eF-site ID 1ne7-A PDB Code 1ne7 Chain A click to enlarge Title HUMAN GLUCOSAMINE-6-PHOSPHATE DEAMINASE ISOMERASE AT 1.75 A RESOLUTION COMPLEXED WITH N-ACETYL-GLUCOSAMINE-6-PHOSPHATE AND 2-DEOXY-2-AMINO-GLUCITOL-6-PHOSPHATE Classification HYDROLASE Compound Glucosamine-6-phosphate isomerase Source (GNPI_HUMAN) Sequence A:  MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLP TGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRD HPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDA FEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVK TLAMDTILANARFFDGELTKVPTMALTVGVGTVMDAREVM ILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCD EDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKEKETEKS Q Description Functional site 1) chain A residue 125-143 type prosite sequence IKAAGGIELFVGGIGPDGH description GLC_GALNAC_ISOMERASE Glucosamine/galactosamine-6-phosphate isomerases signature. IkaaGgIeLfVgGIGpDGH source prosite : PS01161 2) chain A residue 72 type ACT_SITE sequence D description Proton acceptor; for enolization step => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 3) chain A residue 141 type ACT_SITE sequence D description For ring-opening step => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 4) chain A residue 148 type ACT_SITE sequence E description For ring-opening step => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 5) chain A residue 143 type ACT_SITE sequence H description Proton acceptor; for ring-opening step => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 6) chain A residue 64 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI4 7) chain A residue 161 type MOD_RES sequence T description Phosphothreonine => ECO:0000250|UniProtKB:O88958 source Swiss-Prot : SWS_FT_FI5

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