eF-site ID 1nwc-AB PDB Code 1nwc Chain A, B click to enlarge Title Crystal Structure of Aspartate-Semialdehyde Dehydrogenase from Haemophilus influenzae Classification OXIDOREDUCTASE Compound Aspartate-semialdehyde dehydrogenase Source null (DHAS_HAEIN) Sequence A:  MKNVGFIGWRGMVGSVLMDRMSQENDFENLNPVFFTTSQL KSAFDIEELKKLDIIVTCQGGDYTNEVYPKLKATGWDGYW VDAASALRMKDDAIIVLDPVNQHVISEGLKKGIKTFVGGN CTVSLMLMAIGGLFEKDLVEWISVATYQAASGAGAKNMRE LLSQMGLLEQAVSSELKDPASSILDIERKVTAKMRADNFP TDNFGAALGGSLIPWIDKLLPETGQTKEEWKGYAETNKIL GLSDNPIPVDGLCVRIGALRCHSQAFTIKLKKDLPLEEIE QIIASHNEWVKVIPNDKEITLRELTPAKVTGTLSVPVGRL RKLAMGPEYLAAFTVGDQLLWGAAEPVRRILKQLVA B:  MKNVGFIGWRGMVGSVLMDRMSQENDFENLNPVFFTTSQL KSAFDIEELKKLDIIVTCQGGDYTNEVYPKLKATGWDGYW VDAASALRMKDDAIIVLDPVNQHVISEGLKKGIKTFVGGN CTVSLMLMAIGGLFEKDLVEWISVATYQAASGAGAKNMRE LLSQMGLLEQAVSSELKDPASSILDIERKVTAKMRADNFP TDNFGAALGGSLIPWIDKLLPETGQTKEEWKGYAETNKIL GLSDNPIPVDGLCVRIGALRCHSQAFTIKLKKDLPLEEIE QIIASHNEWVKVIPNDKEITLRELTPAKVTGTLSVPVGRL RKLAMGPEYLAAFTVGDQLLWGAAEPVRRILKQLVA Description Functional site 1) chain A residue 136 type ACT_SITE sequence C description Acyl-thioester intermediate => ECO:0000269|PubMed:14559965, ECO:0000269|PubMed:15272161 source Swiss-Prot : SWS_FT_FI1 2) chain B residue 136 type ACT_SITE sequence C description Acyl-thioester intermediate => ECO:0000269|PubMed:14559965, ECO:0000269|PubMed:15272161 source Swiss-Prot : SWS_FT_FI1 3) chain B residue 277 type ACT_SITE sequence H description Proton acceptor => ECO:0000269|PubMed:14559965 source Swiss-Prot : SWS_FT_FI2 4) chain A residue 277 type ACT_SITE sequence H description Proton acceptor => ECO:0000269|PubMed:14559965 source Swiss-Prot : SWS_FT_FI2 5) chain A residue 10 type BINDING sequence R description BINDING => ECO:0000269|PubMed:15272161 source Swiss-Prot : SWS_FT_FI3 6) chain A residue 37 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15272161 source Swiss-Prot : SWS_FT_FI3 7) chain B residue 353 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:15272161 source Swiss-Prot : SWS_FT_FI3 8) chain A residue 74 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:15272161 source Swiss-Prot : SWS_FT_FI3 9) chain A residue 166 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15272161 source Swiss-Prot : SWS_FT_FI3 10) chain A residue 353 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:15272161 source Swiss-Prot : SWS_FT_FI3 11) chain B residue 10 type BINDING sequence R description BINDING => ECO:0000269|PubMed:15272161 source Swiss-Prot : SWS_FT_FI3 12) chain B residue 37 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15272161 source Swiss-Prot : SWS_FT_FI3 13) chain B residue 74 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:15272161 source Swiss-Prot : SWS_FT_FI3 14) chain B residue 166 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15272161 source Swiss-Prot : SWS_FT_FI3 15) chain A residue 103 type BINDING sequence R description BINDING => ECO:0000269|PubMed:14559965 source Swiss-Prot : SWS_FT_FI4 16) chain A residue 246 type BINDING sequence K description BINDING => ECO:0000269|PubMed:14559965 source Swiss-Prot : SWS_FT_FI4 17) chain B residue 103 type BINDING sequence R description BINDING => ECO:0000269|PubMed:14559965 source Swiss-Prot : SWS_FT_FI4 18) chain B residue 246 type BINDING sequence K description BINDING => ECO:0000269|PubMed:14559965 source Swiss-Prot : SWS_FT_FI4 19) chain A residue 163 type BINDING sequence Q description BINDING => ECO:0000305|PubMed:15272161 source Swiss-Prot : SWS_FT_FI5 20) chain A residue 243 type BINDING sequence E description BINDING => ECO:0000305|PubMed:15272161 source Swiss-Prot : SWS_FT_FI5 21) chain A residue 270 type BINDING sequence R description BINDING => ECO:0000305|PubMed:15272161 source Swiss-Prot : SWS_FT_FI5 22) chain B residue 243 type BINDING sequence E description BINDING => ECO:0000305|PubMed:15272161 source Swiss-Prot : SWS_FT_FI5 23) chain B residue 270 type BINDING sequence R description BINDING => ECO:0000305|PubMed:15272161 source Swiss-Prot : SWS_FT_FI5 24) chain B residue 163 type BINDING sequence Q description BINDING => ECO:0000305|PubMed:15272161 source Swiss-Prot : SWS_FT_FI5 25) chain A residue 264-278 type prosite sequence VDGLCVRIGALRCHS description ASD Aspartate-semialdehyde dehydrogenase signature. VDglCvRIgalrCHS source prosite : PS01103

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