eF-site ID 1o95-ABCDEF PDB Code 1o95 Chain A, B, C, D, E, F click to enlarge Title Ternary complex between trimethylamine dehydrogenase and electron transferring flavoprotein Classification ELECTRON TRANSPORT Compound TRIMETHYLAMINE DEHYDROGENASE Source ORGANISM_SCIENTIFIC: METHYLOPHILUS METHYLOTROPHUS; Sequence A:  ARDPKHDILFEPIQIGPKTLRNRFYQVPHCIGAGSDKPGF QSAHRSVKAEGGWAALNTEYCSINPESDDTHRLSARIWDE GDVRNLKAMTDEVHKYGALAGVELWYGGAHAPNMESRATP RGPSQYASEFETLSYCKEMDLSDIAQVQQFYVDAAKRSRD AGFDIVYVYGAHSYLPLQFLNPYYNKRTDKYGGSLENRAR FWLETLEKVKHAVGSDCAIATRFGVDTVYGPGQIEAEVDG QKFVEMADSLVDMWDITIGDIAEWGEDAGPSRFYQQGHTI PWVKLVKQVSKKPVLGVGRYTDPEKMIEIVTKGYADIIGC ARPSIADPFLPQKVEQGRYDDIRVCIGCNVCISRWEIGGP PMICTQNATAGEEYRRGWHPEKFRQTKNKDSVLIVGAGPS GSEAARVLMESGYTVHLTDTAEKIGGHLNQVAALPGLGEW SYHRDYRETQITKLLKKNKESQLALGQKPMTADDVLQYGA DKVIIATGARWNTDGTNCLTHDPIPGADASLPDQLTPEQV MDGKKKIGKRVVILNADTYFMAPSLAEKLATAGHEVTIVS GVHLANYMHFTLEYPNMMRRLHELHVEELGDHFCSRIEPG RMEIYNIWGDGSKRTYRGPGVSPRDANTSHRWIEFDSLVL VTGRHSECTLWNELKARESEWAENDIKGIYLIGDAEAPRL IADATFTGHRVAREIEEANPQIAIPYKRETIAWGTPHMPG GNFKIEYKV B:  ARDPKHDILFEPIQIGPKTLRNRFYQVPHCIGAGSDKPGF QSAHRSVKAEGGWAALNTEYCSINPESDDTHRLSARIWDE GDVRNLKAMTDEVHKYGALAGVELWYGGAHAPNMESRATP RGPSQYASEFETLSYCKEMDLSDIAQVQQFYVDAAKRSRD AGFDIVYVYGAHSYLPLQFLNPYYNKRTDKYGGSLENRAR FWLETLEKVKHAVGSDCAIATRFGVDTVYGPGQIEAEVDG QKFVEMADSLVDMWDITIGDIAEWGEDAGPSRFYQQGHTI PWVKLVKQVSKKPVLGVGRYTDPEKMIEIVTKGYADIIGC ARPSIADPFLPQKVEQGRYDDIRVCIGCNVCISRWEIGGP PMICTQNATAGEEYRRGWHPEKFRQTKNKDSVLIVGAGPS GSEAARVLMESGYTVHLTDTAEKIGGHLNQVAALPGLGEW SYHRDYRETQITKLLKKNKESQLALGQKPMTADDVLQYGA DKVIIATGARWNTDGTNCLTHDPIPGADASLPDQLTPEQV MDGKKKIGKRVVILNADTYFMAPSLAEKLATAGHEVTIVS GVHLANYMHFTLEYPNMMRRLHELHVEELGDHFCSRIEPG RMEIYNIWGDGSKRTYRGPGVSPRDANTSHRWIEFDSLVL VTGRHSECTLWNELKARESEWAENDIKGIYLIGDAEAPRL IADATFTGHRVAREIEEANPQIAIPYKRETIAWGTPHMPG GNFKIEYKV C:  MKILVAVKQTAALEEDFEIRDGMDVDEDFMMYDLNEWDDF SLEEAMKIKESSDDVEVVVVSVGPDRVDESLRKCLAKGAD RAVRVWDDAAEGSDAIVVGRILTEVIKKEAPDMVFAGVQS SDQAYASTGISVASYLNWPHAAVVADLQYKPGDNKAVIRR ELEGGMLQEVEINCPAVLTIQLGINKPRYASLRGIKQAAT KPIEEVSLADIGLSANDVGAAQSMSRVRRMYIP D:  SKILVIAEHRRNDLRPVSLELIGAANGLKKSGEDKVVVAV IGSQADAFVPALSVNGVDELVVVKGSSIDFDPDVFEASVS ALIAAHNPSVVLLPHSVDSLGYASSLASKTGYGFATDVYI VEYQGDELVATRGGYNQKVNVEVDFPGKSTVVLTIRPSVF KPLEGAGSPVVSNVDAPSVQSRSQNKDYV E:  MKILVAVKQTAALEEDFEIREDGMDVDEDFMMYDLNEWDD FSLEEAMKIKESSDTDVEVVVVSVGPDRVDESLRKCLAKG ADRAVRVWDDAAEGSDAIVVGRILTEVIKKEAPDMVFAGV QSSDQAYASTGISVASYLNWPHAAVVADLQYKPGDNKAVI RRELEGGMLQEVEINCPAVLTIQLGINKPRYASLRGIKQA ATKPIEEVSLADIGLSANDVGAAQSMSRVRRMYIPE F:  SKILVIAEHRRNDLRPVSLELIGAANGLKKSGEDKVVVAV IGSQADAFVPALSVNGVDELVVVKGSSIDFDPDVFEASVS ALIAAHNPSVVLLPHSVDSLGYASSLASKTGYGFATDVYI VEYQGDELVATRGGYNQKVNVEVDFPGKSTVVLTIRPSVF KPLEGAGSPVVSNVDAPSVQSRSQNKDYV Description (1)  TRIMETHYLAMINE DEHYDROGENASE (E.C.1.5.99.7), ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT, ELECTRON TRANSFER FLAVOPROTEIN ALPHA-SUBUNIT Functional site 1) chain A residue 27 type sequence V description BINDING SITE FOR RESIDUE FMN A 1730 source : AC1 2) chain A residue 28 type sequence P description BINDING SITE FOR RESIDUE FMN A 1730 source : AC1 3) chain A residue 29 type sequence H description BINDING SITE FOR RESIDUE FMN A 1730 source : AC1 4) chain A residue 30 type sequence C description BINDING SITE FOR RESIDUE FMN A 1730 source : AC1 5) chain A residue 60 type sequence Y description BINDING SITE FOR RESIDUE FMN A 1730 source : AC1 6) chain A residue 103 type sequence E description BINDING SITE FOR RESIDUE FMN A 1730 source : AC1 7) chain A residue 169 type sequence Y description BINDING SITE FOR RESIDUE FMN A 1730 source : AC1 8) chain A residue 172 type sequence H description BINDING SITE FOR RESIDUE FMN A 1730 source : AC1 9) chain