eF-site ID 1o23-ABCD PDB Code 1o23 Chain A, B, C, D click to enlarge Title CRYSTAL STRUCTURE OF LACTOSE SYNTHASE IN THE PRESENCE OF UDP-GLUCOSE Classification TRANSFERASE ACTIVATOR/TRANSFERASE Compound ALPHA-LACTALBUMIN Source Mus musculus (Mouse) (B4GT1_BOVIN) Sequence A:  TELTKCKVSHAIKDIDGYQGISLLEWACVLFHTSGYDTQA VVNDNGSTEYGLFQISDRFWCKSSEFPESENICGISCDKL LDDELDDDIACAKKILAIKGIDYWKAYKPMCSEKLEQWRC EKP B:  LTACPEESPLLVGPMLIEFNIPVDLKLVEQQNPKVKLGGR YTPMDCISPHKVAIIIPFRNRQEHLKYWLYYLHPILQRQQ LDYGIYVINQAGESMFNRAKLLNVGFKEALKDYDYNCFVF SDVDLIPMNDHNTYRCFSQPRHISVAMDKFGFSLPYVQYF GGVSALSKQQFLSINGFPNNYWGWGGEDDDIYNRLAFRGM SVSRPNAVIGKCRMIRHSRDKKNEPNPQRFDRIAHTKETM LSDGLNSLTYMVLEVQRYPLYTKITVDIGTPS C:  TELTKCKVSHAIKDIDGYQGISLLEWACVLFHTSGYDTQA VVNDNGSTEYGLFQISDRFWCKSSEFPESENICGISCDKL LDDELDDDIACAKKILAIKGIDYWKAYKPMCSEKLEQWRC EKP D:  LTACPEESPLLVGPMLIEFNIPVDLKLVEQQNPKVKLGGR YTPMDCISPHKVAIIIPFRNRQEHLKYWLYYLHPILQRQQ LDYGIYVINQAGESMFNRAKLLNVGFKEALKDYDYNCFVF SDVDLIPMNDHNTYRCFSQPRHISVAMDKFGFSLPYVQYF GGVSALSKQQFLSINGFPNNYWGWGGEDDDIYNRLAFRGM SVSRPNAVIGKCRMIRHSRDKKNEPNPQRFDRIAHTKETM LSDGLNSLTYMVLEVQRYPLYTKITVDIGTPS Description Functional site 1) chain A residue 79 type sequence K description BINDING SITE FOR RESIDUE CA A 805 source : AC1 2) chain A residue 82 type sequence D description BINDING SITE FOR RESIDUE CA A 805 source : AC1 3) chain A residue 84 type sequence E description BINDING SITE FOR RESIDUE CA A 805 source : AC1 4) chain A residue 87 type sequence D description BINDING SITE FOR RESIDUE CA A 805 source : AC1 5) chain A residue 88 type sequence D description BINDING SITE FOR RESIDUE CA A 805 source : AC1 6) chain C residue 481 type sequence K description BINDING SITE FOR RESIDUE CA C 806 source : AC2 7) chain C residue 484 type sequence D description BINDING SITE FOR RESIDUE CA C 806 source : AC2 8) chain C residue 486 type sequence E description BINDING SITE FOR RESIDUE CA C 806 source : AC2 9) chain C residue 489 type sequence D description BINDING SITE FOR RESIDUE CA C 806 source : AC2 10) chain C residue 490 type sequence D description BINDING SITE FOR RESIDUE CA C 806 source : AC2 11) chain B residue 254 type sequence D description BINDING SITE FOR RESIDUE MN B 807 source : AC3 12) chain B residue 344 type sequence M description BINDING SITE FOR RESIDUE MN B 807 source : AC3 13) chain B residue 347 type sequence H description BINDING SITE FOR RESIDUE MN B 807 source : AC3 14) chain D residue 656 type sequence D description BINDING SITE FOR RESIDUE MN D 808 source : AC4 15) chain D residue 746 type sequence M description BINDING SITE FOR RESIDUE MN D 808 source : AC4 16) chain D residue 749 type sequence H description BINDING SITE FOR RESIDUE MN D 808 source : AC4 17) chain B residue 187 type sequence P description BINDING SITE FOR RESIDUE UPG B 809 source : AC5 18) chain B residue 188 type sequence F description BINDING SITE FOR RESIDUE UPG B 809 source : AC5 19) chain B residue 189 type sequence R description BINDING SITE FOR RESIDUE UPG B 809 source : AC5 20) chain B residue 191 type sequence R description BINDING SITE FOR RESIDUE UPG B 809 source : AC5 21) chain B residue 226 type sequence F description BINDING SITE FOR RESIDUE UPG B 809 source : AC5 22) chain B residue 228 type sequence R description BINDING SITE FOR RESIDUE UPG B 809 source : AC5 23) chain B residue 252 type sequence D description BINDING SITE FOR RESIDUE UPG B 809 source : AC5 24) chain B residue 253 type sequence V description BINDING SITE FOR RESIDUE UPG B 809 source : AC5 25) chain B residue 254 type sequence D description BINDING SITE FOR RESIDUE UPG B 809 source : AC5 26) chain B residue 289 type sequence Y description BINDING SITE FOR RESIDUE UPG B 809 source : AC5 27) chain B residue 292 type sequence G description BINDING SITE FOR RESIDUE UPG B 809 source : AC5 28) chain B residue 314 type sequence W description BINDING SITE FOR RESIDUE UPG B 809 source : AC5 29) chain B residue 317 type sequence E description BINDING SITE FOR RESIDUE UPG B 809 source : AC5 30) chain B residue 318 type sequence D description BINDING SITE FOR RESIDUE UPG B 809 source : AC5 31) chain B residue 344 type sequence M description BINDING SITE FOR RESIDUE UPG B 809 source : AC5 32) chain B residue 347 type sequence H description BINDING SITE FOR RESIDUE UPG B 809 source : AC5 33) chain B residue 350 type sequence D description BINDING SITE FOR