eF-site ID 1n49-C PDB Code 1n49 Chain C click to enlarge Title Viability of a Drug-Resistant HIV-1 Protease Variant: Structural Insights for Better Anti-Viral Therapy Classification HYDROLASE/HYDROLASE INHIBITOR Compound Protease Source Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) (POL_HV1A2) Sequence C:  PQITLWKRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEICGHKAIGTVLVGPT PANIIGRNLLTQIGCTLNF Description Functional site 1) chain C residue 8 type sequence R description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 2) chain C residue 25 type sequence N description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 3) chain C residue 27 type sequence G description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 4) chain C residue 30 type sequence D description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 5) chain C residue 32 type sequence V description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 6) chain C residue 47 type sequence I description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 7) chain C residue 49 type sequence G description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 8) chain C residue 50 type sequence I description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 9) chain C residue 81 type sequence P description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 10) chain C residue 84 type sequence I description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 11) chain C residue 78 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 12) chain C residue 78 type MOD_RES sequence G description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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