|
|
eF-site ID
|
1nb3-DLT |
|
PDB Code
|
1nb3 |
|
Chain
|
D, L, T |
|
click to enlarge
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Title
|
Crystal structure of stefin A in complex with cathepsin H: N-terminal residues of inhibitors can adapt to the active sites of endo-and exopeptidases |
|
Classification
|
HYDROLASE |
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Compound
|
Cathepsin H |
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Source
|
ORGANISM_COMMON: pig; ORGANISM_SCIENTIFIC: Sus scrofa; |
|
|
Sequence
|
D: |
YPPSMDWRKKGNFVSPVKNQGSCGSCWTFSTTGALESAVA
IATGKMLSLAEQQLVDCAQNFNNHGCQGGLPSQAFEYIRY
NKGIMGEDTYPYKGQDDHCKFQPDKAIAFVKDVANITMND
EEAMVEAVALYNPVSFAFEVTNDFLMYRKGIYSSTSCHKT
PDKVNHAVLAVGYGEENGIPYWIVKNSWGPQWGMNGYFLI
ERGKNMCGLAACASYPIPLV
|
| L: |
MIPGGLSEAKPATPEIQEIVDKVKPQLEEKTNETYGKLEA
VQYKTQVVAGTNYYIKVRAGDNKYMHLKVFKSLPGQNEDL
VLTGYQVDKNKDDELTGF
|
| T: |
EPQNCSAT
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
D |
| residue |
19 |
| type |
catalytic |
| sequence |
Q
|
| description |
682
|
| source |
MCSA : MCSA4
|
|
|
2)
|
chain |
D |
| residue |
25 |
| type |
catalytic |
| sequence |
C
|
| description |
682
|
| source |
MCSA : MCSA4
|
|
|
3)
|
chain |
D |
| residue |
159 |
| type |
catalytic |
| sequence |
H
|
| description |
682
|
| source |
MCSA : MCSA4
|
|
|
4)
|
chain |
L |
| residue |
6 |
| type |
MOD_RES |
| sequence |
M
|
| description |
N-acetylmethionine => ECO:0000250|UniProtKB:P01039
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
D |
| residue |
25 |
| type |
SITE |
| sequence |
C
|
| description |
Reactive site
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
6)
|
chain |
D |
| residue |
159 |
| type |
SITE |
| sequence |
H
|
| description |
Reactive site
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
D |
| residue |
175 |
| type |
SITE |
| sequence |
N
|
| description |
Reactive site
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
8)
|
chain |
L |
| residue |
9 |
| type |
SITE |
| sequence |
G
|
| description |
Reactive site
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|