain B residue 297 type sequence H description BINDING SITE FOR RESIDUE SAH B1367 source : AC2 8) chain B residue 335 type sequence Y description BINDING SITE FOR RESIDUE SAH B1367 source : AC2 9) chain B residue 352 type sequence W description BINDING SITE FOR RESIDUE SAH B1367 source : AC2 10) chain B residue 356 type sequence E description BINDING SITE FOR RESIDUE SAH B1367 source : AC2 11) chain B residue 245 type catalytic sequence Y description 350 source MCSA : MCSA2 12) chain B residue 293 type catalytic sequence H description 350 source MCSA : MCSA2 13) chain B residue 297 type catalytic sequence H description 350 source MCSA : MCSA2 14) chain B residue 305 type catalytic sequence Y description 350 source MCSA : MCSA2 15) chain B residue 335 type catalytic sequence Y description 350 source MCSA : MCSA2 16) chain B residue 226 type MOD_RES sequence A description Citrulline; alternate => ECO:0000269|PubMed:16567635 source Swiss-Prot : SWS_FT_FI1 17) chain B residue 296 type MOD_RES sequence N description Citrulline; alternate => ECO:0000269|PubMed:16567635 source Swiss-Prot : SWS_FT_FI1 18) chain B residue 297 type MOD_RES sequence H description Citrulline; alternate => ECO:0000269|PubMed:16567635 source Swiss-Prot : SWS_FT_FI1 19) chain B residue 335 type MOD_RES sequence Y description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 source Swiss-Prot : SWS_FT_FI3 20) chain B residue 245 type MOD_RES sequence Y description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 source Swiss-Prot : SWS_FT_FI3 21) chain B residue 256 type MOD_RES sequence D description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 source Swiss-Prot : SWS_FT_FI3 22) chain B residue 266 type MOD_RES sequence T description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 source Swiss-Prot : SWS_FT_FI3 23) chain B residue 317 type MOD_RES sequence K description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 source Swiss-Prot : SWS_FT_FI3

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