|
|
eF-site ID
|
1nmc-ABC |
|
PDB Code
|
1nmc |
|
Chain
|
A, B, C |
|
click to enlarge
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Title
|
COMPLEX BETWEEN NC10 ANTI-INFLUENZA VIRUS NEURAMINIDASE SINGLE CHAIN ANTIBODY WITH A 15 RESIDUE LINKER AND INFLUENZA VIRUS NEURAMINIDASE |
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Classification
|
COMPLEX (SINGLE-CHAIN ANTIBODY/ANTIGEN) |
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Compound
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NEURAMINIDASE |
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Source
|
(AAA19165) |
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Sequence
|
A: |
RDFNNLTKGLCTINSWHIYGKDNAVRIGEDSDVLVTREPY
VSCDPDECRFYALSQGTTIRGKHSNGTIHDRSQYRALISW
PLSSPPTVYNSRVECIGWSSTSCHDGKTRMSICISGPNNN
ASAVIWYNRRPVTEINTWARNILRTQESECVCHNGVCPVV
FTDGSATGPAETRIYYFKEGKILKWEPLAGTAKHIEECSC
YGERAEITCTCRDNWQGSNRPVIRIDPVAMTHTSQYICSP
VLTDNPRPNDPTVGKCNDPYPGNNNNGVKGFSYLDGVNTW
LGRTISIASRSGYEMLKVPNALTDDKSKPTQGQTIVLNTD
WSGYSGSFMDYWAEGECYRACFYVELIRGRPKEDKVWWTS
NSIVSMCSSTEFLGQWDWPDGAKIEYFL
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| B: |
QVQLQQSGAELVKPGASVRMSCKASGYTFTNYNMYWVKQS
PGQGLEWIGIFYPGNGDTSYNQKFKDKATLTADKSSNTAY
MQLSSLTSEDSAVYYCARSGGSYRYDGGFDYWGQGTTVTV
SS
|
| C: |
DIELTQTTSSLSASLGDRVTISCRASQDISNYLNWYQQNP
DGTVKLLIYYTSNLHSEVPSRFSGSGSGTDYSLTISNLEQ
EDIATYFCQQDFTLPFTFGGGTKLEIRDY
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Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
151 |
| type |
catalytic |
| sequence |
D
|
| description |
828
|
| source |
MCSA : MCSA2
|
|
|
2)
|
chain |
A |
| residue |
277 |
| type |
catalytic |
| sequence |
E
|
| description |
828
|
| source |
MCSA : MCSA2
|
|
|
3)
|
chain |
A |
| residue |
292 |
| type |
catalytic |
| sequence |
R
|
| description |
828
|
| source |
MCSA : MCSA2
|
|
|
4)
|
chain |
A |
| residue |
371 |
| type |
catalytic |
| sequence |
R
|
| description |
828
|
| source |
MCSA : MCSA2
|
|
|
5)
|
chain |
A |
| residue |
406 |
| type |
catalytic |
| sequence |
Y
|
| description |
828
|
| source |
MCSA : MCSA2
|
|
|
6)
|
chain |
A |
| residue |
151 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04071
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
A |
| residue |
406 |
| type |
ACT_SITE |
| sequence |
Y
|
| description |
Nucleophile => ECO:0000255|HAMAP-Rule:MF_04071
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
8)
|
chain |
A |
| residue |
371 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000255|HAMAP-Rule:MF_04071
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
9)
|
chain |
A |
| residue |
118 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000255|HAMAP-Rule:MF_04071
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
10)
|
chain |
A |
| residue |
152 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000255|HAMAP-Rule:MF_04071
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
11)
|
chain |
A |
| residue |
276 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000255|HAMAP-Rule:MF_04071
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
12)
|
chain |
A |
| residue |
292 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000255|HAMAP-Rule:MF_04071
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
13)
|
chain |
A |
| residue |
293 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:23429702, ECO:0000269|PubMed:7549872, ECO:0000269|PubMed:8371267, ECO:0000269|PubMed:9342319
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
14)
|
chain |
A |
| residue |
297 |
| type |
BINDING |
| sequence |
G
|
| description |
BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:23429702, ECO:0000269|PubMed:7549872, ECO:0000269|PubMed:8371267, ECO:0000269|PubMed:9342319
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
15)
|
chain |
A |
| residue |
324 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:23429702, ECO:0000269|PubMed:7549872, ECO:0000269|PubMed:8371267, ECO:0000269|PubMed:9342319
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
16)
|
chain |
A |
| residue |
347 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:23429702, ECO:0000269|PubMed:7549872, ECO:0000269|PubMed:8371267, ECO:0000269|PubMed:9342319
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
17)
|
chain |
A |
| residue |
86 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:23429702, ECO:0000269|PubMed:7549872, ECO:0000269|PubMed:9342319
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
18)
|
chain |
A |
| residue |
146 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:23429702, ECO:0000269|PubMed:7549872, ECO:0000269|PubMed:9342319
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
19)
|
chain |
A |
| residue |
200 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:23429702, ECO:0000269|PubMed:7549872, ECO:0000269|PubMed:9342319
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
|