eF-site ID 1n31-AB PDB Code 1n31 Chain A, B click to enlarge Title Structure of A Catalytically Inactive Mutant (K223A) of C-DES with a Substrate (Cystine) Linked to the Co-Factor Classification LYASE Compound L-cysteine/cystine lyase C-DES Source (AAD02935) Sequence A:  TPDRHQFPGLANKTYFNFGGQGILPTVALEAITAMYGYLQ ENGPFSIAANQHIQQLIAQLRQALAETFNVDPNTITITDN VTTGCDIVLWGLDWHQGDEILLTDCEHPGIIAIVQAIAAR FGITYRFFPVAATLNQGDAAAVLANHLGPKTRLVILSHLL WNTGQVLPLAEIMAVCRRHQGNYPVRVLVDGAQSAGSLPL DFSRLEVDYYAFTGHAWFAGPAGVGGLYIHGDCLGEINPT YVGWRSITYGAKGEPTGWAEGGKRFEVATSAYPQYAGLLA ALQLHQRQGTAEERYQAICQRSEFLWRGLNQLPHVHCLAT SAPQAGLVSFTVDSPLGHRAIVQKLEEQRIYLRTIADPDC IRACCHYITDEEEINHLLARLADFGP B:  TPDRHQFPGLANKTYFNFGGQGILPTVALEAITAMYGYLQ ENGPFSIAANQHIQQLIAQLRQALAETFNVDPNTITITDN VTTGCDIVLWGLDWHQGDEILLTDCEHPGIIAIVQAIAAR FGITYRFFPVAATLNQGDAAAVLANHLGPKTRLVILSHLL WNTGQVLPLAEIMAVCRRHQGNYPVRVLVDGAQSAGSLPL DFSRLEVDYYAFTGHAWFAGPAGVGGLYIHGDCLGEINPT YVGWRSITYGAKGEPTGWAEGGKRFEVATSAYPQYAGLLA ALQLHQRQGTAEERYQAICQRSEFLWRGLNQLPHVHCLAT SAPQAGLVSFTVDSPLGHRAIVQKLEEQRIYLRTIADPDC IRACCHYITDEEEINHLLARLADFGP Description Functional site 1) chain A residue 316 type sequence L description BINDING SITE FOR RESIDUE K A 1001 source : AC1 2) chain A residue 317 type sequence N description BINDING SITE FOR RESIDUE K A 1001 source : AC1 3) chain A residue 319 type sequence L description BINDING SITE FOR RESIDUE K A 1001 source : AC1 4) chain A residue 322 type sequence V description BINDING SITE FOR RESIDUE K A 1001 source : AC1 5) chain B residue 316 type sequence L description BINDING SITE FOR RESIDUE K B 1002 source : AC2 6) chain B residue 317 type sequence N description BINDING SITE FOR RESIDUE K B 1002 source : AC2 7) chain B residue 319 type sequence L description BINDING SITE FOR RESIDUE K B 1002 source : AC2 8) chain B residue 322 type sequence V description BINDING SITE FOR RESIDUE K B 1002 source : AC2 9) chain A residue 87 type sequence N description BINDING SITE FOR RESIDUE PLP A 2001 source : AC3 10) chain A residue 88 type sequence V description BINDING SITE FOR RESIDUE PLP A 2001 source : AC3 11) chain A residue 89 type sequence T description BINDING SITE FOR RESIDUE PLP A 2001 source : AC3 12) chain A residue 114 type sequence H description BINDING SITE FOR RESIDUE PLP A 2001 source : AC3 13) chain A residue 164 type sequence S description BINDING SITE FOR RESIDUE PLP A 2001 source : AC3 14) chain A residue 168 type sequence W description BINDING SITE FOR RESIDUE PLP A 2001 source : AC3 15) chain A residue 197 type sequence D description BINDING SITE FOR RESIDUE PLP A 2001 source : AC3 16) chain A residue 199 type sequence A description BINDING SITE FOR RESIDUE PLP A 2001 source : AC3 17) chain A residue 200 type sequence Q description BINDING SITE FOR RESIDUE PLP A 2001 source : AC3 18) chain A residue 222 type sequence H description BINDING SITE FOR RESIDUE PLP A 2001 source : AC3 19) chain B residue 251 type sequence W description BINDING SITE FOR RESIDUE PLP A 2001 source : AC3 20) chain B residue 275 type sequence A description BINDING SITE FOR RESIDUE PLP A 2001 source : AC3 21) chain B residue 276 type sequence T description BINDING SITE FOR RESIDUE PLP A 2001 source : AC3 22) chain A residue 26 type sequence