RESIDUE UPG B 809 source : AC5 34) chain D residue 589 type sequence P description BINDING SITE FOR RESIDUE UPG D 810 source : AC6 35) chain D residue 590 type sequence F description BINDING SITE FOR RESIDUE UPG D 810 source : AC6 36) chain D residue 591 type sequence R description BINDING SITE FOR RESIDUE UPG D 810 source : AC6 37) chain D residue 593 type sequence R description BINDING SITE FOR RESIDUE UPG D 810 source : AC6 38) chain D residue 628 type sequence F description BINDING SITE FOR RESIDUE UPG D 810 source : AC6 39) chain D residue 630 type sequence R description BINDING SITE FOR RESIDUE UPG D 810 source : AC6 40) chain D residue 654 type sequence D description BINDING SITE FOR RESIDUE UPG D 810 source : AC6 41) chain D residue 655 type sequence V description BINDING SITE FOR RESIDUE UPG D 810 source : AC6 42) chain D residue 656 type sequence D description BINDING SITE FOR RESIDUE UPG D 810 source : AC6 43) chain D residue 691 type sequence Y description BINDING SITE FOR RESIDUE UPG D 810 source : AC6 44) chain D residue 694 type sequence G description BINDING SITE FOR RESIDUE UPG D 810 source : AC6 45) chain D residue 716 type sequence W description BINDING SITE FOR RESIDUE UPG D 810 source : AC6 46) chain D residue 717 type sequence G description BINDING SITE FOR RESIDUE UPG D 810 source : AC6 47) chain D residue 719 type sequence E description BINDING SITE FOR RESIDUE UPG D 810 source : AC6 48) chain D residue 720 type sequence D description BINDING SITE FOR RESIDUE UPG D 810 source : AC6 49) chain D residue 746 type sequence M description BINDING SITE FOR RESIDUE UPG D 810 source : AC6 50) chain D residue 749 type sequence H description BINDING SITE FOR RESIDUE UPG D 810 source : AC6 51) chain D residue 752 type sequence D description BINDING SITE FOR RESIDUE UPG D 810 source : AC6 52) chain B residue 155 type sequence L description BINDING SITE FOR RESIDUE UDP B 811 source : AC7 53) chain B residue 156 type sequence K description BINDING SITE FOR RESIDUE UDP B 811 source : AC7 54) chain B residue 159 type sequence E description BINDING SITE FOR RESIDUE UDP B 811 source : AC7 55) chain B residue 192 type sequence Q description BINDING SITE FOR RESIDUE UDP B 811 source : AC7 56) chain B residue 386 type sequence Q description BINDING SITE FOR RESIDUE UDP B 811 source : AC7 57) chain B residue 388 type sequence Y description BINDING SITE FOR RESIDUE UDP B 811 source : AC7 58) chain B residue 389 type sequence P description BINDING SITE FOR RESIDUE UDP B 811 source : AC7 59) chain B residue 390 type sequence L description BINDING SITE FOR RESIDUE UDP B 811 source : AC7 60) chain B residue 391 type sequence Y description BINDING SITE FOR RESIDUE UDP B 811 source : AC7 61) chain B residue 393 type sequence K description BINDING SITE FOR RESIDUE UDP B 811 source : AC7 62) chain D residue 557 type sequence L description BINDING SITE FOR RESIDUE UDP D 812 source : AC8 63) chain D residue 558 type sequence K description BINDING SITE FOR RESIDUE UDP D 812 source : AC8 64) chain D residue 790 type sequence Y description BINDING SITE FOR RESIDUE UDP D 812 source : AC8 65) chain D residue 791 type sequence P description BINDING SITE FOR RESIDUE UDP D 812 source : AC8 66) chain D residue 792 type sequence L description BINDING SITE FOR RESIDUE UDP D 812 source : AC8 67) chain D residue 793 type sequence Y description BINDING SITE FOR RESIDUE UDP D 812 source : AC8 68) chain D residue 795 type sequence K description BINDING SITE FOR RESIDUE UDP D 812 source : AC8 69) chain A residue 2 type sequence E description BINDING SITE FOR RESIDUE PG4 A 813 source : AC9 70) chain A residue 31 type sequence F description BINDING SITE FOR RESIDUE PG4 A 813 source : AC9 71) chain A residue 32 type sequence H description BINDING SITE FOR RESIDUE PG4 A 813 source : AC9 72) chain A residue 33 type sequence T description BINDING SITE FOR RESIDUE PG4 A 813 source : AC9 73) chain A residue 34 type sequence S description BINDING SITE FOR RESIDUE PG4 A 813 source : AC9 74) chain A residue 35 type sequence G description BINDING SITE FOR RESIDUE PG4 A 813 source : AC9 75) chain A residue 40 type sequence A description BINDING SITE FOR RESIDUE PG4 A 813 source : AC9 76) chain B residue 279 type sequence K description BINDING SITE FOR RESIDUE PG4 A 813 source : AC9 77) chain B residue 314 type sequence W