A residue 222 type sequence R description BINDING SITE FOR RESIDUE FMN A 1730 source : AC1 10) chain A residue 264 type sequence W description BINDING SITE FOR RESIDUE FMN A 1730 source : AC1 11) chain A residue 267 type sequence D description BINDING SITE FOR RESIDUE FMN A 1730 source : AC1 12) chain A residue 268 type sequence A description BINDING SITE FOR RESIDUE FMN A 1730 source : AC1 13) chain A residue 297 type sequence V description BINDING SITE FOR RESIDUE FMN A 1730 source : AC1 14) chain A residue 299 type sequence R description BINDING SITE FOR RESIDUE FMN A 1730 source : AC1 15) chain A residue 320 type sequence C description BINDING SITE FOR RESIDUE FMN A 1730 source : AC1 16) chain A residue 321 type sequence A description BINDING SITE FOR RESIDUE FMN A 1730 source : AC1 17) chain A residue 322 type sequence R description BINDING SITE FOR RESIDUE FMN A 1730 source : AC1 18) chain A residue 323 type sequence P description BINDING SITE FOR RESIDUE FMN A 1730 source : AC1 19) chain A residue 352 type sequence I description BINDING SITE FOR RESIDUE FMN A 1730 source : AC1 20) chain A residue 395 type sequence V description BINDING SITE FOR RESIDUE ADP A 1731 source : AC2 21) chain A residue 396 type sequence G description BINDING SITE FOR RESIDUE ADP A 1731 source : AC2 22) chain A residue 398 type sequence G description BINDING SITE FOR RESIDUE ADP A 1731 source : AC2 23) chain A residue 399 type sequence P description BINDING SITE FOR RESIDUE ADP A 1731 source : AC2 24) chain A residue 400 type sequence S description BINDING SITE FOR RESIDUE ADP A 1731 source : AC2 25) chain A residue 419 type sequence D description BINDING SITE FOR RESIDUE ADP A 1731 source : AC2 26) chain A residue 420 type sequence T description BINDING SITE FOR RESIDUE ADP A 1731 source : AC2 27) chain A residue 426 type sequence G description BINDING SITE FOR RESIDUE ADP A 1731 source : AC2 28) chain A residue 427 type sequence H description BINDING SITE FOR RESIDUE ADP A 1731 source : AC2 29) chain A residue 469 type sequence P description BINDING SITE FOR RESIDUE ADP A 1731 source : AC2 30) chain A residue 470 type sequence M description BINDING SITE FOR RESIDUE ADP A 1731 source : AC2 31) chain A residue 486 type sequence A description BINDING SITE FOR RESIDUE ADP A 1731 source : AC2 32) chain A residue 487 type sequence T description BINDING SITE FOR RESIDUE ADP A 1731 source : AC2 33) chain A residue 488 type sequence G description BINDING SITE FOR RESIDUE ADP A 1731 source : AC2 34) chain A residue 673 type sequence G description BINDING SITE FOR RESIDUE ADP A 1731 source : AC2 35) chain A residue 674 type sequence D description BINDING SITE FOR RESIDUE ADP A 1731 source : AC2 36) chain A residue 322 type sequence R description BINDING SITE FOR RESIDUE SF4 A 1732 source : AC3 37) chain A residue 325 type sequence I description BINDING SITE FOR RESIDUE SF4 A 1732 source : AC3 38) chain A residue 345 type sequence C description BINDING SITE FOR RESIDUE SF4 A 1732 source : AC3 39) chain A residue 346 type sequence I description BINDING SITE FOR RESIDUE SF4 A 1732 source : AC3 40) chain A residue 347 type sequence G description BINDING SITE FOR RESIDUE SF4 A 1732 source : AC3 41) chain A residue 348 type sequence C description BINDING SITE FOR RESIDUE SF4 A 1732 source : AC3 42) chain A residue 349 type sequence N description BINDING SITE FOR RESIDUE SF4 A 1732 source : AC3 43) chain A residue 350 type sequence V description BINDING SITE FOR RESIDUE SF4 A 1732 source : AC3 44) chain A residue 351 type sequence C description BINDING SITE FOR RESIDUE SF4 A 1732 source : AC3 45) chain A residue 364 type sequence C description BINDING