G description BINDING SITE FOR RESIDUE CYS A 2002 source : AC4 23) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE CYS A 2002 source : AC4 24) chain A residue 168 type sequence W description BINDING SITE FOR RESIDUE CYS A 2002 source : AC4 25) chain A residue 200 type sequence Q description BINDING SITE FOR RESIDUE CYS A 2002 source : AC4 26) chain A residue 360 type sequence R description BINDING SITE FOR RESIDUE CYS A 2002 source : AC4 27) chain A residue 369 type sequence R description BINDING SITE FOR RESIDUE CYS A 2002 source : AC4 28) chain A residue 114 type sequence H description BINDING SITE FOR RESIDUE CYS A 2003 source : AC5 29) chain A residue 168 type sequence W description BINDING SITE FOR RESIDUE CYS A 2003 source : AC5 30) chain A residue 360 type sequence R description BINDING SITE FOR RESIDUE CYS A 2003 source : AC5 31) chain B residue 251 type sequence W description BINDING SITE FOR RESIDUE CYS A 2003 source : AC5 32) chain A residue 251 type sequence W description BINDING SITE FOR RESIDUE PLP B 3001 source : AC6 33) chain A residue 275 type sequence A description BINDING SITE FOR RESIDUE PLP B 3001 source : AC6 34) chain A residue 276 type sequence T description BINDING SITE FOR RESIDUE PLP B 3001 source : AC6 35) chain B residue 87 type sequence N description BINDING SITE FOR RESIDUE PLP B 3001 source : AC6 36) chain B residue 88 type sequence V description BINDING SITE FOR RESIDUE PLP B 3001 source : AC6 37) chain B residue 89 type sequence T description BINDING SITE FOR RESIDUE PLP B 3001 source : AC6 38) chain B residue 114 type sequence H description BINDING SITE FOR RESIDUE PLP B 3001 source : AC6 39) chain B residue 168 type sequence W description BINDING SITE FOR RESIDUE PLP B 3001 source : AC6 40) chain B residue 197 type sequence D description BINDING SITE FOR RESIDUE PLP B 3001 source : AC6 41) chain B residue 199 type sequence A description BINDING SITE FOR RESIDUE PLP B 3001 source : AC6 42) chain B residue 200 type sequence Q description BINDING SITE FOR RESIDUE PLP B 3001 source : AC6 43) chain B residue 222 type sequence H description BINDING SITE FOR RESIDUE PLP B 3001 source : AC6 44) chain B residue 26 type sequence G description BINDING SITE FOR RESIDUE CYS B 3002 source : AC7 45) chain B residue 27 type sequence G description BINDING SITE FOR RESIDUE CYS B 3002 source : AC7 46) chain B residue 114 type sequence H description BINDING SITE FOR RESIDUE CYS B 3002 source : AC7 47) chain B residue 168 type sequence W description BINDING SITE FOR RESIDUE CYS B 3002 source : AC7 48) chain B residue 200 type sequence Q description BINDING SITE FOR RESIDUE CYS B 3002 source : AC7 49) chain B residue 360 type sequence R description BINDING SITE FOR RESIDUE CYS B 3002 source : AC7 50) chain B residue 369 type sequence R description BINDING SITE FOR RESIDUE CYS B 3002 source : AC7 51) chain A residue 52 type sequence F description BINDING SITE FOR RESIDUE CYS A 3003 source : AC8 52) chain A residue 251 type sequence W description BINDING SITE FOR RESIDUE CYS A 3003 source : AC8 53) chain B residue 360 type sequence R description BINDING SITE FOR RESIDUE CYS A 3003 source : AC8

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