eF-site ID 1nu9-A PDB Code 1nu9 Chain A click to enlarge Title Staphylocoagulase-Prethrombin-2 complex Classification HYDROLASE/HYDROLASE INHIBITOR Compound Thrombin light and heavy chains Source ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: Homo sapiens; Sequence A:  GEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAE IGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYP PWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHP RYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAAS LLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIV ERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKK WIQKVIDQFG Description (1)  Thrombin light and heavy chains (E.C.3.4.21.5)/Staphylocoagulase Functional site 1) chain A residue 57 type sequence H description BINDING SITE FOR RESIDUE 0ZJ A 299 source : AC1 2) chain A residue 60 type sequence L description BINDING SITE FOR RESIDUE 0ZJ A 299 source : AC1 3) chain A residue 60 type sequence L description BINDING SITE FOR RESIDUE 0ZJ A 299 source : AC1 4) chain A residue 99 type sequence L description BINDING SITE FOR RESIDUE 0ZJ A 299 source : AC1 5) chain A residue 174 type sequence I description BINDING SITE FOR RESIDUE 0ZJ A 299 source : AC1 6) chain A residue 189 type sequence D description BINDING SITE FOR RESIDUE 0ZJ A 299 source : AC1 7) chain A residue 190 type sequence A description BINDING SITE FOR RESIDUE 0ZJ A 299 source : AC1 8) chain A residue 193 type sequence G description BINDING SITE FOR RESIDUE 0ZJ A 299 source : AC1 9) chain A residue 195 type sequence S description BINDING SITE FOR RESIDUE 0ZJ A 299 source : AC1 10) chain A residue 214 type sequence S description BINDING SITE FOR RESIDUE 0ZJ A 299 source : AC1 11) chain A residue 215 type sequence W description BINDING SITE FOR RESIDUE 0ZJ A 299 source : AC1 12) chain A residue 216 type sequence G description BINDING SITE FOR RESIDUE 0ZJ A 299 source : AC1 13) chain A residue 219 type sequence G description BINDING SITE FOR RESIDUE 0ZJ A 299 source : AC1 14) chain A residue 226 type sequence G description BINDING SITE FOR RESIDUE 0ZJ A 299 source : AC1 15) chain A residue 60 type CARBOHYD sequence L description N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923 source Swiss-Prot : SWS_FT_FI3 16) chain A residue 57 type ACT_SITE sequence H description Charge relay system source Swiss-Prot : SWS_FT_FI1 17) chain A residue 102 type ACT_SITE sequence D description Charge relay system source Swiss-Prot : SWS_FT_FI1 18) chain A residue 195 type ACT_SITE sequence S description Charge relay system source Swiss-Prot : SWS_FT_FI1 19) chain A residue 15 type SITE sequence R description Cleavage; by factor Xa => ECO:0000269|PubMed:34265300 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 53-58 type prosite sequence LTAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC source prosite : PS00134 21) chain A residue 189-200 type prosite sequence DACEGDSGGPFV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV source prosite : PS00135

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