eF-site ID 1n5y-B PDB Code 1n5y Chain B click to enlarge Title HIV-1 Reverse Transcriptase Crosslinked to Post-Translocation AZTMP-Terminated DNA (Complex P) Classification TRANSFERASE/IMMUNE SYSTEM/DNA Compound 5'-D(*AP*TP*GP*C*TP*AP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3' Source ORGANISM_COMMON: house mouse; ORGANISM_SCIENTIFIC: Mus musculus; Sequence B:  PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTE MEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFREL NKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIF QSSMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQHRT KIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLS KLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYD PSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWET WWTEYWQATWIPEWEFVNTPPLVKLWYQL Description Functional site 1) chain B residue 196 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 2) chain B residue 210 type SITE sequence L description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 3) chain B residue 265 type SITE sequence N description Cleavage; by viral protease => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 4) chain B residue 273 type SITE sequence G description Cleavage; by viral protease source Swiss-Prot : SWS_FT_FI7 5) chain B residue 333 type SITE sequence G description Cleavage; by viral protease source Swiss-Prot : SWS_FT_FI7 6) chain B residue 223-240 type ZN_FING sequence KEPPFLWMGYELHPDKWT description CCHC-type 1 => ECO:0000255|PROSITE-ProRule:PRU00047 source Swiss-Prot : SWS_FT_FI1 7) chain B residue 220 type MOD_RES sequence K description Asymmetric dimethylarginine; in Nucleocapsid protein p7; by host PRMT6 => ECO:0000269|PubMed:17415034 source Swiss-Prot : SWS_FT_FI8 8) chain B residue 242 type MOD_RES sequence Q description Asymmetric dimethylarginine; in Nucleocapsid protein p7; by host PRMT6 => ECO:0000269|PubMed:17415034 source Swiss-Prot : SWS_FT_FI8 9) chain B residue 244-261 type ZN_FING sequence IVLPEKDSWTVNDIQKLV description CCHC-type 2 => ECO:0000255|PROSITE-ProRule:PRU00047 source Swiss-Prot : SWS_FT_FI2 10) chain B residue 358 type ACT_SITE sequence R description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094, ECO:0000269|PubMed:12924029 source Swiss-Prot : SWS_FT_FI3 11) chain B residue 54 type SITE sequence N description Cis/trans isomerization of proline peptide bond; by human PPIA/CYPA => ECO:0000250 source Swiss-Prot : SWS_FT_FI4

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