eF-site ID 1n0h-AB PDB Code 1n0h Chain A, B click to enlarge Title Crystal Structure of Yeast Acetohydroxyacid Synthase in Complex with a Sulfonylurea Herbicide, Chlorimuron Ethyl Classification LYASE Compound Acetolactate synthase Source null (ILVB_YEAST) Sequence A:  PDMDTSFVGLTGGQIFNEMMSRQNVDTVFGYPGGAILPVY DAIHNSDKFNFVLPKHEQGAGHMAEGYARASGKPGVVLVT SGPGATNVVTPMADAFADGIPMVVFTGQVPTSAIGTDAFQ EADVVGISRSCTKWNVMVKSVEELPLRINEAFEIATSGRP GPVLVDLPKDVTAAILRNPIPTKTTLPSTSRAQDEFVMQS INKAADLINLAKKPVLYVGAGILNHADGPRLLKELSDRAQ IPVTTTLQGLGSFDQEDPKSLDMLGMHGCATANLAVQNAD LIIAVGARFDDRVTGNISKFAPEARRAAAEGRGGIIHFEV SPKNINKVVQTQIAVEGDATTNLGKMMSKIFPVKERSEWF AQINKWKKEYPYAYMEETPGSKIKPQTVIKKLSKVANDTG RHVIVTTGVGQHQMWAAQHWTWRNPHTFITSGGLGTMGYG LPAAIGAQVAKPESLVIDIDGDASFNMTLTELSSAVQAGT PVKILILNNEEQGMVTQWQSLFYEHRYSHTHQLNPDFIKL AEAMGLKGLRVKKQEELDAKLKEFVSTKGPVLLEVEVDKK VPVLPMVAGGSGLDEFINFDPEVERQQTELRHKRTGGKH B:  PDMDTSFVGLTGGQIFNEMMSRQNVDTVFGYPGGAILPVY DAIHNSDKFNFVLPKHEQGAGHMAEGYARASGKPGVVLVT SGPGATNVVTPMADAFADGIPMVVFTGQVPTSAIGTDAFQ EADVVGISRSCTKWNVMVKSVEELPLRINEAFEIATSGRP GPVLVDLPKDVTAAILRNPIPTKTTLPSSRAQDEFVMQSI NKAADLINLAKKPVLYVGAGILNHADGPRLLKELSDRAQI PVTTTLQGLGSFDQEDPKSLDMLGMHGCATANLAVQNADL IIAVGARFDDRVTGNISKFAPEARRAAAEGRGGIIHFEVS PKNINKVVQTQIAVEGDATTNLGKMMSKIFPVKERSEWFA QINKWKKEYPYAYMEETPGSKIKPQTVIKKLSKVANDTGR HVIVTTGVGQHQMWAAQHWTWRNPHTFITSGGLGTMGYGL PAAIGAQVAKPESLVIDIDGDASFNMTLTELSSAVQAGTP VKILILNNEEQGMVTQWQSLFYEHRYSHTHQLNPDFIKLA EAMGLKGLRVKKQEELDAKLKEFVSTKGPVLLEVEVDKKV PVLPMVAGGSGLDEFINFDPEVERQQTELRHKRTGGKH Description (1)  Acetolactate synthase (E.C.4.1.3.18) Functional site 1) chain A residue 343 type sequence Q description BINDING SITE FOR RESIDUE K A 696 source : AC1 2) chain A residue 350 type sequence D description BINDING SITE FOR RESIDUE K A 696 source : AC1 3) chain A residue 506 type sequence Q description BINDING SITE FOR RESIDUE K A 696 source : AC1 4) chain A residue 508 type sequence W description BINDING SITE FOR RESIDUE K A 696 source : AC1 5) chain A residue 550 type sequence D description BINDING SITE FOR RESIDUE MG A 699 source : AC2 6) chain A residue 577 type sequence N description BINDING SITE FOR RESIDUE MG A 699 source : AC2 7) chain A residue 579 type sequence E description BINDING SITE FOR RESIDUE MG A 699 source : AC2 8) chain B residue 343 type sequence Q description BINDING SITE FOR RESIDUE K B 1696 source : AC3 9) chain B residue 350 type sequence D description BINDING SITE FOR RESIDUE K B 1696 source : AC3 10) chain B residue 506 type sequence Q description BINDING SITE FOR RESIDUE K B 1696 source : AC3 11) chain B residue 508 type sequence W description BINDING SITE FOR RESIDUE K B 1696 source : AC3 12) chain B residue 550 type sequence D description BINDING SITE FOR RESIDUE MG B 1699 source : AC4 13) chain B residue 577 type sequence N description BINDING SITE FOR RESIDUE MG B 1699 source : AC4 14) chain B residue 579 type sequence E description BINDING SITE FOR RESIDUE MG B 1699 source : AC4 15) chain A residue 354 type sequence M description BINDING SITE FOR RESIDUE CIE A 695 source : AC5 16) chain A residue 379 type sequence D description BINDING SITE FOR RESIDUE CIE A 695 source : AC5 17) chain A residue 380 type sequence R description BINDING SITE FOR RESIDUE CIE A 695 source : AC5 18) chain A residue 583 type sequence V description BINDING SITE FOR RESIDUE CIE A 695 source : AC5 19) chain A residue 586 type sequence W description BINDING SITE FOR RESIDUE CIE A 695 source : AC5 20) chain B residue 116 type sequence G description BINDING SITE FOR RESIDUE CIE A 695 source : AC5 21) chain B residue 117 type sequence A description BINDING SITE FOR RESIDUE CIE A 695 source : AC5 22) chain B residue 191 type sequence V description BINDING SITE FOR RESIDUE CIE A 695 source : AC5 23) chain B residue 192 type sequence P description BINDING SITE FOR RESIDUE CIE A 695 source : AC5 24) chain B residue 201 type sequence F description BINDING SITE FOR RESIDUE CIE A 695 source : AC5 25) chain B residue 202 type sequence Q description BINDING SITE FOR RESIDUE CIE A 695 source : AC5 26) chain B residue 251 type sequence K description BINDING SITE FOR RESIDUE CIE A 695 source : AC5 27) chain A residue 357 type sequence C description BINDING SITE FOR RESIDUE DTT A 698 source : AC6 28) chain A residue 359 type sequence T description BINDING SITE FOR RESIDUE DTT A 698 source : AC6 29) chain A residue 455 type sequence K description BINDING SITE FOR RESIDUE DTT A 698 source : AC6 30) chain A residue 458 type sequence Y description BINDING SITE FOR RESIDUE DTT A 698 source : AC6 31) chain A residue 460 type sequence Y description BINDING SITE FOR RESIDUE DTT A 698 source : AC6 32) chain A residue 497 type sequence V description BINDING SITE FOR RESIDUE AYD A 700 source : AC7 33) chain A residue 498 type sequence G description BINDING SITE FOR RESIDUE AYD A 700 source : AC7 34) chain A residue 499 type sequence Q description BINDING SITE FOR RESIDUE AYD A 700 source : AC7 35) chain A residue 500 type