eF-site ID 1mr1-ABCD PDB Code 1mr1 Chain A, B, C, D click to enlarge Title Crystal Structure of a Smad4-Ski Complex Classification SIGNALING PROTEIN Compound Mothers against decapentaplegic homolog 4 Source Homo sapiens (Human) (SKI_HUMAN) Sequence A:  APEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSG GDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVW VRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVF DLRQCHRQMQQQAATAQAAAAAQVDDLRRLCILRMSFVKG WGPDYPRQSIKETPCWIEIHLHRALQLLDEVLHTM B:  APEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSG GDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVW VRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVF DLRQCHRQMQQQAAVDDLRRLCILRMSFVKGWGPDYPRQS IKETPCWIEIHLHRALQLLDEVLHTMPIADPQP C:  SHMRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYP PHKFVVHSHKALENRTCHWGFDSANWRAYILLSQDYTGKE EQARLGRCLDDVKEKFD D:  HMRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPP HKFVVHSHKALENRTCHWGFDSANWRAYILLSQDYTGKEE QARLGRCLDDVKEKFD Description Functional site 1) chain C residue 247 type sequence C description BINDING SITE FOR RESIDUE ZN C 601 source : AC1 2) chain C residue 250 type sequence C description BINDING SITE FOR RESIDUE ZN C 601 source : AC1 3) chain C residue 262 type sequence H description BINDING SITE FOR RESIDUE ZN C 601 source : AC1 4) chain C residue 264 type sequence H description BINDING SITE FOR RESIDUE ZN C 601 source : AC1 5) chain D residue 247 type sequence C description BINDING SITE FOR RESIDUE ZN D 602 source : AC2 6) chain D residue 250 type sequence C description BINDING SITE FOR RESIDUE ZN D 602 source : AC2 7) chain D residue 262 type sequence H description BINDING SITE FOR RESIDUE ZN D 602 source : AC2 8) chain D residue 264 type sequence H description BINDING SITE FOR RESIDUE ZN D 602 source : AC2 9) chain A residue 515 type SITE sequence R description Necessary for heterotrimerization source Swiss-Prot : SWS_FT_FI1 10) chain B residue 515 type SITE sequence R description Necessary for heterotrimerization source Swiss-Prot : SWS_FT_FI1 11) chain A residue 428 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 12) chain A residue 507 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 13) chain B residue 428 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 14) chain B residue 507 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 519 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19135894 source Swiss-Prot : SWS_FT_FI3 16) chain B residue 519 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19135894 source Swiss-Prot : SWS_FT_FI3

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