eF-site ID 1nb3-AIP PDB Code 1nb3 Chain A, I, P click to enlarge Title Crystal structure of stefin A in complex with cathepsin H: N-terminal residues of inhibitors can adapt to the active sites of endo-and exopeptidases Classification HYDROLASE Compound Cathepsin H Source ORGANISM_COMMON: pig; ORGANISM_SCIENTIFIC: Sus scrofa; Sequence A:  YPPSMDWRKKGNFVSPVKNQGSCGSCWTFSTTGALESAVA IATGKMLSLAEQQLVDCAQNFNNHGCQGGLPSQAFEYIRY NKGIMGEDTYPYKGQDDHCKFQPDKAIAFVKDVANITMND EEAMVEAVALYNPVSFAFEVTNDFLMYRKGIYSSTSCHKT PDKVNHAVLAVGYGEENGIPYWIVKNSWGPQWGMNGYFLI ERGKNMCGLAACASYPIPLV I:  MIPGGLSEAKPATPEIQEIVDKVKPQLEEKTNETYGKLEA VQYKTQVVAGTNYYIKVRAGDNKYMHLKVFKSLPGQNEDL VLTGYQVDKNKDDELTGF P:  EPQNCSAT Description Functional site 1) chain I residue 6 type MOD_RES sequence M description N-acetylmethionine => ECO:0000250|UniProtKB:P01039 source Swiss-Prot : SWS_FT_FI2 2) chain A residue 19 type catalytic sequence Q description 682 source MCSA : MCSA1 3) chain A residue 25 type catalytic sequence C description 682 source MCSA : MCSA1 4) chain A residue 159 type catalytic sequence H description 682 source MCSA : MCSA1 5) chain A residue 19-30 type prosite sequence QGSCGSCWTFST description THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGsCGSCWTfST source prosite : PS00139 6) chain A residue 157-167 type prosite sequence VNHAVLAVGYG description THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. VNHAVLAVGYG source prosite : PS00639 7) chain A residue 170-189 type prosite sequence YWIVKNSWGPQWGMNGYFLI description THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWIvKNSWgpqWGmnGYFlI source prosite : PS00640 8) chain I residue 52-65 type prosite sequence TQVVAGTNYYIKVR description CYSTATIN Cysteine proteases inhibitors signature. TQVVAGTNYyIKVR source prosite : PS00287 9) chain I residue 9 type SITE sequence G description Reactive site source Swiss-Prot : SWS_FT_FI1

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