sequence H description BINDING SITE FOR RESIDUE AYD A 700 source : AC7 36) chain A residue 523 type sequence G description BINDING SITE FOR RESIDUE AYD A 700 source : AC7 37) chain A residue 525 type sequence M description BINDING SITE FOR RESIDUE AYD A 700 source : AC7 38) chain A residue 549 type sequence G description BINDING SITE FOR RESIDUE AYD A 700 source : AC7 39) chain A residue 550 type sequence D description BINDING SITE FOR RESIDUE AYD A 700 source : AC7 40) chain A residue 551 type sequence A description BINDING SITE FOR RESIDUE AYD A 700 source : AC7 41) chain A residue 552 type sequence S description BINDING SITE FOR RESIDUE AYD A 700 source : AC7 42) chain A residue 555 type sequence M description BINDING SITE FOR RESIDUE AYD A 700 source : AC7 43) chain A residue 577 type sequence N description BINDING SITE FOR RESIDUE AYD A 700 source : AC7 44) chain A residue 579 type sequence E description BINDING SITE FOR RESIDUE AYD A 700 source : AC7 45) chain A residue 580 type sequence Q description BINDING SITE FOR RESIDUE AYD A 700 source : AC7 46) chain A residue 581 type sequence G description BINDING SITE FOR RESIDUE AYD A 700 source : AC7 47) chain A residue 582 type sequence M description BINDING SITE FOR RESIDUE AYD A 700 source : AC7 48) chain A residue 583 type sequence V description BINDING SITE FOR RESIDUE AYD A 700 source : AC7 49) chain B residue 114 type sequence P description BINDING SITE FOR RESIDUE AYD A 700 source : AC7 50) chain B residue 139 type sequence E description BINDING SITE FOR RESIDUE AYD A 700 source : AC7 51) chain B residue 165 type sequence P description BINDING SITE FOR RESIDUE AYD A 700 source : AC7 52) chain B residue 169 type sequence N description BINDING SITE FOR RESIDUE AYD A 700 source : AC7 53) chain B residue 202 type sequence Q description BINDING SITE FOR RESIDUE AYD A 700 source : AC7 54) chain A residue 180 type sequence D description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 55) chain A residue 241 type sequence R description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 56) chain A residue 307 type sequence G description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 57) chain A residue 308 type sequence A description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 58) chain A residue 309 type sequence G description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 59) chain A residue 312 type sequence N description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 60) chain A residue 334 type sequence T description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 61) chain A residue 335 type sequence L description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 62) chain A residue 352 type sequence L description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 63) chain A residue 353 type sequence G description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 64) chain A residue 354 type sequence M description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 65) chain A residue 355 type sequence H description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 66) chain A residue 374 type sequence G description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 67) chain A residue 375 type sequence A description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 68) chain A residue 376 type sequence R description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 69) chain A residue 378 type sequence D description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 70) chain A residue 380 type sequence R description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 71) chain A residue 381 type sequence V description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 72) chain A residue 406 type sequence F description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 73) chain A residue 407 type sequence E description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 74) chain A residue 408 type sequence V description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 75) chain A residue 412 type sequence N description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 76) chain A residue 425 type sequence G description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 77) chain A residue 426 type sequence D description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 78) chain A residue 427 type sequence A description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 79) chain A residue 501 type sequence Q description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 80) chain A residue 502 type sequence M description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 81) chain A residue 520 type sequence G description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 82) chain A residue 521 type sequence G description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 83) chain A residue 582 type sequence M