|
|
eF-site ID
|
1n0j-AB |
|
PDB Code
|
1n0j |
|
Chain
|
A, B |
|
click to enlarge
|
|
|
Title
|
The Structure of Human Mitochondrial MN3+ Superoxide Dismutase Reveals a Novel Tetrameric Interface of Two 4-Helix Bundles |
|
Classification
|
OXIDOREDUCTASE |
|
Compound
|
Superoxide dismutase [Mn] |
|
Source
|
Homo sapiens (Human) (SODM_HUMAN) |
|
|
Sequence
|
A: |
KHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNV
TEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTN
LSPNGGGEPKGELLEAIKRDFGSFDKFKEKLTAASVGVQG
SGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDV
WEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK
|
| B: |
KHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNV
TEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTN
LSPNGGGEPKGELLEAIKRDFGSFDKFKEKLTAASVGVQG
SGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDV
WEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
26 |
| type |
|
| sequence |
H
|
| description |
active site, trigonal bipyramidal manganese
|
| source |
: MNA
|
|
|
2)
|
chain |
A |
| residue |
74 |
| type |
|
| sequence |
H
|
| description |
active site, trigonal bipyramidal manganese
|
| source |
: MNA
|
|
|
3)
|
chain |
A |
| residue |
159 |
| type |
|
| sequence |
D
|
| description |
active site, trigonal bipyramidal manganese
|
| source |
: MNA
|
|
|
4)
|
chain |
A |
| residue |
163 |
| type |
|
| sequence |
H
|
| description |
active site, trigonal bipyramidal manganese
|
| source |
: MNA
|
|
|
5)
|
chain |
B |
| residue |
26 |
| type |
|
| sequence |
H
|
| description |
active site, trigonal bipyramidal manganese
|
| source |
: MNB
|
|
|
6)
|
chain |
B |
| residue |
74 |
| type |
|
| sequence |
H
|
| description |
active site, trigonal bipyramidal manganese
|
| source |
: MNB
|
|
|
7)
|
chain |
B |
| residue |
159 |
| type |
|
| sequence |
D
|
| description |
active site, trigonal bipyramidal manganese
|
| source |
: MNB
|
|
|
8)
|
chain |
B |
| residue |
163 |
| type |
|
| sequence |
H
|
| description |
active site, trigonal bipyramidal manganese
|
| source |
: MNB
|
|
|
9)
|
chain |
A |
| residue |
26 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE MN A 199
|
| source |
: AC1
|
|
|
10)
|
chain |
A |
| residue |
74 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE MN A 199
|
| source |
: AC1
|
|
|
11)
|
chain |
A |
| residue |
159 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MN A 199
|
| source |
: AC1
|
|
|
12)
|
chain |
A |
| residue |
163 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE MN A 199
|
| source |
: AC1
|
|
|
13)
|
chain |
B |
| residue |
26 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE MN B 199
|
| source |
: AC2
|
|
|
14)
|
chain |
B |
| residue |
74 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE MN B 199
|
| source |
: AC2
|
|
|
15)
|
chain |
B |
| residue |
159 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MN B 199
|
| source |
: AC2
|
|
|
16)
|
chain |
B |
| residue |
163 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE MN B 199
|
| source |
: AC2
|
|
|
17)
|
chain |
A |
| residue |
159-166 |
| type |
prosite |
| sequence |
DVWEHAYY
|
| description |
SOD_MN Manganese and iron superoxide dismutases signature. DvWEHAYY
|
| source |
prosite : PS00088
|
|
|
18)
|
chain |
A |
| residue |
26 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:10852710, ECO:0000269|PubMed:11580280, ECO:0000269|PubMed:1394426, ECO:0000269|PubMed:19265433, ECO:0000269|PubMed:9537987, ECO:0000269|PubMed:9537988, ECO:0000312|PDB:1JA8, ECO:0007744|PDB:1AP5, ECO:0007744|PDB:1AP6, ECO:0007744|PDB:1EM1, ECO:0007744|PDB:1N0J, ECO:0007744|PDB:1QNM, ECO:0007744|PDB:1ZSP, ECO:0007744|PDB:1ZTE, ECO:0007744|PDB:1ZUQ, ECO:0007744|PDB:2P4K
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
19)
|
chain |
A |
| residue |
74 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:10852710, ECO:0000269|PubMed:11580280, ECO:0000269|PubMed:1394426, ECO:0000269|PubMed:19265433, ECO:0000269|PubMed:9537987, ECO:0000269|PubMed:9537988, ECO:0000312|PDB:1JA8, ECO:0007744|PDB:1AP5, ECO:0007744|PDB:1AP6, ECO:0007744|PDB:1EM1, ECO:0007744|PDB:1N0J, ECO:0007744|PDB:1QNM, ECO:0007744|PDB:1ZSP, ECO:0007744|PDB:1ZTE, ECO:0007744|PDB:1ZUQ, ECO:0007744|PDB:2P4K
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
20)
|
chain |
A |
| residue |
159 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:10852710, ECO:0000269|PubMed:11580280, ECO:0000269|PubMed:1394426, ECO:0000269|PubMed:19265433, ECO:0000269|PubMed:9537987, ECO:0000269|PubMed:9537988, ECO:0000312|PDB:1JA8, ECO:0007744|PDB:1AP5, ECO:0007744|PDB:1AP6, ECO:0007744|PDB:1EM1, ECO:0007744|PDB:1N0J, ECO:0007744|PDB:1QNM, ECO:0007744|PDB:1ZSP, ECO:0007744|PDB:1ZTE, ECO:0007744|PDB:1ZUQ, ECO:0007744|PDB:2P4K
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
21)
|
chain |
A |
| residue |
