eF-site ID 1nvu-S PDB Code 1nvu Chain S click to enlarge Title Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS Classification SIGNALING PROTEIN Compound Transforming protein p21/H-RAS-1 Source Homo sapiens (Human) (SOS1_HUMAN) Sequence S:  QMRLPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLIE RLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIP EPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLN VCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVE SITKIIQRKKIAHNITFQSSPPTVEWHISRPGHIETFDLL TLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEIN SPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIE ILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQ KKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNI LKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQ PYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIE PRNPKPLPRFPKKYSYPLKSPGVRPSNPR Description Functional site 1) chain S residue 625 type sequence R description BINDING SITE FOR RESIDUE PO4 S 1047 source : AC3 2) chain S residue 695 type sequence H description BINDING SITE FOR RESIDUE PO4 S 1047 source : AC3 3) chain S residue 699 type sequence H description BINDING SITE FOR RESIDUE PO4 S 1047 source : AC3 4) chain S residue 700 type sequence H description BINDING SITE FOR RESIDUE PO4 S 1047 source : AC3 5) chain S residue 814 type sequence K description BINDING SITE FOR RESIDUE PO4 S 1048 source : AC4 6) chain S residue 815 type sequence E description BINDING SITE FOR RESIDUE PO4 S 1048 source : AC4 7) chain S residue 826 type sequence R description BINDING SITE FOR RESIDUE PO4 S 1048 source : AC4 8) chain S residue 660 type sequence R description BINDING SITE FOR RESIDUE PO4 S 1049 source : AC5 9) chain S residue 709 type sequence Y description BINDING SITE FOR RESIDUE PO4 S 1049 source : AC5 10) chain S residue 716 type sequence E description BINDING SITE FOR RESIDUE PO4 S 1049 source : AC5 11) chain S residue 951 type sequence H description BINDING SITE FOR RESIDUE PO4 S 1049 source : AC5 12) chain S residue 927-960 type prosite sequence VPFFGIYLTNILKTEEGNPEVLKRHGKELINFSK description RASGEF Ras Guanine-nucleotide exchange factors domain signature. VPFfGiyLtNIlkteegnpevlkrhgkel.................INFsK source prosite : PS00720

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