eF-site ID 1o9s-ABKL
PDB Code 1o9s
Chain A, B, K, L

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Title Crystal structure of a ternary complex of the human histone methyltransferase SET7/9
Classification TRANSFERASE
Compound HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-4 SPECIFIC
Source Homo sapiens (Human) (Q16776)
Sequence A:  GVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALY
GKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKS
TSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAV
GPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVID
VPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPI
KCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVE
LKAFQATQQK
B:  GVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALY
GKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKS
TSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAV
GPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVID
VPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPI
KCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVE
LKAFQATQQK
K:  ARTXQTARKY
L:  ARTXQT
Description


Functional site

1) chain A
residue 226
type
sequence A
description BINDING SITE FOR RESIDUE SAH A1367
source : AC1

2) chain A
residue 228
type
sequence E
description BINDING SITE FOR RESIDUE SAH A1367
source : AC1

3) chain A
residue 265
type
sequence N
description BINDING SITE FOR RESIDUE SAH A1367
source : AC1

4) chain A
residue 293
type
sequence H
description BINDING SITE FOR RESIDUE SAH A1367
source : AC1

5) chain A
residue 294
type
sequence K
description BINDING SITE FOR RESIDUE SAH A1367
source : AC1

6) chain A
residue 296
type
sequence N
description BINDING SITE FOR RESIDUE SAH A1367
source : AC1

7) chain A
residue 297
type
sequence H
description BINDING SITE FOR RESIDUE SAH A1367
source : AC1

8) chain A
residue 335
type
sequence Y
description BINDING SITE FOR RESIDUE SAH A1367
source : AC1

9) chain A
residue 352
type
sequence W
description BINDING SITE FOR RESIDUE SAH A1367
source : AC1

10) chain A
residue 356
type
sequence E
description BINDING SITE FOR RESIDUE SAH A1367
source : AC1

11) chain K
residue 4
type
sequence X
description BINDING SITE FOR RESIDUE SAH A1367
source : AC1

12) chain B
residue 226
type
sequence A
description BINDING SITE FOR RESIDUE SAH B1367
source : AC2

13) chain B
residue 228
type
sequence E
description BINDING SITE FOR RESIDUE SAH B1367
source : AC2

14) chain B
residue 265
type
sequence N
description BINDING SITE FOR RESIDUE SAH B1367
source : AC2

15) chain B
residue 293
type
sequence H
description BINDING SITE FOR RESIDUE SAH B1367
source : AC2

16) chain B
residue 294
type
sequence K
description BINDING SITE FOR RESIDUE SAH B1367
source : AC2

17) chain B
residue 296
type
sequence N
description BINDING SITE FOR RESIDUE SAH B1367
source : AC2

18) chain B
residue 297
type
sequence H
description BINDING SITE FOR RESIDUE SAH B1367
source : AC2

19) chain B
residue 335
type
sequence Y
description BINDING SITE FOR RESIDUE SAH B1367
source : AC2

20) chain B
residue 352
type
sequence W
description BINDING SITE FOR RESIDUE SAH B1367
source : AC2

21) chain B
residue 356
type
sequence E
description BINDING SITE FOR RESIDUE SAH B1367
source : AC2

22) chain L
residue 4
type
sequence X
description BINDING SITE FOR RESIDUE SAH B1367
source : AC2

23) chain A
residue 245
type catalytic
sequence Y
description 350
source MCSA : MCSA1

24) chain A
residue 293
type catalytic
sequence H
description 350
source MCSA : MCSA1

25) chain A
residue 297
type catalytic
sequence H
description 350
source MCSA : MCSA1

26) chain A
residue 305
type catalytic
sequence Y
description 350
source MCSA : MCSA1

27) chain A
residue 335
type catalytic
sequence Y
description 350
source MCSA : MCSA1

28) chain B
residue 245
type catalytic
sequence Y
description 350
source MCSA : MCSA2

29) chain B
residue 293
type catalytic
sequence H
description 350
source MCSA : MCSA2

30) chain B
residue 297
type catalytic
sequence H
description 350
source MCSA : MCSA2

31) chain B
residue 305
type catalytic
sequence Y
description 350
source MCSA : MCSA2

32) chain B
residue 335
type catalytic
sequence Y
description 350
source MCSA : MCSA2

33) chain K
residue 2
type MOD_RES
sequence R
description Citrulline; alternate => ECO:0000269|PubMed:16567635
source Swiss-Prot : SWS_FT_FI1

34) chain L
residue 2
type MOD_RES
sequence R
description Citrulline; alternate => ECO:0000269|PubMed:16567635
source Swiss-Prot : SWS_FT_FI1

35) chain A
residue 297
type MOD_RES
sequence H
description Citrulline; alternate => ECO:0000269|PubMed:16567635
source Swiss-Prot : SWS_FT_FI1

36) chain B
residue 226
type MOD_RES
sequence A
description Citrulline; alternate => ECO:0000269|PubMed:16567635
source Swiss-Prot : SWS_FT_FI1

37) chain B
residue 296
type MOD_RES
sequence N
description Citrulline; alternate => ECO:0000269|PubMed:16567635
source Swiss-Prot : SWS_FT_FI1

38) chain B
residue 297
type MOD_RES
sequence H
description Citrulline; alternate => ECO:0000269|PubMed:16567635
source Swiss-Prot : SWS_FT_FI1

39) chain K
residue 3
type MOD_RES
sequence T
description Phosphothreonine; by HASPIN and VRK1 => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:31527692
source Swiss-Prot : SWS_FT_FI2

40) chain L
residue 3
type MOD_RES
sequence T
description Phosphothreonine; by HASPIN and VRK1 => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:31527692
source Swiss-Prot : SWS_FT_FI2

41) chain K
residue 4
type MOD_RES
sequence X
description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI3

42) chain B
residue 335
type MOD_RES
sequence Y
description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI3

43) chain L
residue 4
type MOD_RES
sequence X
description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI3

44) chain A
residue 266
type MOD_RES
sequence T
description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI3

45) chain A
residue 317
type MOD_RES
sequence K
description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI3

46) chain A
residue 335
type MOD_RES
sequence Y
description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI3

47) chain B
residue 245
type MOD_RES
sequence Y
description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI3

48) chain B
residue 256
type MOD_RES
sequence D
description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI3

49) chain B
residue 266
type MOD_RES
sequence T
description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI3

50) chain B
residue 317
type MOD_RES
sequence K
description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI3

51) chain K
residue 5
type MOD_RES
sequence Q
description 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594
source Swiss-Prot : SWS_FT_FI4

52) chain L
residue 5
type MOD_RES
sequence Q
description 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594
source Swiss-Prot : SWS_FT_FI4

53) chain K
residue 6
type MOD_RES
sequence T
description Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790
source Swiss-Prot : SWS_FT_FI5

54) chain L
residue 6
type MOD_RES
sequence T
description Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790
source Swiss-Prot : SWS_FT_FI5

55) chain K
residue 8
type MOD_RES
sequence R
description Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433
source Swiss-Prot : SWS_FT_FI6

56) chain K
residue 9
type MOD_RES
sequence K
description N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI7

57) chain K
residue 10
type MOD_RES
sequence Y
description Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588
source Swiss-Prot : SWS_FT_FI8


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