eF-site ID 1m9d-A
PDB Code 1m9d
Chain A

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Title X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) O-type chimera Complex.
Classification Isomerase/Viral protein
Compound Cyclophilin A
Source Homo sapiens (Human) (Q72497_9HIV1)
Sequence A:  MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALS
TGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYG
EKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTE
WLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIAD
CGQLE
Description


Functional site

1) chain A
residue 55
type catalytic
sequence R
description 189
source MCSA : MCSA1

2) chain A
residue 60
type catalytic
sequence F
description 189
source MCSA : MCSA1

3) chain A
residue 63
type catalytic
sequence Q
description 189
source MCSA : MCSA1

4) chain A
residue 102
type catalytic
sequence N
description 189
source MCSA : MCSA1

5) chain A
residue 113
type catalytic
sequence F
description 189
source MCSA : MCSA1

6) chain A
residue 122
type catalytic
sequence L
description 189
source MCSA : MCSA1

7) chain A
residue 126
type catalytic
sequence H
description 189
source MCSA : MCSA1

8) chain A
residue 125
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000269|PubMed:20364129, ECO:0000269|PubMed:25678563, ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI7

9) chain A
residue 44
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI4

10) chain A
residue 76
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI4

11) chain A
residue 131
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI4

12) chain A
residue 133
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000250|UniProtKB:P17742
source Swiss-Prot : SWS_FT_FI8

13) chain A
residue 108
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI9

14) chain A
residue 28
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
source Swiss-Prot : SWS_FT_FI10

15) chain A
residue 82
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI11

16) chain A
residue 28
type MOD_RES
sequence K
description N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI3

17) chain A
residue 82
type MOD_RES
sequence K
description N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI3

18) chain A
residue 77
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI5

19) chain A
residue 93
type MOD_RES
sequence T
description Phosphothreonine => ECO:0007744|PubMed:20068231
source Swiss-Prot : SWS_FT_FI6

20) chain A
residue 48-65
type prosite
sequence YKGSCFHRIIPGFMCQGG
description CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgScFHRIIpgFMcQGG
source prosite : PS00170


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