SITE FOR RESIDUE SF4 A 1732 source : AC3 46) chain A residue 365 type sequence T description BINDING SITE FOR RESIDUE SF4 A 1732 source : AC3 47) chain B residue 27 type sequence V description BINDING SITE FOR RESIDUE FMN B 1730 source : AC4 48) chain B residue 28 type sequence P description BINDING SITE FOR RESIDUE FMN B 1730 source : AC4 49) chain B residue 29 type sequence H description BINDING SITE FOR RESIDUE FMN B 1730 source : AC4 50) chain B residue 30 type sequence C description BINDING SITE FOR RESIDUE FMN B 1730 source : AC4 51) chain B residue 59 type sequence E description BINDING SITE FOR RESIDUE FMN B 1730 source : AC4 52) chain B residue 60 type sequence Y description BINDING SITE FOR RESIDUE FMN B 1730 source : AC4 53) chain B residue 103 type sequence E description BINDING SITE FOR RESIDUE FMN B 1730 source : AC4 54) chain B residue 169 type sequence Y description BINDING SITE FOR RESIDUE FMN B 1730 source : AC4 55) chain B residue 172 type sequence H description BINDING SITE FOR RESIDUE FMN B 1730 source : AC4 56) chain B residue 222 type sequence R description BINDING SITE FOR RESIDUE FMN B 1730 source : AC4 57) chain B residue 264 type sequence W description BINDING SITE FOR RESIDUE FMN B 1730 source : AC4 58) chain B residue 267 type sequence D description BINDING SITE FOR RESIDUE FMN B 1730 source : AC4 59) chain B residue 297 type sequence V description BINDING SITE FOR RESIDUE FMN B 1730 source : AC4 60) chain B residue 299 type sequence R description BINDING SITE FOR RESIDUE FMN B 1730 source : AC4 61) chain B residue 320 type sequence C description BINDING SITE FOR RESIDUE FMN B 1730 source : AC4 62) chain B residue 321 type sequence A description BINDING SITE FOR RESIDUE FMN B 1730 source : AC4 63) chain B residue 322 type sequence R description BINDING SITE FOR RESIDUE FMN B 1730 source : AC4 64) chain B residue 323 type sequence P description BINDING SITE FOR RESIDUE FMN B 1730 source : AC4 65) chain B residue 351 type sequence C description BINDING SITE FOR RESIDUE FMN B 1730 source : AC4 66) chain B residue 352 type sequence I description BINDING SITE FOR RESIDUE FMN B 1730 source : AC4 67) chain B residue 395 type sequence V description BINDING SITE FOR RESIDUE ADP B 1731 source : AC5 68) chain B residue 396 type sequence G description BINDING SITE FOR RESIDUE ADP B 1731 source : AC5 69) chain B residue 398 type sequence G description BINDING SITE FOR RESIDUE ADP B 1731 source : AC5 70) chain B residue 399 type sequence P description BINDING SITE FOR RESIDUE ADP B 1731 source : AC5 71) chain B residue 400 type sequence S description BINDING SITE FOR RESIDUE ADP B 1731 source : AC5 72) chain B residue 419 type sequence D description BINDING SITE FOR RESIDUE ADP B 1731 source : AC5 73) chain B residue 420 type sequence T description BINDING SITE FOR RESIDUE ADP B 1731 source : AC5 74) chain B residue 426 type sequence G description BINDING SITE FOR RESIDUE ADP B 1731 source : AC5 75) chain B residue 427 type sequence H description BINDING SITE FOR RESIDUE ADP B 1731 source : AC5 76) chain B residue 470 type sequence M description BINDING SITE FOR RESIDUE ADP B 1731 source : AC5 77) chain B residue 486 type sequence A description BINDING SITE FOR RESIDUE ADP B 1731 source : AC5 78) chain B residue 487 type sequence T description BINDING SITE FOR RESIDUE ADP B 1731 source : AC5 79) chain B residue 488 type sequence G description BINDING SITE FOR RESIDUE ADP B 1731 source : AC5 80) chain B residue 673 type sequence G description BINDING SITE FOR RESIDUE ADP B 1731 source : AC5 81) chain B residue 674 type sequence D description BINDING SITE FOR RESIDUE ADP B 1731 source : AC5 82) chain B residue 