eF-site ID 1ngd-A PDB Code 1ngd Chain A click to enlarge Title STRUCTURAL BASIS OF THE 70-KILODALTON HEAT SHOCK COGNATE PROTEIN ATP HYDROLYTIC ACTIVITY, II. STRUCTURE OF THE ACTIVE SITE WITH ADP OR ATP BOUND TO WILD TYPE AND MUTANT ATPASE FRAGMENT Classification HYDROLASE(ACTING ON ACID ANHYDRIDES) Compound HEAT-SHOCK COGNATE 70 kD PROTEIN Source null (HSP7C_BOVIN) Sequence A:  GPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVA FTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVV QSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMV LTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGT IAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGG TFNVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIA EFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIE IDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRD AKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSI NPDEAVAYGAAVQAAILS Description Functional site 1) chain A residue 12 type sequence G description BINDING SITE FOR RESIDUE PO4 A 488 source : AC2 2) chain A residue 13 type sequence T description BINDING SITE FOR RESIDUE PO4 A 488 source : AC2 3) chain A residue 71 type sequence K description BINDING SITE FOR RESIDUE PO4 A 488 source : AC2 4) chain A residue 147 type sequence P description BINDING SITE FOR RESIDUE PO4 A 488 source : AC2 5) chain A residue 175 type sequence E description BINDING SITE FOR RESIDUE PO4 A 488 source : AC2 6) chain A residue 204 type sequence T description BINDING SITE FOR RESIDUE PO4 A 488 source : AC2 7) chain A residue 13 type sequence T description BINDING SITE FOR RESIDUE ADP A 486 source : AC3 8) chain A residue 14 type sequence T description BINDING SITE FOR RESIDUE ADP A 486 source : AC3 9) chain A residue 15 type sequence Y description BINDING SITE FOR RESIDUE ADP A 486 source : AC3 10) chain A residue 201 type sequence G description BINDING SITE FOR RESIDUE ADP A 486 source : AC3 11) chain A residue 202 type sequence G description BINDING SITE FOR RESIDUE ADP A 486 source : AC3 12) chain A residue 230 type sequence G description BINDING SITE FOR RESIDUE ADP A 486 source : AC3 13) chain A residue 268 type sequence E description BINDING SITE FOR RESIDUE ADP A 486 source : AC3 14) chain A residue 271 type sequence K description BINDING SITE FOR RESIDUE ADP A 486 source : AC3 15) chain A residue 272 type sequence R description BINDING SITE FOR RESIDUE ADP A 486 source : AC3 16) chain A residue 275 type sequence S description BINDING SITE FOR RESIDUE ADP A 486 source : AC3 17) chain A residue 338 type sequence G description BINDING SITE FOR RESIDUE ADP A 486 source : AC3 18) chain A residue 339 type sequence G description BINDING SITE FOR RESIDUE ADP A 486 source : AC3 19) chain A residue 340 type sequence S description BINDING SITE FOR RESIDUE ADP A 486 source : AC3 20) chain A residue 342 type sequence R description BINDING SITE FOR RESIDUE ADP A 486 source : AC3 21) chain A residue 343 type sequence I description BINDING SITE FOR RESIDUE ADP A 486 source : AC3 22) chain A residue 366 type sequence D description BINDING SITE FOR RESIDUE ADP A 486 source : AC3 23) chain A residue 319 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P63017 source Swiss-Prot : SWS_FT_FI7 24) chain A residue 108 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P63017 source Swiss-Prot : SWS_FT_FI4 25) chain A residue 328 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P63017 source Swiss-Prot : SWS_FT_FI4 26) chain A residue 329 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P11142 source Swiss-Prot : SWS_FT_FI5 27) chain A residue 362 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P11142 source Swiss-Prot : SWS_FT_FI5 28) chain A residue 153 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P11142 source Swiss-Prot : SWS_FT_FI5 29) chain A residue 246 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P11142 source Swiss-Prot : SWS_FT_FI6 30) chain A residue 10 type catalytic sequence D description 656 source MCSA : MCSA1 31) chain A residue 71 type catalytic sequence K description 656 source MCSA : MCSA1 32) chain A residue 175 type catalytic sequence E description 656 source MCSA : MCSA1 33) chain A residue 199 type catalytic sequence D description 656 source MCSA : MCSA1 34) chain A residue 9-16 type prosite sequence IDLGTTYS description HSP70_1 Heat shock hsp70 proteins family signature 1. IDLGTTyS source prosite : PS00297 35) chain A residue 197-210 type prosite sequence IFDLGGGTFNVSIL description HSP70_2 Heat shock hsp70 proteins family signature 2. IFDLGGGTfnvSIL source prosite : PS00329 36) chain A residue 334-348 type prosite sequence IVLVGGSTRIPKIQK description HSP70_3 Heat shock hsp70 proteins family signature 3. IvLvGGsTRIPkIqK source prosite : PS01036 37) chain A residue 12 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 38) chain A residue 71 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI1 39) chain A residue 15 type BINDING sequence Y description BINDING => ECO:0007744|PDB:2QWL, ECO:0007744|PDB:2QWM, ECO:0007744|PDB:2QWN, ECO:0007744|PDB:2QWO, ECO:0007744|PDB:2QWP, ECO:0007744|PDB:2QWQ source Swiss-Prot : SWS_FT_FI2 40) chain A residue 202 type BINDING sequence G description BINDING => ECO:0007744|PDB:2QWL, ECO:0007744|PDB:2QWM, ECO:0007744|PDB:2QWN, ECO:0007744|PDB:2QWO, ECO:0007744|PDB:2QWP, ECO:0007744|PDB:2QWQ source Swiss-Prot : SWS_FT_FI2 41) chain A residue 268 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QWL, ECO:0007744|PDB:2QWM, ECO:0007744|PDB:2QWN, ECO:0007744|PDB:2QWO, ECO:0007744|PDB:2QWP, ECO:0007744|PDB:2QWQ source Swiss-Prot : SWS_FT_FI2 42) chain A residue 271 type BINDING sequence K description BINDING => ECO:0007744|PDB:2QWL, ECO:0007744|PDB:2QWM, ECO:0007744|PDB:2QWN, ECO:0007744|PDB:2QWO, ECO:0007744|PDB:2QWP, ECO:0007744|PDB:2QWQ source Swiss-Prot : SWS_FT_FI2 43) chain A residue 275 type BINDING sequence S description BINDING => ECO:0007744|PDB:2QWL, ECO:0007744|PDB:2QWM, ECO:0007744|PDB:2QWN, ECO:0007744|PDB:2QWO, ECO:0007744|PDB:2QWP, ECO:0007744|PDB:2QWQ source Swiss-Prot : SWS_FT_FI2 44) chain A residue 339 type BINDING sequence G description BINDING => ECO:0007744|PDB:2QWL, ECO:0007744|PDB:2QWM, ECO:0007744|PDB:2QWN, ECO:0007744|PDB:2QWO, ECO:0007744|PDB:2QWP, ECO:0007744|PDB:2QWQ source Swiss-Prot : SWS_FT_FI2 45) chain A residue 14 type BINDING sequence T description BINDING => ECO:0007744|PDB:2QWL, ECO:0007744|PDB:2QWM, ECO:0007744|PDB:2QWN, ECO:0007744|PDB:2QWO, ECO:0007744|PDB:2QWP, ECO:0007744|PDB:2QWQ source Swiss-Prot : SWS_FT_FI2

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