eF-site ID 1nyj-ABCD PDB Code 1nyj Chain A, B, C, D click to enlarge Title The closed state structure of M2 protein H+ channel by solid state NMR spectroscopy Classification VIRAL PROTEIN Compound Matrix protein M2 Source Influenza A virus (strain A/USSR/90/1977 H1N1) (VMT2_IAUSS) Sequence A:  SSDPLVVAASIIGILHLILWILDRL B:  SSDPLVVAASIIGILHLILWILDRL C:  SSDPLVVAASIIGILHLILWILDRL D:  SSDPLVVAASIIGILHLILWILDRL Description Functional site 1) chain A residue 2-22 type TRANSMEM sequence SDPLVVAASIIGILHLILWIL description Helical; Signal-anchor for type III membrane protein => ECO:0000255|HAMAP-Rule:MF_04069 source Swiss-Prot : SWS_FT_FI1 2) chain B residue 2-22 type TRANSMEM sequence SDPLVVAASIIGILHLILWIL description Helical; Signal-anchor for type III membrane protein => ECO:0000255|HAMAP-Rule:MF_04069 source Swiss-Prot : SWS_FT_FI1 3) chain C residue 2-22 type TRANSMEM sequence SDPLVVAASIIGILHLILWIL description Helical; Signal-anchor for type III membrane protein => ECO:0000255|HAMAP-Rule:MF_04069 source Swiss-Prot : SWS_FT_FI1 4) chain D residue 2-22 type TRANSMEM sequence SDPLVVAASIIGILHLILWIL description Helical; Signal-anchor for type III membrane protein => ECO:0000255|HAMAP-Rule:MF_04069 source Swiss-Prot : SWS_FT_FI1 5) chain B residue 16 type SITE sequence H description Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter => ECO:0000255|HAMAP-Rule:MF_04069 source Swiss-Prot : SWS_FT_FI2 6) chain C residue 16 type SITE sequence H description Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter => ECO:0000255|HAMAP-Rule:MF_04069 source Swiss-Prot : SWS_FT_FI2 7) chain D residue 16 type SITE sequence H description Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter => ECO:0000255|HAMAP-Rule:MF_04069 source Swiss-Prot : SWS_FT_FI2 8) chain A residue 16 type SITE sequence H description Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter => ECO:0000255|HAMAP-Rule:MF_04069 source Swiss-Prot : SWS_FT_FI2 9) chain B residue 20 type SITE sequence W description Seems to be involved in pH gating => ECO:0000255|HAMAP-Rule:MF_04069 source Swiss-Prot : SWS_FT_FI3 10) chain C residue 20 type SITE sequence W description Seems to be involved in pH gating => ECO:0000255|HAMAP-Rule:MF_04069 source Swiss-Prot : SWS_FT_FI3 11) chain D residue 20 type SITE sequence W description Seems to be involved in pH gating => ECO:0000255|HAMAP-Rule:MF_04069 source Swiss-Prot : SWS_FT_FI3 12) chain A residue 20 type SITE sequence W description Seems to be involved in pH gating => ECO:0000255|HAMAP-Rule:MF_04069 source Swiss-Prot : SWS_FT_FI3

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