eF-site ID 1nhv-B PDB Code 1nhv Chain B click to enlarge Title Hepatitis C virus RNA polymerase in complex with non-nucleoside analogue inhibitor Classification TRANSFERASE Compound HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE Source Hepatitis C virus genotype 1b (isolate BK) (HCV) (POLG_HCVBK) Sequence B:  SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYAT TSRSAGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA KLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIH SVWKDLLEDTVTPIDTTIMAKNEVFCVQRKPARLIVFPDL GVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQRVEFLV NTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCDL APEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVL TTSCGNTLTCYLKASAACRAAKLQDCTMLVNGDDLVVICE SAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYDLELITS CSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPV NSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDC QIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRV ASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYL FNWAVKTKLKLTPIPAASQLDLSGWFVAGYSGGDIYHSLS R Description Functional site 1) chain B residue 422 type sequence R description BINDING SITE FOR RESIDUE 154 B 6001 source : AC2 2) chain B residue 423 type sequence M description BINDING SITE FOR RESIDUE 154 B 6001 source : AC2 3) chain B residue 474 type sequence L description BINDING SITE FOR RESIDUE 154 B 6001 source : AC2 4) chain B residue 475 type sequence H description BINDING SITE FOR RESIDUE 154 B 6001 source : AC2 5) chain B residue 476 type sequence S description BINDING SITE FOR RESIDUE 154 B 6001 source : AC2 6) chain B residue 477 type sequence Y description BINDING SITE FOR RESIDUE 154 B 6001 source : AC2 7) chain B residue 482 type sequence I description BINDING SITE FOR RESIDUE 154 B 6001 source : AC2 8) chain B residue 497 type sequence L description BINDING SITE FOR RESIDUE 154 B 6001 source : AC2 9) chain B residue 528 type sequence W description BINDING SITE FOR RESIDUE 154 B 6001 source : AC2 10) chain B residue 220 type BINDING sequence D description BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572 source Swiss-Prot : SWS_FT_FI1 11) chain B residue 318 type BINDING sequence D description BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572 source Swiss-Prot : SWS_FT_FI1 12) chain B residue 319 type BINDING sequence D description BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572 source Swiss-Prot : SWS_FT_FI1 13) chain B residue 29 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2 14) chain B residue 42 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2

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