eF-site ID 1nsq-ABC PDB Code 1nsq Chain A, B, C click to enlarge Title MECHANISM OF PHOSPHATE TRANSFER BY NUCLEOSIDE DIPHOSPHATE KINASE: X-RAY STRUCTURES OF A PHOSPHO-HISTIDINE INTERMEDIATE OF THE ENZYMES FROM DROSOPHILA AND DICTYOSTELIUM Classification PHOSPHOTRANSFERASE Compound NUCLEOSIDE DIPHOSPHATE KINASE Source Drosophila melanogaster (Fruit fly) (NDKA_DROME) Sequence A:  AANKERTFIMVKPDGVQRGLVGKIIERFEQKGFKLVALKF TWASKELLEKHYADLSARPFFPGLVNYMNSGPVVPMVWEG LNVVKTGRQMLGATNPADSLPGTIRGDFCIQVGRNIIXGS DAVESAEKEIALWFNEKELVTWTPAAKDWIYE B:  AANKERTFIMVKPDGVQRGLVGKIIERFEQKGFKLVALKF TWASKELLEKHYADLSARPFFPGLVNYMNSGPVVPMVWEG LNVVKTGRQMLGATNPADSLPGTIRGDFCIQVGRNIIXGS DAVESAEKEIALWFNEKELVTWTPAAKDWIYE C:  AANKERTFIMVKPDGVQRGLVGKIIERFEQKGFKLVALKF TWASKELLEKHYADLSARPFFPGLVNYMNSGPVVPMVWEG LNVVKTGRQMLGATNPADSLPGTIRGDFCIQVGRNIIXGS DAVESAEKEIALWFNEKELVTWTPAAKDWIYE Description (1)  NUCLEOSIDE DIPHOSPHATE KINASE (E.C.2.7.4.6) Functional site 1) chain A residue 2 type MOD_RES sequence A description N-acetylalanine => ECO:0000269|PubMed:12099695 source Swiss-Prot : SWS_FT_FI3 2) chain B residue 2 type MOD_RES sequence A description N-acetylalanine => ECO:0000269|PubMed:12099695 source Swiss-Prot : SWS_FT_FI3 3) chain C residue 2 type MOD_RES sequence A description N-acetylalanine => ECO:0000269|PubMed:12099695 source Swiss-Prot : SWS_FT_FI3 4) chain A residue 126 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:18327897 source Swiss-Prot : SWS_FT_FI4 5) chain B residue 126 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:18327897 source Swiss-Prot : SWS_FT_FI4 6) chain C residue 126 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:18327897 source Swiss-Prot : SWS_FT_FI4 7) chain A residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI2 8) chain B residue 95 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI2 9) chain B residue 106 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 10) chain B residue 116 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2 11) chain C residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI2 12) chain C residue 61 type BINDING sequence F description source Swiss-Prot : SWS_FT_FI2 13) chain C residue 89 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 14) chain C residue 95 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI2 15) chain C residue 106 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 16) chain C residue 116 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2 17) chain A residue 61 type BINDING sequence F description source Swiss-Prot : SWS_FT_FI2 18) chain A residue 89 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 19) chain A residue 95 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI2 20) chain A residue 106 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 21) chain A residue 116 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2 22) chain B residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI2 23) chain B residue 61 type BINDING sequence F description source Swiss-Prot : SWS_FT_FI2 24) chain B residue 89 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 25) chain A residue 119 type ACT_SITE sequence X description Pros-phosphohistidine intermediate source Swiss-Prot : SWS_FT_FI1 26) chain B residue 119 type ACT_SITE sequence X description Pros-phosphohistidine intermediate source Swiss-Prot : SWS_FT_FI1 27) chain C residue 119 type ACT_SITE sequence X description Pros-phosphohistidine intermediate source Swiss-Prot : SWS_FT_FI1 28) chain A residue 116-124 type prosite sequence NIIXGSDAV description NDPK Nucleoside diphosphate kinase (NDPK) active site signature. NiiHGSDAV source prosite : PS00469

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