eF-site ID 1m35-ABCDEF PDB Code 1m35 Chain A, B, C, D, E, F click to enlarge Title Aminopeptidase P from Escherichia coli Classification HYDROLASE Compound AMINOPEPTIDASE P Source Escherichia coli (strain K12) (AMPP_ECOLI) Sequence A:  SEISRQEFQRRRQALVEQMQPGSAALIFAAPEVTRSADSE YPYRQNSDFWYFTGFNEPEAVLVLIKSDDTHNHSVLFNRV RDLTAEIWFGRRLGQDAAPEKLGVDRALAFSEINQQLYQL LNGLDVVYHAQGEYAYADVIVNSALEKLRKGSRQNLTAPA TMIDWRPVVHEMRLFKSPEEIAVLRRAGEITAMAHTRAME KCRPGMFEYHLEGEIHHEFNRHGARYPSYNTIVGSGENGC ILHYTENECEMRDGDLVLIDAGCEYKGYAGDITRTFPVNG KFTQAQREIYDIVLESLETSLRLYRPGTSILEVTGEVVRI MVSGLVKLGILKGDVDELIAQNAHRPFFMHGLSHWLGLDV HDVGVYGQDRSRILEPGMVLTVEPGLYIAPDAEVPEQYRG IGIRIEDDIVITETGNENLTASVVKKPEEIEALMVAARKQ B:  SEISRQEFQRRRQALVEQMQPGSAALIFAAPEVTRSADSE YPYRQNSDFWYFTGFNEPEAVLVLIKSDDTHNHSVLFNRV RDLTAEIWFGRRLGQDAAPEKLGVDRALAFSEINQQLYQL LNGLDVVYHAQGEYAYADVIVNSALEKLRKGSRQNLTAPA TMIDWRPVVHEMRLFKSPEEIAVLRRAGEITAMAHTRAME KCRPGMFEYHLEGEIHHEFNRHGARYPSYNTIVGSGENGC ILHYTENECEMRDGDLVLIDAGCEYKGYAGDITRTFPVNG KFTQAQREIYDIVLESLETSLRLYRPGTSILEVTGEVVRI MVSGLVKLGILKGDVDELIAQNAHRPFFMHGLSHWLGLDV HDVGVYGQDRSRILEPGMVLTVEPGLYIAPDAEVPEQYRG IGIRIEDDIVITETGNENLTASVVKKPEEIEALMVAARKQ C:  SEISRQEFQRRRQALVEQMQPGSAALIFAAPEVTRSADSE YPYRQNSDFWYFTGFNEPEAVLVLIKSDDTHNHSVLFNRV RDLTAEIWFGRRLGQDAAPEKLGVDRALAFSEINQQLYQL LNGLDVVYHAQGEYAYADVIVNSALEKLRKGSRQNLTAPA TMIDWRPVVHEMRLFKSPEEIAVLRRAGEITAMAHTRAME KCRPGMFEYHLEGEIHHEFNRHGARYPSYNTIVGSGENGC ILHYTENECEMRDGDLVLIDAGCEYKGYAGDITRTFPVNG KFTQAQREIYDIVLESLETSLRLYRPGTSILEVTGEVVRI MVSGLVKLGILKGDVDELIAQNAHRPFFMHGLSHWLGLDV HDVGVYGQDRSRILEPGMVLTVEPGLYIAPDAEVPEQYRG IGIRIEDDIVITETGNENLTASVVKKPEEIEALMVAARKQ D:  SEISRQEFQRRRQALVEQMQPGSAALIFAAPEVTRSADSE YPYRQNSDFWYFTGFNEPEAVLVLIKSDDTHNHSVLFNRV RDLTAEIWFGRRLGQDAAPEKLGVDRALAFSEINQQLYQL LNGLDVVYHAQGEYAYADVIVNSALEKLRKGSRQNLTAPA TMIDWRPVVHEMRLFKSPEEIAVLRRAGEITAMAHTRAME KCRPGMFEYHLEGEIHHEFNRHGARYPSYNTIVGSGENGC ILHYTENECEMRDGDLVLIDAGCEYKGYAGDITRTFPVNG KFTQAQREIYDIVLESLETSLRLYRPGTSILEVTGEVVRI MVSGLVKLGILKGDVDELIAQNAHRPFFMHGLSHWLGLDV HDVGVYGQDRSRILEPGMVLTVEPGLYIAPDAEVPEQYRG IGIRIEDDIVITETGNENLTASVVKKPEEIEALMVAARKQ E:  SEISRQEFQRRRQALVEQMQPGSAALIFAAPEVTRSADSE YPYRQNSDFWYFTGFNEPEAVLVLIKSDDTHNHSVLFNRV RDLTAEIWFGRRLGQDAAPEKLGVDRALAFSEINQQLYQL LNGLDVVYHAQGEYAYADVIVNSALEKLRKGSRQNLTAPA TMIDWRPVVHEMRLFKSPEEIAVLRRAGEITAMAHTRAME KCRPGMFEYHLEGEIHHEFNRHGARYPSYNTIVGSGENGC ILHYTENECEMRDGDLVLIDAGCEYKGYAGDITRTFPVNG KFTQAQREIYDIVLESLETSLRLYRPGTSILEVTGEVVRI MVSGLVKLGILKGDVDELIAQNAHRPFFMHGLSHWLGLDV HDVGVYGQDRSRILEPGMVLTVEPGLYIAPDAEVPEQYRG IGIRIEDDIVITETGNENLTASVVKKPEEIEALMVAARKQ F:  SEISRQEFQRRRQALVEQMQPGSAALIFAAPEVTRSADSE YPYRQNSDFWYFTGFNEPEAVLVLIKSDDTHNHSVLFNRV RDLTAEIWFGRRLGQDAAPEKLGVDRALAFSEINQQLYQL LNGLDVVYHAQGEYAYADVIVNSALEKLRKGSRQNLTAPA TMIDWRPVVHEMRLFKSPEEIAVLRRAGEITAMAHTRAME KCRPGMFEYHLEGEIHHEFNRHGARYPSYNTIVGSGENGC ILHYTENECEMRDGDLVLIDAGCEYKGYAGDITRTFPVNG KFTQAQREIYDIVLESLETSLRLYRPGTSILEVTGEVVRI MVSGLVKLGILKGDVDELIAQNAHRPFFMHGLSHWLGLDV HDVGVYGQDRSRILEPGMVLTVEPGLYIAPDAEVPEQYRG IGIRIEDDIVITETGNENLTASVVKKPEEIEALMVAARKQ Description Functional site 1) chain A residue 260 type sequence D description BINDING SITE FOR RESIDUE MN A 2001 source : AC1 2) chain A residue 271 type sequence