eF-site ID 1n6e-I PDB Code 1n6e Chain I Title tricorn protease in complex with a tridecapeptide chloromethyl ketone derivative Classification HYDROLASE Compound Tricorn protease Source null (1N6E) Sequence I:  MPNLLLNPDIHGDRIIFVCCDDLWEHDLKSGSTRKIVSNL GVINNARFFPDGRKIAIRVMRGSSLNTADLYFYNGENGEI KRITYFSGKSTGRRMFTDVAGFDPDGNLIISTDAMQPFSS MTCLYRVENDGINFVPLNLGPATHILFADGRRVIGRNTFE LPHWKGYRGGTRGKIWIEVNSGAFKKIVDMSTHVSSPVIV GHRIYFITDIDGFGQIYSTDLDGKDLRKHTSFTDYYPRHL NTDGRRILFSKGGSIYIFNPDTEKIEKIEIGDLESPEDRI ISIPSKFAEDFSPLDGDLIAFVSRGQAFIQDVSGTYVLKV PEPLRIRYVRRGGDTKVAFIHGTREGDFLGIYDYRTGKAE KFEENLGNVFAMGVDRNGKFAVVANDRFEIMTVDLETGKP TVIERSREAMITDFTISDNSRFIAYGFPLKHGETDGYVMQ AIHVYDMEGRKIFAATTENSHDYAPAFDADSKNLYYLSYR SLDPSPDRVVLNFSFEVVSKPFVIPLIPGSPNPTKLVPRS MTSEAGEYDLNDMYKRSSPINVDPGDYRMIIPLESSILIY SVPVHGEFAAYYQGAPEKGVLLKYDVKTRKVTEVKNNLTD LRLSADRKTVMVRKDDGKIYTFPLEKPEDERTVETDKRPL VSSIHEEFLQMYDEAWKLARDNYWNEAVAKEISERIYEKY RNLVPLCKTRYDLSNVIVEMQGEYRTSHSYEMGGTFTDKD PFRSGRIACDFKLDGDHYVVAKAYAGDYSNEGEKSPIFEY GIDPTGYLIEDIDGETVGAGSNIYRVLSEKAGTSARIRLS GKGGDKRDLMIDILDDDRFIRYRSWVEANRRYVHERSKGT IGYIHIPDMGMMGLNEFYRLFINESSYQGLIVDVRFNGGG FVSQLIIEKLMNKRIGYDNPRRGTLSPYPTNSVRGKIIAI TNEYAGSDGDIFSFSFKKLGLGKLIGTRTWGGVVGITPKR RLIDGTVLTQPEFAFWFRDAGFGVENYGVDPDVEIEYAPH DYLSGKDPQIDYAIDALIEELRN Description Functional site 1) chain I residue 746 type sequence H description BINDING SITE FOR RESIDUE 0QE J 1214 source : AC5 2) chain I residue 965 type sequence S description BINDING SITE FOR RESIDUE 0QE J 1214 source : AC5 3) chain I residue 966 type sequence D description BINDING SITE FOR RESIDUE 0QE J 1214 source : AC5 4) chain I residue 993 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI5 5) chain I residue 746 type catalytic sequence H description 808 source MCSA : MCSA5 6) chain I residue 918 type catalytic sequence G description 808 source MCSA : MCSA5 7) chain I residue 965 type catalytic sequence S description 808 source MCSA : MCSA5 8) chain I residue 966 type catalytic sequence D description 808 source MCSA : MCSA5 9) chain I residue 746 type ACT_SITE sequence H description Charge relay system => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI1 10) chain I residue 965 type ACT_SITE sequence S description Nucleophile => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI2 11) chain I residue 1023 type ACT_SITE sequence E description Charge relay system => ECO:0000269|PubMed:11719810 source Swiss-Prot : SWS_FT_FI3 12) chain I residue 916 type BINDING sequence G description BINDING => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI4 13) chain I residue 936 type SITE sequence D description Substrate specificity switch => ECO:0000269|PubMed:11719810 source Swiss-Prot : SWS_FT_FI6 14) chain I residue 966 type SITE sequence D description Transition state stabilizer; via amide nitrogen => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI7

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