322 type sequence R description BINDING SITE FOR RESIDUE SF4 B 1732 source : AC6 83) chain B residue 325 type sequence I description BINDING SITE FOR RESIDUE SF4 B 1732 source : AC6 84) chain B residue 345 type sequence C description BINDING SITE FOR RESIDUE SF4 B 1732 source : AC6 85) chain B residue 346 type sequence I description BINDING SITE FOR RESIDUE SF4 B 1732 source : AC6 86) chain B residue 347 type sequence G description BINDING SITE FOR RESIDUE SF4 B 1732 source : AC6 87) chain B residue 348 type sequence C description BINDING SITE FOR RESIDUE SF4 B 1732 source : AC6 88) chain B residue 349 type sequence N description BINDING SITE FOR RESIDUE SF4 B 1732 source : AC6 89) chain B residue 350 type sequence V description BINDING SITE FOR RESIDUE SF4 B 1732 source : AC6 90) chain B residue 351 type sequence C description BINDING SITE FOR RESIDUE SF4 B 1732 source : AC6 91) chain B residue 364 type sequence C description BINDING SITE FOR RESIDUE SF4 B 1732 source : AC6 92) chain B residue 365 type sequence T description BINDING SITE FOR RESIDUE SF4 B 1732 source : AC6 93) chain C residue 6 type sequence A description BINDING SITE FOR RESIDUE AMP C 1236 source : AC7 94) chain C residue 7 type sequence V description BINDING SITE FOR RESIDUE AMP C 1236 source : AC7 95) chain C residue 36 type sequence N description BINDING SITE FOR RESIDUE AMP C 1236 source : AC7 96) chain C residue 39 type sequence D description BINDING SITE FOR RESIDUE AMP C 1236 source : AC7 97) chain C residue 62 type sequence V description BINDING SITE FOR RESIDUE AMP C 1236 source : AC7 98) chain C residue 64 type sequence V description BINDING SITE FOR RESIDUE AMP C 1236 source : AC7 99) chain C residue 100 type sequence V description BINDING SITE FOR RESIDUE AMP C 1236 source : AC7 100) chain C residue 118 type sequence A description BINDING SITE FOR RESIDUE AMP C 1236 source : AC7 101) chain C residue 119 type sequence G description BINDING SITE FOR RESIDUE AMP C 1236 source : AC7 102) chain C residue 121 type sequence Q description BINDING SITE FOR RESIDUE AMP C 1236 source : AC7 103) chain C residue 122 type sequence S description BINDING SITE FOR RESIDUE AMP C 1236 source : AC7 104) chain C residue 127 type sequence Y description BINDING SITE FOR RESIDUE AMP C 1236 source : AC7 105) chain C residue 128 type sequence A description BINDING SITE FOR RESIDUE AMP C 1236 source : AC7 106) chain C residue 129 type sequence S description BINDING SITE FOR RESIDUE AMP C 1236 source : AC7 107) chain C residue 130 type sequence T description BINDING SITE FOR RESIDUE AMP C 1236 source : AC7 108) chain E residue 6 type sequence A description BINDING SITE FOR RESIDUE AMP E 1237 source : AC8 109) chain E residue 7 type sequence V description BINDING SITE FOR RESIDUE AMP E 1237 source : AC8 110) chain E residue 8 type sequence K description BINDING SITE FOR RESIDUE AMP E 1237 source : AC8 111) chain E residue 36 type sequence N description BINDING SITE FOR RESIDUE AMP E 1237 source : AC8 112) chain E residue 39 type sequence D description BINDING SITE FOR RESIDUE AMP E 1237 source : AC8 113) chain E residue 64 type sequence V description BINDING SITE FOR RESIDUE AMP E 1237 source : AC8 114) chain E residue 100 type sequence V description BINDING SITE FOR RESIDUE AMP E 1237 source : AC8 115) chain E residue 118 type sequence A description BINDING SITE FOR RESIDUE AMP E 1237 source : AC8 116) chain E residue 119 type sequence G description BINDING SITE FOR RESIDUE AMP E 1237 source : AC8 117) chain E residue 121 type sequence Q description BINDING SITE FOR RESIDUE AMP E 1237 source : AC8 118) chain E residue 122 type sequence S description BINDING SITE