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eF-site ID
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1m5n-QS |
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PDB Code
|
1m5n |
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Chain
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Q, S |
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click to enlarge
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Title
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Crystal structure of HEAT repeats (1-11) of importin b bound to the non-classical NLS(67-94) of PTHrP |
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Classification
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PROTEIN TRANSPORT |
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Compound
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Importin beta-1 subunit |
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Source
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null (PTHR_HUMAN) |
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Sequence
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Q: |
YLTQETNKVETYKEQPLKTPGKKKKGKP
|
| S: |
MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVEL
SRVLANPGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRW
LAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE
IPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQD
IDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLN
SLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQN
LVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGI
EFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQ
YLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCE
DDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPS
QLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLP
EAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEA
AYEAA
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Description
|
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Functional site
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|
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1)
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chain |
S |
| residue |
1 |
| type |
MOD_RES |
| sequence |
M
|
| description |
N-acetylmethionine => ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
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| source |
Swiss-Prot : SWS_FT_FI1
|
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2)
|
chain |
S |
| residue |
12 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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3)
|
chain |
S |
| residue |
211 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine => ECO:0007744|PubMed:19608861
|
| source |
Swiss-Prot : SWS_FT_FI3
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