eF-site ID 1muo-A PDB Code 1muo Chain A click to enlarge Title CRYSTAL STRUCTURE OF AURORA-2, AN ONCOGENIC SERINE-THREONINE KINASE Classification TRANSFERASE Compound Aurora-related kinase 1 Source ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: Homo sapiens; Sequence A:  WALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA QLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVY LILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYC HSKRVIHRDIKPENLLLGSAGELKIADFGWSLCGTLDYLP PEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQET YKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREV LEHPWITANSS Description Functional site 1) chain A residue 139 type sequence L description BINDING SITE FOR RESIDUE ADN A 1 source : AC1 2) chain A residue 140 type sequence G description BINDING SITE FOR RESIDUE ADN A 1 source : AC1 3) chain A residue 141 type sequence K description BINDING SITE FOR RESIDUE ADN A 1 source : AC1 4) chain A residue 194 type sequence L description BINDING SITE FOR RESIDUE ADN A 1 source : AC1 5) chain A residue 211 type sequence E description BINDING SITE FOR RESIDUE ADN A 1 source : AC1 6) chain A residue 213 type sequence A description BINDING SITE FOR RESIDUE ADN A 1 source : AC1 7) chain A residue 277 type sequence W description BINDING SITE FOR RESIDUE ADN A 1 source : AC1 8) chain A residue 256 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027, ECO:0000269|PubMed:14580337 source Swiss-Prot : SWS_FT_FI1 9) chain A residue 162 type BINDING sequence K description BINDING => ECO:0000269|PubMed:27837025, ECO:0007744|PDB:5G1X source Swiss-Prot : SWS_FT_FI2 10) chain A residue 211 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27837025, ECO:0007744|PDB:5G1X source Swiss-Prot : SWS_FT_FI2 11) chain A residue 260 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27837025, ECO:0007744|PDB:5G1X source Swiss-Prot : SWS_FT_FI2 12) chain A residue 274 type BINDING sequence D description BINDING => ECO:0000269|PubMed:27837025, ECO:0007744|PDB:5G1X source Swiss-Prot : SWS_FT_FI2 13) chain A residue 143 type BINDING sequence K description BINDING => ECO:0000269|PubMed:27837025, ECO:0007744|PDB:5G1X source Swiss-Prot : SWS_FT_FI2 14) chain A residue 342 type MOD_RES sequence S description Phosphoserine; by PKA and PAK => ECO:0000269|PubMed:16246726 source Swiss-Prot : SWS_FT_FI5 15) chain A residue 139-162 type prosite sequence LGKGKFGNVYLAREKQSKFILALK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGKFGNVYlArekqskfi..........LALK source prosite : PS00107 16) chain A residue 252-264 type prosite sequence VIHRDIKPENLLL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDIKpeNLLL source prosite : PS00108 17) chain A residue 258 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI6

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