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eF-site ID
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1nb3-A |
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PDB Code
|
1nb3 |
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Chain
|
A |
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click to enlarge
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Title
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Crystal structure of stefin A in complex with cathepsin H: N-terminal residues of inhibitors can adapt to the active sites of endo-and exopeptidases |
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Classification
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HYDROLASE |
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Compound
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Cathepsin H |
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Source
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ORGANISM_COMMON: pig; ORGANISM_SCIENTIFIC: Sus scrofa; |
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Sequence
|
A: |
YPPSMDWRKKGNFVSPVKNQGSCGSCWTFSTTGALESAVA
IATGKMLSLAEQQLVDCAQNFNNHGCQGGLPSQAFEYIRY
NKGIMGEDTYPYKGQDDHCKFQPDKAIAFVKDVANITMND
EEAMVEAVALYNPVSFAFEVTNDFLMYRKGIYSSTSCHKT
PDKVNHAVLAVGYGEENGIPYWIVKNSWGPQWGMNGYFLI
ERGKNMCGLAACASYPIPLV
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Description
|
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Functional site
|
|
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1)
|
chain |
A |
| residue |
19 |
| type |
catalytic |
| sequence |
Q
|
| description |
682
|
| source |
MCSA : MCSA1
|
|
|
2)
|
chain |
A |
| residue |
25 |
| type |
catalytic |
| sequence |
C
|
| description |
682
|
| source |
MCSA : MCSA1
|
|
|
3)
|
chain |
A |
| residue |
159 |
| type |
catalytic |
| sequence |
H
|
| description |
682
|
| source |
MCSA : MCSA1
|
|
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4)
|
chain |
A |
| residue |
19-30 |
| type |
prosite |
| sequence |
QGSCGSCWTFST
|
| description |
THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGsCGSCWTfST
|
| source |
prosite : PS00139
|
|
|
5)
|
chain |
A |
| residue |
157-167 |
| type |
prosite |
| sequence |
VNHAVLAVGYG
|
| description |
THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. VNHAVLAVGYG
|
| source |
prosite : PS00639
|
|
|
6)
|
chain |
A |
| residue |
170-189 |
| type |
prosite |
| sequence |
YWIVKNSWGPQWGMNGYFLI
|
| description |
THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWIvKNSWgpqWGmnGYFlI
|
| source |
prosite : PS00640
|
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