eF-site ID 1n49-A PDB Code 1n49 Chain A click to enlarge Title Viability of a Drug-Resistant HIV-1 Protease Variant: Structural Insights for Better Anti-Viral Therapy Classification HYDROLASE/HYDROLASE INHIBITOR Compound Protease Source Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) (POL_HV1A2) Sequence A:  PQITLWKRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEICGHKAIGTVLVGPT PANIIGRNLLTQIGCTLNF Description Functional site 1) chain A residue 25 type sequence N description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 2) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 3) chain A residue 28 type sequence A description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 4) chain A residue 29 type sequence D description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 5) chain A residue 48 type sequence G description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 6) chain A residue 49 type sequence G description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 7) chain A residue 50 type sequence I description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 8) chain A residue 81 type sequence P description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 9) chain A residue 84 type sequence I description BINDING SITE FOR RESIDUE RIT B 301 source : AC1 10) chain A residue 78 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 11) chain A residue 78 type MOD_RES sequence G description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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