eF-site ID 1mmp-AB PDB Code 1mmp Chain A, B click to enlarge Title MATRILYSIN COMPLEXED WITH CARBOXYLATE INHIBITOR Classification METALLOPROTEASE Compound GELATINASE A Source Homo sapiens (Human) (MMP7_HUMAN) Sequence A:  YSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALN MWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGN TLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATH ELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGI QKLYGK B:  YSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALN MWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGN TLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATH ELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGI QKLYGK Description Functional site 1) chain A residue 218 type sequence H description BINDING SITE FOR RESIDUE ZN A 1 source : AC1 2) chain A residue 222 type sequence H description BINDING SITE FOR RESIDUE ZN A 1 source : AC1 3) chain A residue 228 type sequence H description BINDING SITE FOR RESIDUE ZN A 1 source : AC1 4) chain A residue 168 type sequence H description BINDING SITE FOR RESIDUE ZN A 2 source : AC2 5) chain A residue 170 type sequence D description BINDING SITE FOR RESIDUE ZN A 2 source : AC2 6) chain A residue 183 type sequence H description BINDING SITE FOR RESIDUE ZN A 2 source : AC2 7) chain A residue 196 type sequence H description BINDING SITE FOR RESIDUE ZN A 2 source : AC2 8) chain A residue 158 type sequence D description BINDING SITE FOR RESIDUE CA A 3 source : AC3 9) chain A residue 190 type sequence G description BINDING SITE FOR RESIDUE CA A 3 source : AC3 10) chain A residue 192 type sequence G description BINDING SITE FOR RESIDUE CA A 3 source : AC3 11) chain A residue 194 type sequence D description BINDING SITE FOR RESIDUE CA A 3 source : AC3 12) chain A residue 175 type sequence D description BINDING SITE FOR RESIDUE CA A 4 source : AC4 13) chain A residue 176 type sequence G description BINDING SITE FOR RESIDUE CA A 4 source : AC4 14) chain A residue 178 type sequence G description BINDING SITE FOR RESIDUE CA A 4 source : AC4 15) chain A residue 180 type sequence T description BINDING SITE FOR RESIDUE CA A 4 source : AC4 16) chain A residue 198 type sequence D description BINDING SITE FOR RESIDUE CA A 4 source : AC4 17) chain A residue 201 type sequence E description BINDING SITE FOR RESIDUE CA A 4 source : AC4 18) chain B residue 218 type sequence H description BINDING SITE FOR RESIDUE ZN B 1 source : AC5 19) chain B residue 222 type sequence H description BINDING SITE FOR RESIDUE ZN B 1 source : AC5 20) chain B residue 228 type sequence H description BINDING SITE FOR RESIDUE ZN B 1 source : AC5 21) chain B residue 168 type sequence H description BINDING SITE FOR RESIDUE ZN B 2 source : AC6 22) chain B residue 170 type sequence D description BINDING SITE FOR RESIDUE ZN B 2 source : AC6 23) chain B residue 183 type sequence H description BINDING SITE FOR RESIDUE ZN B 2 source : AC6 24) chain B residue 196 type sequence H description BINDING SITE FOR RESIDUE ZN B 2 source : AC6 25) chain B residue 158 type sequence D description BINDING SITE FOR RESIDUE CA B 3 source : AC7 26) chain B residue 190 type sequence G description BINDING SITE FOR RESIDUE CA B 3 source : AC7 27) chain B residue 192 type sequence G description BINDING SITE FOR RESIDUE CA B 3 source : AC7 28) chain B residue 194 type sequence D description BINDING SITE FOR RESIDUE CA B 3 source : AC7 29) chain B residue 175 type sequence D description BINDING SITE FOR RESIDUE CA B 4 source : AC8 30) chain B residue 176 type sequence G description BINDING SITE FOR RESIDUE CA B 4 source : AC8 31) chain B residue 178 type sequence G description BINDING SITE FOR RESIDUE CA B 4 source : AC8 32) chain B residue 180 type sequence T description BINDING SITE FOR RESIDUE CA B 4 source : AC8 33) chain B residue 198 type sequence D description BINDING SITE FOR RESIDUE CA B 4 source : AC8 34) chain B residue 201 type sequence E description BINDING SITE FOR RESIDUE CA B 4 source : AC8 35) chain A residue 179 type sequence N description BINDING SITE FOR RESIDUE RSS A 269 source : AC9 36) chain A residue 181 type sequence L description BINDING SITE FOR RESIDUE RSS A 269 source : AC9 37) chain A residue 182 type sequence A description BINDING SITE FOR RESIDUE RSS A 269 source : AC9 38) chain A residue 218 type sequence H description BINDING SITE FOR RESIDUE RSS A 269 source : AC9 39) chain A residue 219 type sequence E description BINDING SITE FOR RESIDUE RSS A 269 source : AC9 40) chain A residue 222 type sequence H description BINDING SITE FOR RESIDUE RSS A 269 source : AC9 41) chain A residue 228 type sequence H description BINDING SITE FOR RESIDUE RSS A 269 source : AC9 42) chain A residue 