eF-site ID 1mt8-A PDB Code 1mt8 Chain A click to enlarge Title Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy Classification HYDROLASE/HYDROLASE SUBSTRATE Compound PROTEASE RETROPEPSIN Source Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) (Q9YX54_9HIV1) Sequence A:  PQITLWKRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEICGHKAIGTVLVGPT PANIIGRNLLTQIGCTLNF Description Functional site 1) chain A residue 1 type sequence P description BINDING SITE FOR RESIDUE ACT B 501 source : AC1 2) chain A residue 14 type sequence R description BINDING SITE FOR RESIDUE ACT B 503 source : AC2 3) chain A residue 16 type sequence G description BINDING SITE FOR RESIDUE ACT B 503 source : AC2 4) chain A residue 8 type sequence R description BINDING SITE FOR CHAIN P OF CAPSID-P2 SUBSTRATE PEPTIDE OF HIV-1 GAG POLYPROTEIN source : AC4 5) chain A residue 25 type sequence N description BINDING SITE FOR CHAIN P OF CAPSID-P2 SUBSTRATE PEPTIDE OF HIV-1 GAG POLYPROTEIN source : AC4 6) chain A residue 27 type sequence G description BINDING SITE FOR CHAIN P OF CAPSID-P2 SUBSTRATE PEPTIDE OF HIV-1 GAG POLYPROTEIN source : AC4 7) chain A residue 28 type sequence A description BINDING SITE FOR CHAIN P OF CAPSID-P2 SUBSTRATE PEPTIDE OF HIV-1 GAG POLYPROTEIN source : AC4 8) chain A residue 29 type sequence D description BINDING SITE FOR CHAIN P OF CAPSID-P2 SUBSTRATE PEPTIDE OF HIV-1 GAG POLYPROTEIN source : AC4 9) chain A residue 30 type sequence D description BINDING SITE FOR CHAIN P OF CAPSID-P2 SUBSTRATE PEPTIDE OF HIV-1 GAG POLYPROTEIN source : AC4 10) chain A residue 48 type sequence G description BINDING SITE FOR CHAIN P OF CAPSID-P2 SUBSTRATE PEPTIDE OF HIV-1 GAG POLYPROTEIN source : AC4 11) chain A residue 49 type sequence G description BINDING SITE FOR CHAIN P OF CAPSID-P2 SUBSTRATE PEPTIDE OF HIV-1 GAG POLYPROTEIN source : AC4 12) chain A residue 50 type sequence I description BINDING SITE FOR CHAIN P OF CAPSID-P2 SUBSTRATE PEPTIDE OF HIV-1 GAG POLYPROTEIN source : AC4 13) chain A residue 84 type sequence I description BINDING SITE FOR CHAIN P OF CAPSID-P2 SUBSTRATE PEPTIDE OF HIV-1 GAG POLYPROTEIN source : AC4 14) chain A residue 78 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 78 type MOD_RES sequence G description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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