eF-site ID 1nl4-AB PDB Code 1nl4 Chain A, B click to enlarge Title Crystal Structure of Rat Farnesyl Transferase in Complex With A Potent Biphenyl Inhibitor Classification TRANSFERASE Compound Protein farnesyltransferase alpha subunit Source Rattus norvegicus (Rat) (PFTB_RAT) Sequence A:  FLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSE KFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVW HFRRVLLRSLQKDLQEEMNYITAIIEEQPKNYQVWHHRRV LVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFR LWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRA VLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPN LLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDIL NKALELCEILAKEKDTIRKEYWRYIGRSLQSK B:  LYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSY KFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPW LCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGG GPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLY SLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLF EGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVIL KKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSF WQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMC CQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAML HDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPG F Description Functional site 1) chain B residue 297 type sequence D description BINDING SITE FOR RESIDUE ZN B 500 source : AC1 2) chain B residue 299 type sequence C description BINDING SITE FOR RESIDUE ZN B 500 source : AC1 3) chain B residue 362 type sequence H description BINDING SITE FOR RESIDUE ZN B 500 source : AC1 4) chain A residue 164 type sequence K description BINDING SITE FOR RESIDUE HFP B 501 source : AC2 5) chain A residue 166 type sequence Y description BINDING SITE FOR RESIDUE HFP B 501 source : AC2 6) chain B residue 102 type sequence W description BINDING SITE FOR RESIDUE HFP B 501 source : AC2 7) chain B residue 205 type sequence Y description BINDING SITE FOR RESIDUE HFP B 501 source : AC2 8) chain B residue 248 type sequence H description BINDING SITE FOR RESIDUE HFP B 501 source : AC2 9) chain B residue 251 type sequence Y description BINDING SITE FOR RESIDUE HFP B 501 source : AC2 10) chain B residue 291 type sequence R description BINDING SITE FOR RESIDUE HFP B 501 source : AC2 11) chain B residue 300 type sequence Y description BINDING SITE FOR RESIDUE HFP B 501 source : AC2 12) chain B residue 303 type sequence W description BINDING SITE FOR RESIDUE HFP B 501 source : AC2 13) chain B residue 361 type sequence Y description BINDING SITE FOR RESIDUE HFP B 501 source : AC2 14) chain A residue 166 type sequence Y description BINDING SITE FOR RESIDUE FTL B 1 source : AC3 15) chain B residue 102 type sequence W description BINDING SITE FOR RESIDUE FTL B 1 source : AC3 16) chain B residue 106 type sequence W description BINDING SITE FOR RESIDUE FTL B 1 source : AC3 17) chain B residue 297 type sequence D description BINDING SITE FOR RESIDUE FTL B 1 source : AC3 18) chain B residue 352 type sequence D description BINDING SITE FOR RESIDUE FTL B 1 source : AC3 19) chain B residue 359 type sequence D description BINDING SITE FOR RESIDUE FTL B 1 source : AC3 20) chain B residue 360 type sequence F description BINDING SITE FOR RESIDUE FTL B 1 source : AC3 21) chain B residue 361 type sequence Y description BINDING SITE FOR RESIDUE FTL B 1 source : AC3 22) chain B residue 362 type sequence H description BINDING SITE FOR RESIDUE FTL B 1 source : AC3 23) chain B residue 248 type catalytic sequence H description 484 source MCSA : MCSA1 24) chain B residue 291 type catalytic sequence R description 484 source MCSA : MCSA1 25) chain B residue 294 type catalytic sequence K description 484 source MCSA : MCSA1 26) chain B residue 297 type catalytic sequence D description 484 source MCSA : MCSA1 27) chain B residue 299 type catalytic sequence C description 484 source MCSA : MCSA1 28) chain B residue 300 type catalytic sequence Y description 484 source MCSA : MCSA1 29) chain B residue 352 type catalytic sequence D description 484 source MCSA : MCSA1 30) chain B residue 359 type catalytic sequence D description 484 source MCSA : MCSA1 31) chain B residue 362 type catalytic sequence H description 484 source MCSA : MCSA1 32) chain B residue 248 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI1 33) chain B residue 291 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 34) chain B residue 300 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI1 35) chain B residue 297 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18844669, ECO:0000269|PubMed:20056542, ECO:0000269|PubMed:9065406 source Swiss-Prot : SWS_FT_FI2 36) chain B residue 299 type BINDING sequence C description BINDING => ECO:0000269|PubMed:18844669, ECO:0000269|PubMed:20056542, ECO:0000269|PubMed:9065406 source Swiss-Prot : SWS_FT_FI2 37) chain B residue 362 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18844669, ECO:0000269|PubMed:20056542, ECO:0000269|PubMed:9065406 source Swiss-Prot : SWS_FT_FI2 38) chain B residue 102 type SITE sequence W description Important for selectivity against geranylgeranyl diphosphate => ECO:0000250|UniProtKB:P49356 source Swiss-Prot : SWS_FT_FI3

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