163 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:10852710, ECO:0000269|PubMed:11580280, ECO:0000269|PubMed:1394426, ECO:0000269|PubMed:19265433, ECO:0000269|PubMed:9537987, ECO:0000269|PubMed:9537988, ECO:0000312|PDB:1JA8, ECO:0007744|PDB:1AP5, ECO:0007744|PDB:1AP6, ECO:0007744|PDB:1EM1, ECO:0007744|PDB:1N0J, ECO:0007744|PDB:1QNM, ECO:0007744|PDB:1ZSP, ECO:0007744|PDB:1ZTE, ECO:0007744|PDB:1ZUQ, ECO:0007744|PDB:2P4K
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
22)
|
chain |
B |
| residue |
26 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:10852710, ECO:0000269|PubMed:11580280, ECO:0000269|PubMed:1394426, ECO:0000269|PubMed:19265433, ECO:0000269|PubMed:9537987, ECO:0000269|PubMed:9537988, ECO:0000312|PDB:1JA8, ECO:0007744|PDB:1AP5, ECO:0007744|PDB:1AP6, ECO:0007744|PDB:1EM1, ECO:0007744|PDB:1N0J, ECO:0007744|PDB:1QNM, ECO:0007744|PDB:1ZSP, ECO:0007744|PDB:1ZTE, ECO:0007744|PDB:1ZUQ, ECO:0007744|PDB:2P4K
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
23)
|
chain |
B |
| residue |
74 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:10852710, ECO:0000269|PubMed:11580280, ECO:0000269|PubMed:1394426, ECO:0000269|PubMed:19265433, ECO:0000269|PubMed:9537987, ECO:0000269|PubMed:9537988, ECO:0000312|PDB:1JA8, ECO:0007744|PDB:1AP5, ECO:0007744|PDB:1AP6, ECO:0007744|PDB:1EM1, ECO:0007744|PDB:1N0J, ECO:0007744|PDB:1QNM, ECO:0007744|PDB:1ZSP, ECO:0007744|PDB:1ZTE, ECO:0007744|PDB:1ZUQ, ECO:0007744|PDB:2P4K
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
24)
|
chain |
B |
| residue |
159 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:10852710, ECO:0000269|PubMed:11580280, ECO:0000269|PubMed:1394426, ECO:0000269|PubMed:19265433, ECO:0000269|PubMed:9537987, ECO:0000269|PubMed:9537988, ECO:0000312|PDB:1JA8, ECO:0007744|PDB:1AP5, ECO:0007744|PDB:1AP6, ECO:0007744|PDB:1EM1, ECO:0007744|PDB:1N0J, ECO:0007744|PDB:1QNM, ECO:0007744|PDB:1ZSP, ECO:0007744|PDB:1ZTE, ECO:0007744|PDB:1ZUQ, ECO:0007744|PDB:2P4K
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
25)
|
chain |
B |
| residue |
163 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:10852710, ECO:0000269|PubMed:11580280, ECO:0000269|PubMed:1394426, ECO:0000269|PubMed:19265433, ECO:0000269|PubMed:9537987, ECO:0000269|PubMed:9537988, ECO:0000312|PDB:1JA8, ECO:0007744|PDB:1AP5, ECO:0007744|PDB:1AP6, ECO:0007744|PDB:1EM1, ECO:0007744|PDB:1N0J, ECO:0007744|PDB:1QNM, ECO:0007744|PDB:1ZSP, ECO:0007744|PDB:1ZTE, ECO:0007744|PDB:1ZUQ, ECO:0007744|PDB:2P4K
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
26)
|
chain |
A |
| residue |
34 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
3'-nitrotyrosine => ECO:0000269|PubMed:10334867, ECO:0000269|PubMed:16399855
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
27)
|
chain |
B |
| residue |
34 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
3'-nitrotyrosine => ECO:0000269|PubMed:10334867, ECO:0000269|PubMed:16399855
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
28)
|
chain |
A |
| residue |
44 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P09671
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
29)
|
chain |
A |
| residue |
51 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P09671
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
30)
|
chain |
A |
| residue |
98 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P09671
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
31)
|
chain |
A |
| residue |
106 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P09671
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
32)
|
chain |
B |
| residue |
44 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P09671
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
33)
|
chain |
B |
| residue |
51 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P09671
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
34)
|
chain |
B |
| residue |
98 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P09671
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
35)
|
chain |
B |
| residue |
106 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P09671
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
36)
|
chain |
A |
| residue |
90 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine => ECO:0000250|UniProtKB:P09671
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
37)
|
chain |
A |
| residue |
178 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine => ECO:0000250|UniProtKB:P09671
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
38)
|
chain |
B |
| residue |
90 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine => ECO:0000250|UniProtKB:P09671
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
39)
|
chain |
B |
| residue |
178 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine => ECO:0000250|UniProtKB:P09671
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
|