description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 84) chain B residue 201 type sequence F description BINDING SITE FOR RESIDUE FAD A 701 source : AC8 85) chain A residue 116 type sequence G description BINDING SITE FOR RESIDUE CIE B 1695 source : AC9 86) chain A residue 117 type sequence A description BINDING SITE FOR RESIDUE CIE B 1695 source : AC9 87) chain A residue 191 type sequence V description BINDING SITE FOR RESIDUE CIE B 1695 source : AC9 88) chain A residue 192 type sequence P description BINDING SITE FOR RESIDUE CIE B 1695 source : AC9 89) chain A residue 201 type sequence F description BINDING SITE FOR RESIDUE CIE B 1695 source : AC9 90) chain A residue 202 type sequence Q description BINDING SITE FOR RESIDUE CIE B 1695 source : AC9 91) chain A residue 251 type sequence K description BINDING SITE FOR RESIDUE CIE B 1695 source : AC9 92) chain B residue 354 type sequence M description BINDING SITE FOR RESIDUE CIE B 1695 source : AC9 93) chain B residue 379 type sequence D description BINDING SITE FOR RESIDUE CIE B 1695 source : AC9 94) chain B residue 380 type sequence R description BINDING SITE FOR RESIDUE CIE B 1695 source : AC9 95) chain B residue 582 type sequence M description BINDING SITE FOR RESIDUE CIE B 1695 source : AC9 96) chain B residue 586 type sequence W description BINDING SITE FOR RESIDUE CIE B 1695 source : AC9 97) chain B residue 350 type sequence D description BINDING SITE FOR RESIDUE DTT B 1698 source : BC1 98) chain B residue 357 type sequence C description BINDING SITE FOR RESIDUE DTT B 1698 source : BC1 99) chain B residue 359 type sequence T description BINDING SITE FOR RESIDUE DTT B 1698 source : BC1 100) chain B residue 455 type sequence K description BINDING SITE FOR RESIDUE DTT B 1698 source : BC1 101) chain B residue 458 type sequence Y description BINDING SITE FOR RESIDUE DTT B 1698 source : BC1 102) chain B residue 459 type sequence P description BINDING SITE FOR RESIDUE DTT B 1698 source : BC1 103) chain A residue 113 type sequence Y description BINDING SITE FOR RESIDUE TPP B 1702 source : BC2 104) chain A residue 114 type sequence P description BINDING SITE FOR RESIDUE TPP B 1702 source : BC2 105) chain A residue 139 type sequence E description BINDING SITE FOR RESIDUE TPP B 1702 source : BC2 106) chain A residue 165 type sequence P description BINDING SITE FOR RESIDUE TPP B 1702 source : BC2 107) chain A residue 169 type sequence N description BINDING SITE FOR RESIDUE TPP B 1702 source : BC2 108) chain A residue 202 type sequence Q description BINDING SITE FOR RESIDUE TPP B 1702 source : BC2 109) chain B residue 497 type sequence V description BINDING SITE FOR RESIDUE TPP B 1702 source : BC2 110) chain B residue 498 type sequence G description BINDING SITE FOR RESIDUE TPP B 1702 source : BC2 111) chain B residue 499 type sequence Q description BINDING SITE FOR RESIDUE TPP B 1702 source : BC2 112) chain B residue 500 type sequence H description BINDING SITE FOR RESIDUE TPP B 1702 source : BC2 113) chain B residue 523 type sequence G description BINDING SITE FOR RESIDUE TPP B 1702 source : BC2 114) chain B residue 525 type sequence M description BINDING SITE FOR RESIDUE TPP B 1702 source : BC2 115) chain B residue 549 type sequence G description BINDING SITE FOR RESIDUE TPP B 1702 source : BC2 116) chain B residue 550 type sequence D description BINDING SITE FOR RESIDUE TPP B 1702 source : BC2 117) chain B residue 551 type sequence A description BINDING SITE FOR RESIDUE TPP B 1702 source : BC2 118) chain B residue 552 type sequence S description BINDING SITE FOR RESIDUE TPP B 1702 source : BC2 119) chain B residue 555 type sequence M description BINDING SITE FOR RESIDUE TPP B 1702 source : BC2 120) chain B residue 577 type sequence N description BINDING SITE FOR RESIDUE TPP B 1702 source : BC2 121) chain B residue 579 type sequence E description BINDING SITE FOR RESIDUE TPP B 1702 source : BC2 122) chain B residue 580 type sequence Q description BINDING SITE FOR RESIDUE TPP B 1702 source : BC2 123) chain B residue 581 type sequence G description BINDING SITE FOR RESIDUE TPP B 1702 source : BC2 124) chain B residue 582 type sequence M description BINDING SITE FOR RESIDUE TPP B 1702 source : BC2 125) chain B residue 583 type sequence V description BINDING SITE FOR RESIDUE TPP B 1702 source : BC2 126) chain A residue 201 type sequence F description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 127) chain B residue 180 type sequence D description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 128) chain B residue 241 type sequence R description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 129) chain B residue 307 type sequence G description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 130) chain B residue 308 type sequence A description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 131) chain B residue 309 type sequence G description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 132) chain B residue 312 