FOR RESIDUE AMP E 1237 source : AC8 119) chain E residue 126 type sequence A description BINDING SITE FOR RESIDUE AMP E 1237 source : AC8 120) chain E residue 127 type sequence Y description BINDING SITE FOR RESIDUE AMP E 1237 source : AC8 121) chain E residue 128 type sequence A description BINDING SITE FOR RESIDUE AMP E 1237 source : AC8 122) chain E residue 129 type sequence S description BINDING SITE FOR RESIDUE AMP E 1237 source : AC8 123) chain E residue 130 type sequence T description BINDING SITE FOR RESIDUE AMP E 1237 source : AC8 124) chain A residue 175 type ACT_SITE sequence L description Proton donor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 125) chain B residue 175 type ACT_SITE sequence L description Proton donor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 126) chain B residue 223 type BINDING sequence F description source Swiss-Prot : SWS_FT_FI2 127) chain B residue 268 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2 128) chain B residue 323 type BINDING sequence P description source Swiss-Prot : SWS_FT_FI2 129) chain B residue 346 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI2 130) chain B residue 349 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2 131) chain B residue 352 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI2 132) chain B residue 365 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI2 133) chain A residue 346 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI2 134) chain A residue 349 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2 135) chain A residue 352 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI2 136) chain A residue 365 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI2 137) chain B residue 104 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI2 138) chain A residue 104 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI2 139) chain A residue 223 type BINDING sequence F description source Swiss-Prot : SWS_FT_FI2 140) chain A residue 268 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2 141) chain A residue 323 type BINDING sequence P description source Swiss-Prot : SWS_FT_FI2 142) chain A residue 31 type catalytic sequence I description 114 source MCSA : MCSA1 143) chain A residue 170 type catalytic sequence G description 114 source MCSA : MCSA1 144) chain A residue 173 type catalytic sequence S description 114 source MCSA : MCSA1 145) chain A residue 268 type catalytic sequence A description 114 source MCSA : MCSA1 146) chain B residue 31 type catalytic sequence I description 114 source MCSA : MCSA2 147) chain B residue 170 type catalytic sequence G description 114 source MCSA : MCSA2 148) chain B residue 173 type catalytic sequence S description 114 source MCSA : MCSA2 149) chain B residue 268 type catalytic sequence A description 114 source MCSA : MCSA2 150) chain C residue 160-181 type prosite sequence IRRELEGGMLQEVEINCPAVLT description ETF_BETA Electron transfer flavoprotein beta-subunit signature. IrRelEGGmlQeVeincPaVLT source prosite : PS01065 151) chain A residue 170 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 152) chain A residue 392 type BINDING sequence V description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 153) chain B residue 170 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 154) chain B residue 392 type BINDING sequence V description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 155) chain A residue 31 type MOD_RES sequence I description S-6-FMN cysteine source Swiss-Prot : SWS_FT_FI4 156) chain B residue 31 type MOD_RES sequence I description S-6-FMN cysteine source Swiss-Prot : SWS_FT_FI4

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