eF-site ID 1mv8-ABCD PDB Code 1mv8 Chain A, B, C, D click to enlarge Title 1.55 A crystal structure of a ternary complex of GDP-mannose dehydrogenase from Psuedomonas aeruginosa Classification OXIDOREDUCTASE Compound GDP-mannose 6-dehydrogenase Source Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (ALGD_PSEAE) Sequence A:  MRISIFGLGYVGAVCAGCLSARGHEVIGVDVSSTKIDLIN QGKSPIVEPGLEALLQQGRQTGRLSGTTDFKKAVLDSDVS FICVGTPSKKNGDLDLGYIETVCREIGFAIREKSERHTVV VRSTVLPGTVNNVVIPLIEDCSGKKAGVDFGVGTNPEFLR ESTAIKDYDFPPMTVIGELDKQTGDLLEEIYRELDAPIIR KTVEVAEMIKYTCNVWHAAKVTFANEIGNIAKAVGVDGRE VMDVICQDHKLNLSRYYMRPGFAFGGSCLPKDVRALTYRA SQLDVEHPMLGSLMRSNSNQVQKAFDLITSHDTRKVGLLG LSFKAGTDDLRESPLVELAEMLIGKGYELRIFDRNVEYAR VHGANKEYIESKIPHVSSLLVSDLDEVVASSDVLVLGNGD ELFVDLVNKTPSGKKLVDLVGFMPHTTTAQAEGICW B:  MRISIFGLGYVGAVCAGCLSARGHEVIGVDVSSTKIDLIN QGKSPIVEPGLEALLQQGRQTGRLSGTTDFKKAVLDSDVS FICVGTPSKKNGDLDLGYIETVCREIGFAIREKSERHTVV VRSTVLPGTVNNVVIPLIEDCSGKKAGVDFGVGTNPEFLR ESTAIKDYDFPPMTVIGELDKQTGDLLEEIYRELDAPIIR KTVEVAEMIKYTCNVWHAAKVTFANEIGNIAKAVGVDGRE VMDVICQDHKLNLSRYYMRPGFAFGGSCLPKDVRALTYRA SQLDVEHPMLGSLMRSNSNQVQKAFDLITSHDTRKVGLLG LSFKAGTDDLRESPLVELAEMLIGKGYELRIFDRNVEYAR VHGANKEYIESKIPHVSSLLVSDLDEVVASSDVLVLGNGD ELFVDLVNKTPSGKKLVDLVGFMPHTTTAQAEGICW C:  MRISIFGLGYVGAVCAGCLSARGHEVIGVDVSSTKIDLIN QGKSPIVEPGLEALLQQGRQTGRLSGTTDFKKAVLDSDVS FICVGTPSKKNGDLDLGYIETVCREIGFAIREKSERHTVV VRSTVLPGTVNNVVIPLIEDCSGKKAGVDFGVGTNPEFLR ESTAIKDYDFPPMTVIGELDKQTGDLLEEIYRELDAPIIR KTVEVAEMIKYTCNVWHAAKVTFANEIGNIAKAVGVDGRE VMDVICQDHKLNLSRYYMRPGFAFGGSCLPKDVRALTYRA SQLDVEHPMLGSLMRSNSNQVQKAFDLITSHDTRKVGLLG LSFKAGTDDLRESPLVELAEMLIGKGYELRIFDRNVEYAR VHGANKEYIESKIPHVSSLLVSDLDEVVASSDVLVLGNGD ELFVDLVNKTPSGKKLVDLVGFMPHTTTAQAEGICW D:  MRISIFGLGYVGAVCAGCLSARGHEVIGVDVSSTKIDLIN QGKSPIVEPGLEALLQQGRQTGRLSGTTDFKKAVLDSDVS FICVGTPSKKNGDLDLGYIETVCREIGFAIREKSERHTVV VRSTVLPGTVNNVVIPLIEDCSGKKAGVDFGVGTNPEFLR ESTAIKDYDFPPMTVIGELDKQTGDLLEEIYRELDAPIIR KTVEVAEMIKYTCNVWHAAKVTFANEIGNIAKAVGVDGRE VMDVICQDHKLNLSRYYMRPGFAFGGSCLPKDVRALTYRA SQLDVEHPMLGSLMRSNSNQVQKAFDLITSHDTRKVGLLG LSFKAGTDDLRESPLVELAEMLIGKGYELRIFDRNVEYAR VHGANKEYIESKIPHVSSLLVSDLDEVVASSDVLVLGNGD ELFVDLVNKTPSGKKLVDLVGFMPHTTTAQAEGICW Description Functional site 1) chain A residue 211-217 type prosite sequence YTCNVWH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCNVWH source prosite : PS00290 2) chain A residue 268 type ACT_SITE sequence C description Nucleophile => ECO:0000305|PubMed:12705829 source Swiss-Prot : SWS_FT_FI1 3) chain B residue 268 type ACT_SITE sequence C description Nucleophile => ECO:0000305|PubMed:12705829 source Swiss-Prot : SWS_FT_FI1 4) chain C residue 268 type ACT_SITE sequence C description Nucleophile => ECO:0000305|PubMed:12705829 source Swiss-Prot : SWS_FT_FI1 5) chain D residue 268 type ACT_SITE sequence C description Nucleophile => ECO:0000305|PubMed:12705829 source Swiss-Prot : SWS_FT_FI1 6) chain A residue 10 type BINDING sequence Y description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 7) chain B residue 35 type BINDING sequence K description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 8) chain B residue 86 type BINDING sequence T description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 9) chain B residue 124 type BINDING sequence T description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 10) chain C residue 10 type BINDING sequence Y description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 11) chain C residue 11 type BINDING sequence V description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 12) chain C residue 30 type BINDING sequence D description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 13) chain C residue 35 type BINDING sequence K description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 14) chain C residue 86 type BINDING sequence T description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 15) chain C residue 124 type BINDING sequence T description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 16) chain D residue 10 type BINDING sequence Y description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 17) chain A residue 11 type BINDING sequence V description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 18) chain D residue 11 type BINDING sequence V description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 19) chain D residue 30 type BINDING sequence D description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 20) chain D residue 35 type BINDING sequence K description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 21) chain D residue 86 type BINDING sequence T description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 22) chain D residue 124 type BINDING sequence T description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 23) chain A residue 30 type BINDING sequence D description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 24) chain A residue 35 type BINDING sequence K description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 86 type BINDING sequence T description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 124 type BINDING sequence T description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 27) chain B residue 10 type BINDING sequence Y description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 28) chain B residue 11 type BINDING sequence V description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 29) chain B residue 30 type BINDING sequence D description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI2 30) chain A residue 161 type BINDING sequence E description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI3 31) chain B residue 225 type BINDING sequence N description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI3 32) chain C residue 161 type BINDING sequence E