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eF-site ID
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1nxc-A |
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PDB Code
|
1nxc |
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Chain
|
A |
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click to enlarge
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Title
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Structure of mouse Golgi alpha-1,2-mannosidase IA reveals the molecular basis for substrate specificity among Class I enzymes (family 47 glycosidases) |
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Classification
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HYDROLASE |
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Compound
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Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA |
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Source
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(M1A1_MOUSE) |
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Sequence
|
A: |
FLPPVGVENREPADATIREKRAKIKEMMTHAWNNYKRYAW
GLNELKPISKEGHSSSLFGNIKGATIVDALDTLFIMGMKT
EFQEAKSWIKKYLDFNVNAEVSVFEVNIRFVGGLLSAYYL
SGEEIFRKKAVELGVKLLPAFHTPSGIPWALLNMKSGIGR
NWPWASGGSSILAEFGTLHLEFMHLSHLSGDPVFAEKVMK
IRTVLNKLDKPEGLYPNYLNPSSGQWGQHHVSVGGLGDSF
YEYLLKAWLMSDKTDLEAKKMYFDAVQAIETHLIRKSSGG
LTYIAEWKGGLLEHKMGHLTCFAGGMFALGADGAPEARAQ
HYLELGAEIARTCHESYNRTYVKLGPEAFRFDGGVEAIAT
RQNEKYYILRPEVIETYMYMWRLTHDPKYRTWAWEAVEAL
ESHCRVNGGYSGLRDVYIARESYDDVQQSFFLAETLKYLY
LIFSDDDLLPLEHWIFNTEAHPFPILR
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Description
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(1) |
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (E.C.3.2.1.113)
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Functional site
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|
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1)
|
chain |
A |
| residue |
635 |
| type |
BINDING |
| sequence |
T
|
| description |
BINDING => ECO:0000269|PubMed:15102839, ECO:0007744|PDB:1NXC
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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2)
|
chain |
A |
| residue |
524 |
| type |
ACT_SITE |
| sequence |
E
|
| description |
Proton donor => ECO:0000250|UniProtKB:P31723
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
A |
| residue |
515 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15102839, ECO:0007744|PDB:1NXC
|
| source |
Swiss-Prot : SWS_FT_FI3
|
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