eF-site ID 1nek-ABCD PDB Code 1nek Chain A, B, C, D click to enlarge Title Complex II (Succinate Dehydrogenase) From E. Coli with ubiquinone bound Classification OXIDOREDUCTASE/ELECTRON TRANSPORT Compound Succinate dehydrogenase flavoprotein subunit Source null (DHSD_ECOLI) Sequence A:  MKLPVREFDAVVIGAGGAGMRAALQISQSGQTCALLSKVF PTRSHTVSAQGGITVALGNTHEDNWEWHMYDTVKGSDYIG DQDAIEYMCKTGPEAILELEHMGLPFSRLDDGRIYQRPFG GQSKNFGGEQAARTAAAADRTGHALLHTLYQQNLKNHTTI FSEWYALDLVKNQDGAVVGCTALCIETGEVVYFKARATVL ATGGAGRIYQSTTNAHINTGDGVGMAIRAGVPVQDMEMWQ FHPTGIAGAGVLVTEGCRGEGGYLLNKHGERFMERYAPNA KDLAGRDVVARSIMIEIREGRGCDGPWGPHAKLKLDHLGK EVLESRLPGILELSRTFAHVDPVKEPIPVIPTCHYMMGGI PTKVTGQALTVNEKGEDVVVPGLFAVGEIACVSVHGANRL GGNSLLDLVVFGRAAGLHLQESIAEQGALRDASESDVEAS LDRLNRWNNNRNGEDPVAIRKALQECMQHNFSVFREGDAM AKGLEQLKVIRERLKNARLDDTSSEFNTQRVECLELDNLM ETAYATAVSANFRTESRGAHSRFDFPDRDDENWLCHSLYL PESESMTRRSVNMEPKLRPAFPPKIRTY B:  MRLEFSIYRYNPDVDDAPRMQDYTLEADEGRDMMLLDALI QLKEKDPSLSFRRSCREGVCGSDGLNMNGKNGLACITPIS ALNQPGKKIVIRPLPGLPVIRDLVVDMGQFYAQYEKIKPY LLNNGQNPPAREHLQMPEQREKLDGLYECILCACCSTSCP SFWWNPDKFIGPAGLLAAYRFLIDSRDTETDSRLDGLSDA FSVFRCHSIMNCVSVCPKGLNPTRAIGHIKSMLLQRNA C:  MIRNVKKQRPVNLDLQTIRFPITAIASILHRVSGVITFVA VGILLWLLGTSLSSPEGFEQASAIMGSFFVKFIMWGILTA LAYHVVVGIRHMMMDFGYLEETFEAGKRSAKISFVITVVL SLLAGVLVW D:  SNASALGRNGVHDFILVRATAIVLTLYIIYMVGFFATSGE LTYEVWIGFFASAFTKVFTLLALFSILIHAWIGMWQVLTD YVKPLALRLMLQLVIVVALVVYVIYGFVVVWGV Description (1)  Succinate dehydrogenase flavoprotein subunit (E.C.1.3.99.1, 1.3.5.1), Succinate dehydrogenase iron-sulfur protein(E.C.1.3.99.1, 1.3.5.1), Succinate dehydrogenase cytochrome b-556 subunit, Succinate dehydrogenase hydrophobic membrane anchor protein Functional site 1) chain A residue 51 type sequence G description BINDING SITE FOR RESIDUE OAA A 589 source : AC1 2) chain A residue 126 type sequence F description BINDING SITE FOR RESIDUE OAA A 589 source : AC1 3) chain A residue 242 type sequence H description BINDING SITE FOR RESIDUE OAA A 589 source : AC1 4) chain A residue 254 type sequence T description BINDING SITE FOR RESIDUE OAA A 589 source : AC1 5) chain A residue 255 type sequence E description BINDING SITE FOR RESIDUE OAA A 589 source : AC1 6) chain A residue 286 type sequence R description BINDING SITE FOR RESIDUE OAA A 589 source : AC1 7) chain A residue 354 type sequence H description BINDING SITE FOR RESIDUE OAA A 589 source : AC1 8) chain A residue 399 type sequence R description BINDING SITE FOR RESIDUE OAA A 589 source : AC1 9) chain A residue 401 type sequence G description BINDING SITE FOR RESIDUE OAA A 589 source : AC1 10) chain A residue 402 type sequence G description BINDING SITE FOR RESIDUE OAA A 589 source : AC1 11) chain A residue 355 type sequence Y description BINDING SITE FOR RESIDUE CA A 590 source : AC2 12) chain A residue 356 type sequence M description BINDING SITE FOR RESIDUE CA A 590 source : AC2 13) chain A residue 357 type sequence M description BINDING SITE FOR RESIDUE CA A 590 source : AC2 14) chain A residue 358 type sequence G description BINDING SITE FOR RESIDUE CA A 590 source : AC2 15) chain A residue 388 type sequence E description BINDING SITE FOR RESIDUE CA A 590 source : AC2 16) chain A residue 390 type sequence A description BINDING SITE FOR RESIDUE CA A 590 source : AC2 17) chain B residue 187 type sequence D description BINDING SITE FOR RESIDUE CA B 311 source : AC3 18) chain B residue 190 type sequence T description BINDING SITE FOR RESIDUE CA B 311 source : AC3 19) chain A residue 14 type sequence G description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 20) chain A residue 15 type sequence A description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 21) chain A residue 16 type sequence G description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 22) chain A residue 17 type sequence G description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 23) chain A residue 18 type sequence A description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 24) chain A residue 37 type sequence S description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 25) chain A residue 38 type sequence K description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 26) chain A residue 44 type sequence S description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 27) chain A residue 45 