|
|
eF-site ID
|
1nl4-A |
|
PDB Code
|
1nl4 |
|
Chain
|
A |
|
click to enlarge
|
|
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Title
|
Crystal Structure of Rat Farnesyl Transferase in Complex With A Potent Biphenyl Inhibitor |
|
Classification
|
TRANSFERASE |
|
Compound
|
Protein farnesyltransferase alpha subunit |
|
Source
|
Rattus norvegicus (Rat) (PFTB_RAT) |
|
|
Sequence
|
A: |
FLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSE
KFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVW
HFRRVLLRSLQKDLQEEMNYITAIIEEQPKNYQVWHHRRV
LVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFR
LWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRA
VLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPN
LLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDIL
NKALELCEILAKEKDTIRKEYWRYIGRSLQSK
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
164 |
| type |
|
| sequence |
K
|
| description |
BINDING SITE FOR RESIDUE HFP B 501
|
| source |
: AC2
|
|
|
2)
|
chain |
A |
| residue |
166 |
| type |
|
| sequence |
Y
|
| description |
BINDING SITE FOR RESIDUE HFP B 501
|
| source |
: AC2
|
|
|
3)
|
chain |
A |
| residue |
166 |
| type |
|
| sequence |
Y
|
| description |
BINDING SITE FOR RESIDUE FTL B 1
|
| source |
: AC3
|
|
|
|