|
|
eF-site ID
|
1o5m-A |
|
PDB Code
|
1o5m |
|
Chain
|
A |
|
click to enlarge
|
|
|
Title
|
Structure of FPT bound to the inhibitor SCH66336 |
|
Classification
|
transferase/transferase inhibitor |
|
Compound
|
Protein farnesyltransferase alpha subunit |
|
Source
|
Rattus norvegicus (Rat) (PFTB_RAT) |
|
|
Sequence
|
A: |
GFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYS
EKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTV
WHFRRVLLRSLQKDLQEEMNYITAIIEEQPKNYQVWHHRR
VLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEF
RLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDR
AVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYP
NLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDI
LNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHS
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
164 |
| type |
|
| sequence |
K
|
| description |
BINDING SITE FOR RESIDUE FPP B 2001
|
| source |
: AC2
|
|
|
2)
|
chain |
A |
| residue |
166 |
| type |
|
| sequence |
Y
|
| description |
BINDING SITE FOR RESIDUE FPP B 2001
|
| source |
: AC2
|
|
|
3)
|
chain |
A |
| residue |
164 |
| type |
|
| sequence |
K
|
| description |
BINDING SITE FOR RESIDUE 336 B 3001
|
| source |
: AC3
|
|
|
4)
|
chain |
A |
| residue |
166 |
| type |
|
| sequence |
Y
|
| description |
BINDING SITE FOR RESIDUE 336 B 3001
|
| source |
: AC3
|
|
|
5)
|
chain |
A |
| residue |
201 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE 336 B 3001
|
| source |
: AC3
|
|
|
|