type sequence H description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 28) chain A residue 46 type sequence T description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 29) chain A residue 48 type sequence S description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 30) chain A residue 49 type sequence A description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 31) chain A residue 50 type sequence Q description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 32) chain A residue 51 type sequence G description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 33) chain A residue 52 type sequence G description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 34) chain A residue 164 type sequence W description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 35) chain A residue 165 type sequence Y description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 36) chain A residue 166 type sequence A description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 37) chain A residue 201 type sequence A description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 38) chain A residue 202 type sequence T description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 39) chain A residue 203 type sequence G description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 40) chain A residue 213 type sequence T description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 41) chain A residue 214 type sequence N description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 42) chain A residue 221 type sequence D description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 43) chain A residue 252 type sequence L description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 44) chain A residue 355 type sequence Y description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 45) chain A residue 387 type sequence G description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 46) chain A residue 388 type sequence E description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 47) chain A residue 399 type sequence R description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 48) chain A residue 402 type sequence G description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 49) chain A residue 403 type sequence N description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 50) chain A residue 404 type sequence S description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 51) chain A residue 405 type sequence L description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 52) chain A residue 408 type sequence L description BINDING SITE FOR RESIDUE FAD A 601 source : AC4 53) chain B residue 54 type sequence S description BINDING SITE FOR RESIDUE FES B 302 source : AC5 54) chain B residue 55 type sequence C description BINDING SITE FOR RESIDUE FES B 302 source : AC5 55) chain B residue 56 type sequence R description BINDING SITE FOR RESIDUE FES B 302 source : AC5 56) chain B residue 58 type sequence G description BINDING SITE FOR RESIDUE FES B 302 source : AC5 57) chain B residue 59 type sequence V description BINDING SITE FOR RESIDUE FES B 302 source : AC5 58) chain B residue 60 type sequence C description BINDING SITE FOR RESIDUE FES B 302 source : AC5 59) chain B residue 61 type sequence G description BINDING SITE FOR RESIDUE FES B 302 source : AC5 60) chain B residue 63 type sequence D description BINDING SITE FOR RESIDUE FES B 302 source : AC5 61) chain B residue 75 type sequence C description BINDING SITE FOR RESIDUE FES B 302 source : AC5 62) chain B residue 149 type sequence C description BINDING SITE FOR RESIDUE SF4 B 303 source : AC6 63) chain B residue 150 type sequence I description BINDING SITE FOR RESIDUE SF4 B 303 source : AC6 64) chain B residue 152 type sequence C description BINDING SITE FOR RESIDUE SF4 B 303 source : AC6 65) chain B residue 153 type sequence A description BINDING SITE FOR RESIDUE SF4 B 303 source : AC6 66) chain B residue 155 type sequence C description BINDING SITE FOR RESIDUE SF4 B 303 source : AC6 67) chain B residue 173 type sequence A description BINDING SITE FOR RESIDUE SF4 B 303 source : AC6 68) chain B residue 216 type sequence C description BINDING SITE FOR RESIDUE SF4 B 303 source : AC6 69) chain B residue 220 type