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eF-site ID
|
1nb3-BJR |
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PDB Code
|
1nb3 |
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Chain
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B, J, R |
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click to enlarge
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Title
|
Crystal structure of stefin A in complex with cathepsin H: N-terminal residues of inhibitors can adapt to the active sites of endo-and exopeptidases |
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Classification
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HYDROLASE |
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Compound
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Cathepsin H |
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Source
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ORGANISM_COMMON: pig; ORGANISM_SCIENTIFIC: Sus scrofa; |
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Sequence
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B: |
YPPSMDWRKKGNFVSPVKNQGSCGSCWTFSTTGALESAVA
IATGKMLSLAEQQLVDCAQNFNNHGCQGGLPSQAFEYIRY
NKGIMGEDTYPYKGQDDHCKFQPDKAIAFVKDVANITMND
EEAMVEAVALYNPVSFAFEVTNDFLMYRKGIYSSTSCHKT
PDKVNHAVLAVGYGEENGIPYWIVKNSWGPQWGMNGYFLI
ERGKNMCGLAACASYPIPLV
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| J: |
MIPGGLSEAKPATPEIQEIVDKVKPQLEEKTNETYGKLEA
VQYKTQVVAGTNYYIKVRAGDNKYMHLKVFKSLPGQNEDL
VLTGYQVDKNKDDELTGF
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| R: |
EPQNCSAT
|
|
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Description
|
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Functional site
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|
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1)
|
chain |
J |
| residue |
6 |
| type |
MOD_RES |
| sequence |
M
|
| description |
N-acetylmethionine => ECO:0000250|UniProtKB:P01039
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| source |
Swiss-Prot : SWS_FT_FI2
|
|
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2)
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chain |
B |
| residue |
19 |
| type |
catalytic |
| sequence |
Q
|
| description |
682
|
| source |
MCSA : MCSA2
|
|
|
3)
|
chain |
B |
| residue |
25 |
| type |
catalytic |
| sequence |
C
|
| description |
682
|
| source |
MCSA : MCSA2
|
|
|
4)
|
chain |
B |
| residue |
159 |
| type |
catalytic |
| sequence |
H
|
| description |
682
|
| source |
MCSA : MCSA2
|
|
|
5)
|
chain |
J |
| residue |
9 |
| type |
SITE |
| sequence |
G
|
| description |
Reactive site
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
6)
|
chain |
B |
| residue |
159 |
| type |
SITE |
| sequence |
H
|
| description |
Reactive site
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
B |
| residue |
175 |
| type |
SITE |
| sequence |
N
|
| description |
Reactive site
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|