eF-site ID 1nvu-Q PDB Code 1nvu Chain Q click to enlarge Title Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS Classification SIGNALING PROTEIN Compound Transforming protein p21/H-RAS-1 Source Homo sapiens (Human) (SOS1_HUMAN) Sequence Q:  MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSY RKQVVIDGETCLLDILDTGGQEEYSAMRDQYMRTGEGFLC VFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLV REIRQH Description Functional site 1) chain Q residue 17 type sequence S description BINDING SITE FOR RESIDUE MG Q 1002 source : AC1 2) chain Q residue 35 type sequence T description BINDING SITE FOR RESIDUE MG Q 1002 source : AC1 3) chain Q residue 153 type sequence E description BINDING SITE FOR RESIDUE PO4 Q 1007 source : AC6 4) chain Q residue 154 type sequence D description BINDING SITE FOR RESIDUE PO4 Q 1007 source : AC6 5) chain Q residue 157 type sequence Y description BINDING SITE FOR RESIDUE PO4 Q 1007 source : AC6 6) chain Q residue 161 type sequence R description BINDING SITE FOR RESIDUE PO4 Q 1007 source : AC6 7) chain Q residue 12 type sequence G description BINDING SITE FOR RESIDUE GTP Q 1001 source : AC7 8) chain Q residue 13 type sequence G description BINDING SITE FOR RESIDUE GTP Q 1001 source : AC7 9) chain Q residue 14 type sequence V description BINDING SITE FOR RESIDUE GTP Q 1001 source : AC7 10) chain Q residue 15 type sequence G description BINDING SITE FOR RESIDUE GTP Q 1001 source : AC7 11) chain Q residue 16 type sequence K description BINDING SITE FOR RESIDUE GTP Q 1001 source : AC7 12) chain Q residue 17 type sequence S description BINDING SITE FOR RESIDUE GTP Q 1001 source : AC7 13) chain Q residue 18 type sequence A description BINDING SITE FOR RESIDUE GTP Q 1001 source : AC7 14) chain Q residue 28 type sequence F description BINDING SITE FOR RESIDUE GTP Q 1001 source : AC7 15) chain Q residue 29 type sequence V description BINDING SITE FOR RESIDUE GTP Q 1001 source : AC7 16) chain Q residue 30 type sequence D description BINDING SITE FOR RESIDUE GTP Q 1001 source : AC7 17) chain Q residue 32 type sequence Y description BINDING SITE FOR RESIDUE GTP Q 1001 source : AC7 18) chain Q residue 34 type sequence P description BINDING SITE FOR RESIDUE GTP Q 1001 source : AC7 19) chain Q residue 35 type sequence T description BINDING SITE FOR RESIDUE GTP Q 1001 source : AC7 20) chain Q residue 60 type sequence G description BINDING SITE FOR RESIDUE GTP Q 1001 source : AC7 21) chain Q residue 62 type sequence E description BINDING SITE FOR RESIDUE GTP Q 1001 source : AC7 22) chain Q residue 116 type sequence N description BINDING SITE FOR RESIDUE GTP Q 1001 source : AC7 23) chain Q residue 117 type sequence K description BINDING SITE FOR RESIDUE GTP Q 1001 source : AC7 24) chain Q residue 119 type sequence D description BINDING SITE FOR RESIDUE GTP Q 1001 source : AC7 25) chain Q residue 120 type sequence L description BINDING SITE FOR RESIDUE GTP Q 1001 source : AC7 26) chain Q residue 145 type sequence S description BINDING SITE FOR RESIDUE GTP Q 1001 source : AC7 27) chain Q residue 146 type sequence A description BINDING SITE FOR RESIDUE GTP Q 1001 source : AC7 28) chain Q residue 147 type sequence K description BINDING SITE FOR RESIDUE GTP Q 1001 source : AC7 29) chain Q residue 13 type BINDING sequence G description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 30) chain Q residue 29 type BINDING sequence V description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 31) chain Q residue 59 type BINDING sequence G description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 32) chain Q residue 116 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 33) chain Q residue 145 type BINDING sequence S description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 34) chain Q residue 1 type MOD_RES sequence M description N-acetylmethionine; in GTPase HRas; alternate => ECO:0000269|Ref.12 source Swiss-Prot : SWS_FT_FI2 35) chain Q residue 2 type MOD_RES sequence T description N-acetylthreonine; in GTPase HRas, N-terminally processed => ECO:0000269|Ref.12 source Swiss-Prot : SWS_FT_FI3 36) chain Q residue 118 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000269|PubMed:9020151 source Swiss-Prot : SWS_FT_FI4 37) chain Q residue 35 type CARBOHYD sequence T description (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:8626575, ECO:0000269|PubMed:8626586, ECO:0000269|PubMed:9632667 source Swiss-Prot : SWS_FT_FI5

Display surface Download Links