sequence L description BINDING SITE FOR RESIDUE SF4 B 303 source : AC6 70) chain B residue 159 type sequence C description BINDING SITE FOR RESIDUE F3S B 304 source : AC7 71) chain B residue 172 type sequence P description BINDING SITE FOR RESIDUE F3S B 304 source : AC7 72) chain B residue 206 type sequence C description BINDING SITE FOR RESIDUE F3S B 304 source : AC7 73) chain B residue 207 type sequence H description BINDING SITE FOR RESIDUE F3S B 304 source : AC7 74) chain B residue 208 type sequence S description BINDING SITE FOR RESIDUE F3S B 304 source : AC7 75) chain B residue 209 type sequence I description BINDING SITE FOR RESIDUE F3S B 304 source : AC7 76) chain B residue 210 type sequence M description BINDING SITE FOR RESIDUE F3S B 304 source : AC7 77) chain B residue 211 type sequence N description BINDING SITE FOR RESIDUE F3S B 304 source : AC7 78) chain B residue 212 type sequence C description BINDING SITE FOR RESIDUE F3S B 304 source : AC7 79) chain B residue 223 type sequence T description BINDING SITE FOR RESIDUE F3S B 304 source : AC7 80) chain B residue 207 type sequence H description BINDING SITE FOR RESIDUE HEM C 305 source : AC8 81) chain C residue 30 type sequence H description BINDING SITE FOR RESIDUE HEM C 305 source : AC8 82) chain C residue 31 type sequence R description BINDING SITE FOR RESIDUE HEM C 305 source : AC8 83) chain C residue 34 type sequence G description BINDING SITE FOR RESIDUE HEM C 305 source : AC8 84) chain C residue 37 type sequence T description BINDING SITE FOR RESIDUE HEM C 305 source : AC8 85) chain C residue 38 type sequence F description BINDING SITE FOR RESIDUE HEM C 305 source : AC8 86) chain C residue 84 type sequence H description BINDING SITE FOR RESIDUE HEM C 305 source : AC8 87) chain C residue 85 type sequence V description BINDING SITE FOR RESIDUE HEM C 305 source : AC8 88) chain C residue 88 type sequence G description BINDING SITE FOR RESIDUE HEM C 305 source : AC8 89) chain C residue 89 type sequence I description BINDING SITE FOR RESIDUE HEM C 305 source : AC8 90) chain D residue 23 type sequence A description BINDING SITE FOR RESIDUE HEM C 305 source : AC8 91) chain D residue 27 type sequence T description BINDING SITE FOR RESIDUE HEM C 305 source : AC8 92) chain D residue 68 type sequence I description BINDING SITE FOR RESIDUE HEM C 305 source : AC8 93) chain D residue 71 type sequence H description BINDING SITE FOR RESIDUE HEM C 305 source : AC8 94) chain D residue 75 type sequence G description BINDING SITE FOR RESIDUE HEM C 305 source : AC8 95) chain D residue 76 type sequence M description BINDING SITE FOR RESIDUE HEM C 305 source : AC8 96) chain D residue 78 type sequence Q description BINDING SITE FOR RESIDUE HEM C 305 source : AC8 97) chain B residue 164 type sequence W description BINDING SITE FOR RESIDUE UQ2 D 306 source : AC9 98) chain B residue 209 type sequence I description BINDING SITE FOR RESIDUE UQ2 D 306 source : AC9 99) chain C residue 15 type sequence L description BINDING SITE FOR RESIDUE UQ2 D 306 source : AC9 100) chain C residue 20 type sequence F description BINDING SITE FOR RESIDUE UQ2 D 306 source : AC9 101) chain C residue 27 type sequence S description BINDING SITE FOR RESIDUE UQ2 D 306 source : AC9 102) chain C residue 28 type sequence I description BINDING SITE FOR RESIDUE UQ2 D 306 source : AC9 103) chain D residue 83 type sequence Y description BINDING SITE FOR RESIDUE UQ2 D 306 source : AC9 104) chain C residue 41 type sequence V description BINDING SITE FOR RESIDUE CDN C 308 source : BC1 105) chain C residue 44 type sequence L description BINDING SITE FOR RESIDUE CDN C 308 source : BC1 106) chain C residue 51 type sequence S description BINDING SITE FOR RESIDUE CDN C 308 source : BC1 107) chain C residue 61 type sequence A description BINDING SITE FOR RESIDUE CDN C 308 source : BC1 108) chain C residue 62 type sequence S description BINDING SITE FOR RESIDUE CDN C 308 source : BC1 109) chain C residue 78 type sequence L description BINDING SITE FOR RESIDUE CDN C 308 source : BC1 110) chain C residue 115 type sequence V description BINDING SITE FOR RESIDUE CDN C 308 source : BC1 111) chain C residue 123 type sequence L description BINDING SITE FOR RESIDUE CDN C 308 source : BC1 112) chain C residue 126 type sequence V description