type sequence N description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 133) chain B residue 334 type sequence T description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 134) chain B residue 335 type sequence L description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 135) chain B residue 352 type sequence L description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 136) chain B residue 353 type sequence G description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 137) chain B residue 354 type sequence M description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 138) chain B residue 355 type sequence H description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 139) chain B residue 374 type sequence G description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 140) chain B residue 375 type sequence A description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 141) chain B residue 376 type sequence R description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 142) chain B residue 378 type sequence D description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 143) chain B residue 380 type sequence R description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 144) chain B residue 381 type sequence V description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 145) chain B residue 407 type sequence E description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 146) chain B residue 408 type sequence V description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 147) chain B residue 412 type sequence N description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 148) chain B residue 425 type sequence G description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 149) chain B residue 426 type sequence D description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 150) chain B residue 427 type sequence A description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 151) chain B residue 501 type sequence Q description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 152) chain B residue 502 type sequence M description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 153) chain B residue 520 type sequence G description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 154) chain B residue 521 type sequence G description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 155) chain B residue 582 type sequence M description BINDING SITE FOR RESIDUE FAD B 1701 source : BC3 156) chain A residue 139 type catalytic sequence E description 289 source MCSA : MCSA1 157) chain A residue 201 type catalytic sequence F description 289 source MCSA : MCSA1 158) chain A residue 202 type catalytic sequence Q description 289 source MCSA : MCSA1 159) chain A residue 251 type catalytic sequence K description 289 source MCSA : MCSA1 160) chain A residue 582 type catalytic sequence M description 289 source MCSA : MCSA1 161) chain B residue 139 type catalytic sequence E description 289 source MCSA : MCSA2 162) chain B residue 201 type catalytic sequence F description 289 source MCSA : MCSA2 163) chain B residue 202 type catalytic sequence Q description 289 source MCSA : MCSA2 164) chain B residue 251 type catalytic sequence K description 289 source MCSA : MCSA2 165) chain B residue 582 type catalytic sequence M description 289 source MCSA : MCSA2 166) chain A residue 139 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI1 167) chain A residue 550 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 168) chain A residue 577 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI1 169) chain B residue 139 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI1 170) chain B residue 550 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 171) chain B residue 577 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI1 172) chain B residue 579 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI1 173) chain A residue 579 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI1 174) chain A residue 533-552 type prosite sequence IGAQVAKPESLVIDIDGDAS description TPP_ENZYMES Thiamine pyrophosphate enzymes signature. IGaqvakPeslvIdIdGDAS source prosite : PS00187 175) chain A residue 241 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12496246 source Swiss-Prot : SWS_FT_FI2 176) chain A residue 355 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12496246 source Swiss-Prot : SWS_FT_FI2 177) chain A residue 407 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12496246 source Swiss-Prot : SWS_FT_FI2 178) chain B residue 355 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12496246 source Swiss-Prot : SWS_FT_FI2 179) chain B residue 407 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12496246 source Swiss-Prot : SWS_FT_FI2 180) chain B residue 241 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12496246 source Swiss-Prot : SWS_FT_FI2

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