|
|
eF-site ID
|
1nrn-HLR |
|
PDB Code
|
1nrn |
|
Chain
|
H, L, R |
|
click to enlarge
|
|
|
Title
|
CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES |
|
Classification
|
SERINE PROTEINASE/RECEPTOR |
|
Compound
|
ALPHA-THROMBIN (SMALL SUBUNIT) |
|
Source
|
null (PAR1_HUMAN) |
|
|
Sequence
|
H: |
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLT
AAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISM
LEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCL
PDRETAASLLQAGYKGRVTGWGNLKEKGQPSVLQVVNLPI
VERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLK
KWIQKVI
|
| L: |
DCGLRPLFEKKSLEDKTERELLESYIDGR
|
| R: |
LDPRSFLLRNPNDKYEPFW
|
|
|
Description
|
(1) |
ALPHA-THROMBIN (E.C.3.4.21.5) NON-COVALENTLY COMPLEXED WITH RECEPTOR BASED PEPTIDE NRS
|
|
Functional site
|
|
|
1)
|
chain |
H |
| residue |
57 |
| type |
|
| sequence |
H
|
| description |
|
| source |
: CAT
|
|
|
2)
|
chain |
H |
| residue |
102 |
| type |
|
| sequence |
D
|
| description |
|
| source |
: CAT
|
|
|
3)
|
chain |
H |
| residue |
195 |
| type |
|
| sequence |
S
|
| description |
|
| source |
: CAT
|
|
|
4)
|
chain |
H |
| residue |
53-58 |
| type |
prosite |
| sequence |
LTAAHC
|
| description |
TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
|
| source |
prosite : PS00134
|
|
|
5)
|
chain |
H |
| residue |
189-200 |
| type |
prosite |
| sequence |
DACEGDSGGPFV
|
| description |
TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV
|
| source |
prosite : PS00135
|
|
|
6)
|
chain |
R |
| residue |
55 |
| type |
SITE |
| sequence |
F
|
| description |
Cleavage; by CTSG => ECO:0000269|PubMed:7744748
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
7)
|
chain |
R |
| residue |
41 |
| type |
SITE |
| sequence |
R
|
| description |
Cleavage; by thrombin and CTSG => ECO:0000269|PubMed:1672265, ECO:0000269|PubMed:7744748
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
8)
|
chain |
H |
| residue |
102 |
| type |
SITE |
| sequence |
D
|
| description |
Cleavage; by thrombin and CTSG => ECO:0000269|PubMed:1672265, ECO:0000269|PubMed:7744748
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
9)
|
chain |
H |
| residue |
195 |
| type |
SITE |
| sequence |
S
|
| description |
Cleavage; by thrombin and CTSG => ECO:0000269|PubMed:1672265, ECO:0000269|PubMed:7744748
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|