BINDING SITE FOR RESIDUE CDN C 308 source : BC1 113) chain C residue 127 type sequence L description BINDING SITE FOR RESIDUE CDN C 308 source : BC1 114) chain C residue 129 type sequence W description BINDING SITE FOR RESIDUE CDN C 308 source : BC1 115) chain D residue 30 type sequence I description BINDING SITE FOR RESIDUE CDN C 308 source : BC1 116) chain D residue 37 type sequence F description BINDING SITE FOR RESIDUE CDN C 308 source : BC1 117) chain D residue 41 type sequence G description BINDING SITE FOR RESIDUE CDN C 308 source : BC1 118) chain D residue 43 type sequence L description BINDING SITE FOR RESIDUE CDN C 308 source : BC1 119) chain D residue 48 type sequence W description BINDING SITE FOR RESIDUE CDN C 308 source : BC1 120) chain D residue 68 type sequence I description BINDING SITE FOR RESIDUE CDN C 308 source : BC1 121) chain C residue 107 type sequence K description BINDING SITE FOR RESIDUE EPH C 309 source : BC2 122) chain C residue 111 type sequence K description BINDING SITE FOR RESIDUE EPH C 309 source : BC2 123) chain C residue 129 type sequence W description BINDING SITE FOR RESIDUE EPH C 309 source : BC2 124) chain D residue 81-90 type TOPO_DOM sequence TDYVKPLALR description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 125) chain B residue 75 type TOPO_DOM sequence C description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 126) chain B residue 216 type TOPO_DOM sequence C description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 127) chain B residue 149 type TOPO_DOM sequence C description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 128) chain B residue 152 type TOPO_DOM sequence C description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 129) chain B residue 155 type TOPO_DOM sequence C description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 130) chain B residue 159 type TOPO_DOM sequence C description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 131) chain B residue 206 type TOPO_DOM sequence C description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 132) chain B residue 212 type TOPO_DOM sequence C description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 133) chain D residue 37-58 type TOPO_DOM sequence FATSGELTYEVWIGFFASAFTK description Periplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 134) chain A residue 354 type TOPO_DOM sequence H description Periplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 135) chain A residue 399 type TOPO_DOM sequence R description Periplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 136) chain A residue 254 type TOPO_DOM sequence T description Periplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 137) chain D residue 83 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:12560550 source Swiss-Prot : SWS_FT_FI5 138) chain A residue 43-52 type prosite sequence RSHTVSAQGG description FRD_SDH_FAD_BINDING Fumarate reductase / succinate dehydrogenase FAD-binding site. RSHTvsAqGG source prosite : PS00504 139) chain B residue 149-160 type prosite sequence CILCACCSTSCP description 4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiLCAcCStSCP source prosite : PS00198 140) chain C residue 9-33 type prosite sequence RPVNLDLQTIRFPITAIASILHRVS description SDH_CYT_1 Succinate dehydrogenase cytochrome b subunit signature 1. RPVnldLqtirfpItaiaSilHRvS source prosite : PS01000 141) chain C residue 84-97 type prosite sequence HVVVGIRHMMMDFG description SDH_CYT_2 Succinate dehydrogenase cytochrome b subunit signature 2. HvvvGIRHMmMDfG source prosite : PS01001 142) chain D residue 16-36 type TRANSMEM sequence FILVRATAIVLTLYIIYMVGF description Helical source Swiss-Prot : SWS_FT_FI2 143) chain D residue 59-80 type TRANSMEM sequence VFTLLALFSILIHAWIGMWQVL description Helical source Swiss-Prot : SWS_FT_FI2 144) chain D residue 91-115 type TRANSMEM sequence LMLQLVIVVALVVYVIYGFVVVWGV description Helical source Swiss-Prot : SWS_FT_FI2 145) chain A residue 404 type TRANSMEM sequence S description Helical source Swiss-Prot : SWS_FT_FI2 146) chain A residue 388 type TRANSMEM sequence E description Helical source Swiss-Prot : SWS_FT_FI2 147) chain D residue 71 type BINDING sequence H description axial binding residue source Swiss-Prot : SWS_FT_FI4

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