eF-site ID 1mt8-B PDB Code 1mt8 Chain B click to enlarge Title Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy Classification HYDROLASE/HYDROLASE SUBSTRATE Compound PROTEASE RETROPEPSIN Source Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) (Q9YX54_9HIV1) Sequence B:  PQITLWKRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEICGHKAIGTVLVGPT PANIIGRNLLTQIGCTLNF Description Functional site 1) chain B residue 69 type sequence H description BINDING SITE FOR RESIDUE ACT B 501 source : AC1 2) chain B residue 70 type sequence K description BINDING SITE FOR RESIDUE ACT B 501 source : AC1 3) chain B residue 14 type sequence R description BINDING SITE FOR RESIDUE ACT B 503 source : AC2 4) chain B residue 16 type sequence G description BINDING SITE FOR RESIDUE ACT B 503 source : AC2 5) chain B residue 25 type sequence N description BINDING SITE FOR CHAIN P OF CAPSID-P2 SUBSTRATE PEPTIDE OF HIV-1 GAG POLYPROTEIN source : AC4 6) chain B residue 27 type sequence G description BINDING SITE FOR CHAIN P OF CAPSID-P2 SUBSTRATE PEPTIDE OF HIV-1 GAG POLYPROTEIN source : AC4 7) chain B residue 28 type sequence A description BINDING SITE FOR CHAIN P OF CAPSID-P2 SUBSTRATE PEPTIDE OF HIV-1 GAG POLYPROTEIN source : AC4 8) chain B residue 29 type sequence D description BINDING SITE FOR CHAIN P OF CAPSID-P2 SUBSTRATE PEPTIDE OF HIV-1 GAG POLYPROTEIN source : AC4 9) chain B residue 30 type sequence D description BINDING SITE FOR CHAIN P OF CAPSID-P2 SUBSTRATE PEPTIDE OF HIV-1 GAG POLYPROTEIN source : AC4 10) chain B residue 47 type sequence I description BINDING SITE FOR CHAIN P OF CAPSID-P2 SUBSTRATE PEPTIDE OF HIV-1 GAG POLYPROTEIN source : AC4 11) chain B residue 48 type sequence G description BINDING SITE FOR CHAIN P OF CAPSID-P2 SUBSTRATE PEPTIDE OF HIV-1 GAG POLYPROTEIN source : AC4 12) chain B residue 49 type sequence G description BINDING SITE FOR CHAIN P OF CAPSID-P2 SUBSTRATE PEPTIDE OF HIV-1 GAG POLYPROTEIN source : AC4 13) chain B residue 81 type sequence P description BINDING SITE FOR CHAIN P OF CAPSID-P2 SUBSTRATE PEPTIDE OF HIV-1 GAG POLYPROTEIN source : AC4 14) chain B residue 78 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 15) chain B residue 78 type MOD_RES sequence G description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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