238 type sequence P description BINDING SITE FOR RESIDUE RSS A 269 source : AC9 43) chain A residue 239 type sequence T description BINDING SITE FOR RESIDUE RSS A 269 source : AC9 44) chain A residue 240 type sequence Y description BINDING SITE FOR RESIDUE RSS A 269 source : AC9 45) chain B residue 232 type sequence P description BINDING SITE FOR RESIDUE RSS A 269 source : AC9 46) chain B residue 242 type sequence N description BINDING SITE FOR RESIDUE RSS A 269 source : AC9 47) chain A residue 232 type sequence P description BINDING SITE FOR RESIDUE RSS B 269 source : BC1 48) chain A residue 242 type sequence N description BINDING SITE FOR RESIDUE RSS B 269 source : BC1 49) chain B residue 179 type sequence N description BINDING SITE FOR RESIDUE RSS B 269 source : BC1 50) chain B residue 181 type sequence L description BINDING SITE FOR RESIDUE RSS B 269 source : BC1 51) chain B residue 182 type sequence A description BINDING SITE FOR RESIDUE RSS B 269 source : BC1 52) chain B residue 218 type sequence H description BINDING SITE FOR RESIDUE RSS B 269 source : BC1 53) chain B residue 219 type sequence E description BINDING SITE FOR RESIDUE RSS B 269 source : BC1 54) chain B residue 222 type sequence H description BINDING SITE FOR RESIDUE RSS B 269 source : BC1 55) chain B residue 228 type sequence H description BINDING SITE FOR RESIDUE RSS B 269 source : BC1 56) chain B residue 238 type sequence P description BINDING SITE FOR RESIDUE RSS B 269 source : BC1 57) chain B residue 239 type sequence T description BINDING SITE FOR RESIDUE RSS B 269 source : BC1 58) chain B residue 240 type sequence Y description BINDING SITE FOR RESIDUE RSS B 269 source : BC1 59) chain A residue 158 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 60) chain A residue 192 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 61) chain A residue 194 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 62) chain A residue 196 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 63) chain A residue 198 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 64) chain A residue 201 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 65) chain A residue 218 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 66) chain A residue 222 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 67) chain A residue 228 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 68) chain B residue 158 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 69) chain B residue 168 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 70) chain A residue 168 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 71) chain B residue 170 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 72) chain B residue 175 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 73) chain B residue 176 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 74) chain B residue 178 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 75) chain B residue 180 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI2 76) chain B residue 183 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 77) chain B residue 190 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 78) chain B residue 192 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 79) chain B residue 194 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 80) chain B residue 196 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 81) chain A residue 170 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 82) chain B residue 198 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 83) chain B residue 201 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 84) chain B residue 218 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 85) chain B residue 222 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 86) chain B residue 228 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 87) chain A residue 175 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 88) chain A residue 176 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 89) chain A residue 178 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 90) chain A residue 180 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI2 91) chain A residue 183 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 92) chain A residue 190 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 93) chain A residue 219 type ACT_SITE sequence E description source Swiss-Prot : SWS_FT_FI1 94) chain B residue 219 type ACT_SITE sequence E description source Swiss-Prot : SWS_FT_FI1 95) chain A residue 215-224 type prosite sequence AATHELGHSL description ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. AATHELGHSL source prosite : PS00142

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