description BINDING SITE FOR RESIDUE PG4 A 813 source : AC9 78) chain B residue 349 type sequence R description BINDING SITE FOR RESIDUE PG4 A 813 source : AC9 79) chain C residue 433 type sequence F description BINDING SITE FOR RESIDUE PG4 C 814 source : BC1 80) chain C residue 434 type sequence H description BINDING SITE FOR RESIDUE PG4 C 814 source : BC1 81) chain C residue 435 type sequence T description BINDING SITE FOR RESIDUE PG4 C 814 source : BC1 82) chain C residue 436 type sequence S description BINDING SITE FOR RESIDUE PG4 C 814 source : BC1 83) chain C residue 437 type sequence G description BINDING SITE FOR RESIDUE PG4 C 814 source : BC1 84) chain D residue 682 type sequence F description BINDING SITE FOR RESIDUE PG4 C 814 source : BC1 85) chain D residue 716 type sequence W description BINDING SITE FOR RESIDUE PG4 C 814 source : BC1 86) chain D residue 751 type sequence R description BINDING SITE FOR RESIDUE PG4 C 814 source : BC1 87) chain A residue 114 type sequence K description BINDING SITE FOR RESIDUE MES A 815 source : BC2 88) chain A residue 115 type sequence L description BINDING SITE FOR RESIDUE MES A 815 source : BC2 89) chain A residue 116 type sequence E description BINDING SITE FOR RESIDUE MES A 815 source : BC2 90) chain B residue 239 type catalytic sequence A description 570 source MCSA : MCSA1 91) chain B residue 241 type catalytic sequence K description 570 source MCSA : MCSA1 92) chain B residue 301 type catalytic sequence F description 570 source MCSA : MCSA1 93) chain B residue 304 type catalytic sequence I description 570 source MCSA : MCSA1 94) chain B residue 305 type catalytic sequence N description 570 source MCSA : MCSA1 95) chain B residue 331 type catalytic sequence S description 570 source MCSA : MCSA1 96) chain B residue 334 type catalytic sequence R description 570 source MCSA : MCSA1 97) chain B residue 336 type catalytic sequence N description 570 source MCSA : MCSA1 98) chain D residue 641 type catalytic sequence A description 570 source MCSA : MCSA2 99) chain D residue 643 type catalytic sequence K description 570 source MCSA : MCSA2 100) chain D residue 703 type catalytic sequence F description 570 source MCSA : MCSA2 101) chain D residue 706 type catalytic sequence I description 570 source MCSA : MCSA2 102) chain D residue 707 type catalytic sequence N description 570 source MCSA : MCSA2 103) chain D residue 733 type catalytic sequence S description 570 source MCSA : MCSA2 104) chain D residue 736 type catalytic sequence R description 570 source MCSA : MCSA2 105) chain D residue 738 type catalytic sequence N description 570 source MCSA : MCSA2 106) chain B residue 174 type BINDING sequence M description source Swiss-Prot : SWS_FT_FI1 107) chain D residue 615 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI1 108) chain D residue 642 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI1 109) chain D residue 643 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI1 110) chain D residue 703 type BINDING sequence F description source Swiss-Prot : SWS_FT_FI1 111) chain D residue 705 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI1 112) chain D residue 736 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 113) chain D residue 748 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 114) chain B residue 213 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI1 115) chain B residue 240 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI1 116) chain B residue 241 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI1 117) chain B residue 301 type BINDING sequence F description source Swiss-Prot : SWS_FT_FI1 118) chain B residue 303 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI1 119) chain B residue 334 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 120) chain B residue 346 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 121) chain D residue 576 type BINDING sequence M description source Swiss-Prot : SWS_FT_FI1 122) chain A residue 45 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 123) chain C residue 447 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 124) chain A residue 73-91 type prosite sequence CGISCDKLLDDELDDDIAC description GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. CgisCdkLlddELdddiaC source prosite : PS00128

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