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eF-site ID
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1nql-AB |
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PDB Code
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1nql |
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Chain
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A, B |
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click to enlarge
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Title
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Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF. |
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Classification
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HORMONE/GROWTH FACTOR RECEPTOR |
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Compound
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epidermal growth factor receptor |
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Source
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(EGF_HUMAN) |
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Sequence
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A: |
EKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLE
ITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQI
IRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHG
AVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGS
CQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGK
SPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPP
LMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGS
CVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFK
DSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPP
LDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEII
RGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGN
KNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVC
HALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCKLLEGEP
REFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYI
DGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTY
GCTGPGLEGCPT
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| B: |
DSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERC
QYRDLKWW
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Description
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Functional site
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1)
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chain |
A |
| residue |
420 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:8962717, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3B2V, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3P0Y, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRL, ECO:0007744|PDB:4KRM, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP, ECO:0007744|PDB:4UIP, ECO:0007744|PDB:4UV7
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| source |
Swiss-Prot : SWS_FT_FI10
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2)
|
chain |
A |
| residue |
504 |
| type |
CARBOHYD |
| sequence |
N
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| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:25922362, ECO:0000269|PubMed:8962717, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2V, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRP, ECO:0007744|PDB:4UIP, ECO:0007744|PDB:4UV7
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| source |
Swiss-Prot : SWS_FT_FI11
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3)
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chain |
A |
| residue |
544 |
| type |
CARBOHYD |
| sequence |
N
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| description |
N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:10731668, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:19159218, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9
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| source |
Swiss-Prot : SWS_FT_FI12
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|
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4)
|
chain |
A |
| residue |
579 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:10731668, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9
|
| source |
Swiss-Prot : SWS_FT_FI13
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|
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5)
|
chain |
A |
| residue |
599 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) (high mannose) asparagine => ECO:0000305|PubMed:12731890
|
| source |
Swiss-Prot : SWS_FT_FI14
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|
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6)
|
chain |
A |
| residue |
328 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10731668, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:20837704, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1MOX, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3B2V, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3P0Y, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRL, ECO:0007744|PDB:4KRM, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP, ECO:0007744|PDB:4UIP, ECO:0007744|PDB:4UV7
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| source |
Swiss-Prot : SWS_FT_FI7
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|
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7)
|
chain |
A |
| residue |
337 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10731668, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRL, ECO:0007744|PDB:4KRM, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP, ECO:0007744|PDB:4UV7
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| source |
Swiss-Prot : SWS_FT_FI8
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8)
|
chain |
A |
| residue |
389 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:8962717, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3B2V, ECO:0007744|PDB:3P0Y, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP
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| source |
Swiss-Prot : SWS_FT_FI9
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9)
|
chain |
A |
| residue |
151 |
| type |
CARBOHYD |
| sequence |
N
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| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:8962717, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:3NJP
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| source |
Swiss-Prot : SWS_FT_FI5
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10)
|
chain |
A |
| residue |
172 |
| type |
CARBOHYD |
| sequence |
N
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| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1MOX, ECO:0007744|PDB:3NJP
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| source |
Swiss-Prot : SWS_FT_FI6
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|
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11)
|
chain |
A |
| residue |
205 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000269|PubMed:21487020
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| source |
Swiss-Prot : SWS_FT_FI1
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12)
|
chain |
A |
| residue |
32 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) (complex) asparagine; atypical; partial => ECO:0000269|PubMed:10731668, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1MOX, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3QWQ
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| source |
Swiss-Prot : SWS_FT_FI2
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13)
|
chain |
A |
| residue |
49 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine; atypical => ECO:0000269|PubMed:20837704, ECO:0007744|PDB:3NJP
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| source |
Swiss-Prot : SWS_FT_FI3
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14)
|
chain |
A |
| residue |
104 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:8962717
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| source |
Swiss-Prot : SWS_FT_FI4
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15)
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chain |
B |
| residue |
31-42 |
| type |
prosite |
| sequence |
CNCVVGYIGERC
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| description |
EGF_1 EGF-like domain signature 1. CnCvvGyiGErC
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| source |
prosite : PS00022
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16)
|
chain |
B |
| residue |
31-42 |
| type |
prosite |
| sequence |
CNCVVGYIGERC
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| description |
EGF_2 EGF-like domain signature 2. CnCvvGYiger....C
|
| source |
prosite : PS01186
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