eF-site ID 1o9s-A PDB Code 1o9s Chain A click to enlarge Title Crystal structure of a ternary complex of the human histone methyltransferase SET7/9 Classification TRANSFERASE Compound HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-4 SPECIFIC Source Homo sapiens (Human) (Q16776) Sequence A:  GVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALY GKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKS TSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAV GPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVID VPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPI KCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVE LKAFQATQQK Description Functional site 1) chain A residue 226 type sequence A description BINDING SITE FOR RESIDUE SAH A1367 source : AC1 2) chain A residue 228 type sequence E description BINDING SITE FOR RESIDUE SAH A1367 source : AC1 3) chain A residue 265 type sequence N description BINDING SITE FOR RESIDUE SAH A1367 source : AC1 4) chain A residue 293 type sequence H description BINDING SITE FOR RESIDUE SAH A1367 source : AC1 5) chain A residue 294 type sequence K description BINDING SITE FOR RESIDUE SAH A1367 source : AC1 6) chain A residue 296 type sequence N description BINDING SITE FOR RESIDUE SAH A1367 source : AC1 7) chain A residue 297 type sequence H description BINDING SITE FOR RESIDUE SAH A1367 source : AC1 8) chain A residue 335 type sequence Y description BINDING SITE FOR RESIDUE SAH A1367 source : AC1 9) chain A residue 352 type sequence W description BINDING SITE FOR RESIDUE SAH A1367 source : AC1 10) chain A residue 356 type sequence E description BINDING SITE FOR RESIDUE SAH A1367 source : AC1 11) chain A residue 245 type catalytic sequence Y description 350 source MCSA : MCSA1 12) chain A residue 293 type catalytic sequence H description 350 source MCSA : MCSA1 13) chain A residue 297 type catalytic sequence H description 350 source MCSA : MCSA1 14) chain A residue 305 type catalytic sequence Y description 350 source MCSA : MCSA1 15) chain A residue 335 type catalytic sequence Y description 350 source MCSA : MCSA1 16) chain A residue 297 type MOD_RES sequence H description Citrulline; alternate => ECO:0000269|PubMed:16567635 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 266 type MOD_RES sequence T description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 source Swiss-Prot : SWS_FT_FI3 18) chain A residue 317 type MOD_RES sequence K description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 source Swiss-Prot : SWS_FT_FI3 19) chain A residue 335 type MOD_RES sequence Y description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 source Swiss-Prot : SWS_FT_FI3

Display surface Download Links