eF-site ID 1n49-ABCD PDB Code 1n49 Chain A, B, C, D click to enlarge Title Viability of a Drug-Resistant HIV-1 Protease Variant: Structural Insights for Better Anti-Viral Therapy Classification HYDROLASE/HYDROLASE INHIBITOR Compound Protease Source null (POL_HV1A2) Sequence A:  PQITLWKRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEICGHKAIGTVLVGPT PANIIGRNLLTQIGCTLNF B:  PQITLWKRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEICGHKAIGTVLVGPT PANIIGRNLLTQIGCTLNF C:  PQITLWKRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEICGHKAIGTVLVGPT PANIIGRNLLTQIGCTLNF D:  PQITLWKRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEICGHKAIGTVLVGPT PANIIGRNLLTQIGCTLNF Description Functional site 1) chain A residue 25 type sequence N description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 2) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 3) chain A residue 28 type sequence A description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 4) chain A residue 29 type sequence D description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 5) chain A residue 48 type sequence G description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 6) chain A residue 49 type sequence G description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 7) chain A residue 50 type sequence I description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 8) chain A residue 81 type sequence P description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 9) chain A residue 84 type sequence I description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 10) chain B residue 8 type sequence R description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 11) chain B residue 25 type sequence N description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 12) chain B residue 27 type sequence G description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 13) chain B residue 30 type sequence D description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 14) chain B residue 32 type sequence V description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 15) chain B residue 49 type sequence G description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 16) chain B residue 81 type sequence P description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 17) chain B residue 84 type sequence I description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 18) chain C residue 8 type sequence R description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 19) chain C residue 25 type sequence N description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 20) chain C residue 27 type sequence G description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 21) chain C residue 30 type sequence D description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 22) chain C residue 32 type sequence V description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 23) chain C residue 47 type sequence I description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 24) chain C residue 49 type sequence G description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 25) chain C residue 50 type sequence I description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 26) chain C residue 81 type sequence P description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 27) chain C residue 84 type sequence I description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 28) chain D residue 25 type sequence N description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 29) chain D residue 27 type sequence G description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 30) chain D residue 28 type sequence A description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 31) chain D residue 29 type sequence D description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 32) chain D residue 48 type sequence G description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 33) chain D residue 49 type sequence G description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 34) chain D residue 50 type sequence I description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 35) chain D residue 81 type sequence P description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 36) chain D residue 84 type sequence I description BINDING SITE FOR RESIDUE RIT D 401 source : AC2 37) chain A residue 78 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 38) chain B residue 78 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 39) chain C residue 78 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 40) chain D residue 78 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 41) chain A residue 78 type MOD_RES sequence G description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 42) chain B residue 78 type MOD_RES sequence G description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 43) chain C residue 78 type MOD_RES sequence G description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 44) chain D residue 78 type MOD_RES sequence G description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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