eF-site ID 1nvq-AB PDB Code 1nvq Chain A, B click to enlarge Title The Complex Structure Of Checkpoint Kinase Chk1/UCN-01 Classification TRANSFERASE Compound Serine/threonine-protein kinase Chk1 Source null (1NVQ) Sequence A:  VPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDM KNIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSG GELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHR DIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCG TLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWD QPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVEN PSARITIPDIKKDRWYNKPLKKGA B:  ASVSA Description Functional site 1) chain A residue 54 type sequence K description BINDING SITE FOR RESIDUE SO4 A 500 source : AC1 2) chain A residue 129 type sequence R description BINDING SITE FOR RESIDUE SO4 A 500 source : AC1 3) chain A residue 153 type sequence T description BINDING SITE FOR RESIDUE SO4 A 500 source : AC1 4) chain A residue 15 type sequence L description BINDING SITE FOR RESIDUE UCN A 400 source : AC2 5) chain A residue 16 type sequence G description BINDING SITE FOR RESIDUE UCN A 400 source : AC2 6) chain A residue 20 type sequence Y description BINDING SITE FOR RESIDUE UCN A 400 source : AC2 7) chain A residue 23 type sequence V description BINDING SITE FOR RESIDUE UCN A 400 source : AC2 8) chain A residue 36 type sequence A description BINDING SITE FOR RESIDUE UCN A 400 source : AC2 9) chain A residue 68 type sequence V description BINDING SITE FOR RESIDUE UCN A 400 source : AC2 10) chain A residue 85 type sequence E description BINDING SITE FOR RESIDUE UCN A 400 source : AC2 11) chain A residue 86 type sequence Y description BINDING SITE FOR RESIDUE UCN A 400 source : AC2 12) chain A residue 87 type sequence C description BINDING SITE FOR RESIDUE UCN A 400 source : AC2 13) chain A residue 91 type sequence E description BINDING SITE FOR RESIDUE UCN A 400 source : AC2 14) chain A residue 134 type sequence E description BINDING SITE FOR RESIDUE UCN A 400 source : AC2 15) chain A residue 135 type sequence N description BINDING SITE FOR RESIDUE UCN A 400 source : AC2 16) chain A residue 137 type sequence L description BINDING SITE FOR RESIDUE UCN A 400 source : AC2 17) chain A residue 147 type sequence S description BINDING SITE FOR RESIDUE UCN A 400 source : AC2 18) chain A residue 148 type sequence D description BINDING SITE FOR RESIDUE UCN A 400 source : AC2 19) chain A residue 130 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 20) chain A residue 132 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:32357935 source Swiss-Prot : SWS_FT_FI5 21) chain A residue 15-38 type prosite sequence LGEGAYGEVQLAVNRVTEEAVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAYGEVQlAvnrvteea..........VAVK source prosite : PS00107 22) chain A residue 126-138 type prosite sequence ITHRDIKPENLLL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ItHrDIKpeNLLL source prosite : PS00108 23) chain A residue 38 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 24) chain A residue 15 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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