description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI3 33) chain C residue 210 type BINDING sequence K description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI3 34) chain C residue 214 type BINDING sequence N description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI3 35) chain C residue 217 type BINDING sequence H description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI3 36) chain C residue 225 type BINDING sequence N description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI3 37) chain D residue 161 type BINDING sequence E description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI3 38) chain D residue 210 type BINDING sequence K description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI3 39) chain D residue 214 type BINDING sequence N description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI3 40) chain D residue 217 type BINDING sequence H description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI3 41) chain A residue 210 type BINDING sequence K description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI3 42) chain D residue 225 type BINDING sequence N description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI3 43) chain A residue 214 type BINDING sequence N description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI3 44) chain A residue 217 type BINDING sequence H description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI3 45) chain A residue 225 type BINDING sequence N description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI3 46) chain B residue 161 type BINDING sequence E description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI3 47) chain B residue 210 type BINDING sequence K description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI3 48) chain B residue 214 type BINDING sequence N description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI3 49) chain B residue 217 type BINDING sequence H description in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI3 50) chain A residue 256 type BINDING sequence Y description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 51) chain B residue 262 type BINDING sequence F description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 52) chain B residue 265 type BINDING sequence G description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 53) chain B residue 324 type BINDING sequence K description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 54) chain C residue 256 type BINDING sequence Y description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 55) chain C residue 257 type BINDING sequence Y description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 56) chain C residue 259 type BINDING sequence R description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 57) chain C residue 262 type BINDING sequence F description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 58) chain C residue 265 type BINDING sequence G description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 59) chain C residue 324 type BINDING sequence K description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 60) chain D residue 256 type BINDING sequence Y description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 61) chain A residue 257 type BINDING sequence Y description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 62) chain D residue 257 type BINDING sequence Y description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 63) chain D residue 259 type BINDING sequence R description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 64) chain D residue 262 type BINDING sequence F description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 65) chain D residue 265 type BINDING sequence G description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 66) chain D residue 324 type BINDING sequence K description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 67) chain A residue 259 type BINDING sequence R description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 68) chain A residue 262 type BINDING sequence F description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 69) chain A residue 265 type BINDING sequence G description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 70) chain A residue 324 type BINDING sequence K description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 71) chain B residue 256 type BINDING sequence Y description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 72) chain B residue 257 type BINDING sequence Y description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 73) chain B residue 259 type BINDING sequence R description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU source Swiss-Prot : SWS_FT_FI4 74) chain A residue 271 type BINDING sequence K description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI5 75) chain A residue 331 type BINDING sequence R description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI5 76) chain B residue 271 type BINDING sequence K description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI5 77) chain B residue 331 type BINDING sequence R description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI5 78) chain C residue 271 type BINDING sequence K description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI5 79) chain C residue 331 type BINDING sequence R description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI5 80) chain D residue 271 type BINDING sequence K description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI5 81) chain D residue 331 type BINDING sequence R description in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8 source Swiss-Prot : SWS_FT_FI5

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