eF-site ID 1nhu-A PDB Code 1nhu Chain A click to enlarge Title Hepatitis C virus RNA polymerase in complex with non-nucleoside analogue inhibitor Classification TRANSFERASE Compound HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE Source Hepatitis C virus genotype 1b (isolate BK) (HCV) (POLG_HCVBK) Sequence A:  SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYAT TSRSAGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA KLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIH SVWKDLLEDTVTPIDTTIMAKNEVFCVQRKPARLIVFPDL GVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQRVEFLV NTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCDL APEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVL TTSCGNTLTCYLKASAACRAAKLQDCTMLVNGDDLVVICE SAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYDLELITS CSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPV NSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDC QIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRV ASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYL FNWAVKTKLKLTPIPAASQLDLSGWFVAGYSGGDIYHS Description Functional site 1) chain A residue 422 type sequence R description BINDING SITE FOR RESIDUE 153 A 5001 source : AC1 2) chain A residue 423 type sequence M description BINDING SITE FOR RESIDUE 153 A 5001 source : AC1 3) chain A residue 474 type sequence L description BINDING SITE FOR RESIDUE 153 A 5001 source : AC1 4) chain A residue 476 type sequence S description BINDING SITE FOR RESIDUE 153 A 5001 source : AC1 5) chain A residue 477 type sequence Y description BINDING SITE FOR RESIDUE 153 A 5001 source : AC1 6) chain A residue 497 type sequence L description BINDING SITE FOR RESIDUE 153 A 5001 source : AC1 7) chain A residue 501 type sequence R description BINDING SITE FOR RESIDUE 153 A 5001 source : AC1 8) chain A residue 528 type sequence W description BINDING SITE FOR RESIDUE 153 A 5001 source : AC1 9) chain A residue 220 type BINDING sequence D description BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572 source Swiss-Prot : SWS_FT_FI1 10) chain A residue 318 type BINDING sequence D description BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572 source Swiss-Prot : SWS_FT_FI1 11) chain A residue 319 type BINDING sequence D description BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572 source Swiss-Prot : SWS_FT_FI1 12) chain A residue 29 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2 13) chain A residue 42 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2

Display surface Download Links