eF-site ID 1mlc-ABCDEF PDB Code 1mlc Chain A, B, C, D, E, F click to enlarge Title MONOCLONAL ANTIBODY FAB D44.1 RAISED AGAINST CHICKEN EGG-WHITE LYSOZYME COMPLEXED WITH LYSOZYME Classification COMPLEX (ANTIBODY/ANTIGEN) Compound IGG1-KAPPA D44.1 FAB (LIGHT CHAIN) Source Gallus gallus (Chicken) (1MLC) Sequence A:  DIELTQSPATLSVTPGDSVSLSCRASQSISNNLHWYQQKS HESPRLLIKYVSQSSSGIPSRFSGSGSGTDFTLSINSVET EDFGMYFCQQSNSWPRTFGGGTKLEIKRADAAPTVSIFPP SSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVL NSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKT STSPIVKSFNRNEC B:  QVQLQESGAEVMKPGASVKISCKATGYTFSTYWIEWVKQR PGHGLEWIGEILPGSGSTYYNEKFKGKATFTADTSSNTAY MQLSSLTSEDSAVYYCARGDGNYGYWGQGTTLTVSSASTT PPSVFPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSG SLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNV AHPASSTKVDKKIVPRDC C:  DIELTQSPATLSVTPGDSVSLSCRASQSISNNLHWYQQKS HESPRLLIKYVSQSSSGIPSRFSGSGSGTDFTLSINSVET EDFGMYFCQQSNSWPRTFGGGTKLEIKRADAAPTVSIFPP SSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVL NSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKT STSPIVKSFNRNEC D:  QVQLQESGAEVMKPGASVKISCKATGYTFSTYWIEWVKQR PGHGLEWIGEILPGSGSTYYNEKFKGKATFTADTSSNTAY MQLSSLTSEDSAVYYCARGDGNYGYWGQGTTLTVSSASTT PPSVFPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSG SLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNV AHPASSTKVDKKIVPRDC E:  KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNT QATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPC SALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDV QAWIRGCRL F:  KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNT QATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPC SALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDV QAWIRGCRL Description (1)  FAB D44.1 (IGG1,KAPPA) (BALB/C MOUSE, MONOCLONAL ANTIBODY) COMPLEXED WITH HEN EGG-WHITE LYSOZYME (HEL) Functional site 1) chain E residue 35 type catalytic sequence E description 203 source MCSA : MCSA1 2) chain E residue 46 type catalytic sequence N description 203 source MCSA : MCSA1 3) chain E residue 48 type catalytic sequence D description 203 source MCSA : MCSA1 4) chain E residue 50 type catalytic sequence S description 203 source MCSA : MCSA1 5) chain E residue 52 type catalytic sequence D description 203 source MCSA : MCSA1 6) chain E residue 59 type catalytic sequence N description 203 source MCSA : MCSA1 7) chain F residue 35 type catalytic sequence E description 203 source MCSA : MCSA2 8) chain F residue 46 type catalytic sequence N description 203 source MCSA : MCSA2 9) chain F residue 48 type catalytic sequence D description 203 source MCSA : MCSA2 10) chain F residue 50 type catalytic sequence S description 203 source MCSA : MCSA2 11) chain F residue 52 type catalytic sequence D description 203 source MCSA : MCSA2 12) chain F residue 59 type catalytic sequence N description 203 source MCSA : MCSA2 13) chain E residue 76-94 type prosite sequence CNIPCSALLSSDITASVNC description GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. CnipCsaLlssDItasvnC source prosite : PS00128 14) chain A residue 192-198 type prosite sequence YTCEATH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH source prosite : PS00290 15) chain E residue 35 type ACT_SITE sequence E description source Swiss-Prot : SWS_FT_FI1 16) chain E residue 52 type ACT_SITE sequence D description source Swiss-Prot : SWS_FT_FI1 17) chain F residue 35 type ACT_SITE sequence E description source Swiss-Prot : SWS_FT_FI1 18) chain F residue 52 type ACT_SITE sequence D description source Swiss-Prot : SWS_FT_FI1 19) chain E residue 101 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 20) chain F residue 101 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2

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