D description BINDING SITE FOR RESIDUE MN A 2001 source : AC1 3) chain A residue 273 type sequence T description BINDING SITE FOR RESIDUE MN A 2001 source : AC1 4) chain A residue 406 type sequence E description BINDING SITE FOR RESIDUE MN A 2001 source : AC1 5) chain A residue 271 type sequence D description BINDING SITE FOR RESIDUE MN A 2002 source : AC2 6) chain A residue 354 type sequence H description BINDING SITE FOR RESIDUE MN A 2002 source : AC2 7) chain A residue 383 type sequence E description BINDING SITE FOR RESIDUE MN A 2002 source : AC2 8) chain A residue 406 type sequence E description BINDING SITE FOR RESIDUE MN A 2002 source : AC2 9) chain B residue 260 type sequence D description BINDING SITE FOR RESIDUE MN B 2003 source : AC3 10) chain B residue 271 type sequence D description BINDING SITE FOR RESIDUE MN B 2003 source : AC3 11) chain B residue 273 type sequence T description BINDING SITE FOR RESIDUE MN B 2003 source : AC3 12) chain B residue 406 type sequence E description BINDING SITE FOR RESIDUE MN B 2003 source : AC3 13) chain B residue 271 type sequence D description BINDING SITE FOR RESIDUE MN B 2004 source : AC4 14) chain B residue 354 type sequence H description BINDING SITE FOR RESIDUE MN B 2004 source : AC4 15) chain B residue 383 type sequence E description BINDING SITE FOR RESIDUE MN B 2004 source : AC4 16) chain B residue 406 type sequence E description BINDING SITE FOR RESIDUE MN B 2004 source : AC4 17) chain C residue 229 type sequence Y description BINDING SITE FOR RESIDUE MN C 2005 source : AC5 18) chain C residue 260 type sequence D description BINDING SITE FOR RESIDUE MN C 2005 source : AC5 19) chain C residue 271 type sequence D description BINDING SITE FOR RESIDUE MN C 2005 source : AC5 20) chain C residue 273 type sequence T description BINDING SITE FOR RESIDUE MN C 2005 source : AC5 21) chain C residue 406 type sequence E description BINDING SITE FOR RESIDUE MN C 2005 source : AC5 22) chain C residue 271 type sequence D description BINDING SITE FOR RESIDUE MN C 2006 source : AC6 23) chain C residue 354 type sequence H description BINDING SITE FOR RESIDUE MN C 2006 source : AC6 24) chain C residue 383 type sequence E description BINDING SITE FOR RESIDUE MN C 2006 source : AC6 25) chain C residue 406 type sequence E description BINDING SITE FOR RESIDUE MN C 2006 source : AC6 26) chain D residue 260 type sequence D description BINDING SITE FOR RESIDUE MN D 2007 source : AC7 27) chain D residue 271 type sequence D description BINDING SITE FOR RESIDUE MN D 2007 source : AC7 28) chain D residue 273 type sequence T description BINDING SITE FOR RESIDUE MN D 2007 source : AC7 29) chain D residue 406 type sequence E description BINDING SITE FOR RESIDUE MN D 2007 source : AC7 30) chain D residue 271 type sequence D description BINDING SITE FOR RESIDUE MN D 2008 source : AC8 31) chain D residue 354 type sequence H description BINDING SITE FOR RESIDUE MN D 2008 source : AC8 32) chain D residue 383 type sequence E description BINDING SITE FOR RESIDUE MN D 2008 source : AC8 33) chain D residue 406 type sequence E description BINDING SITE FOR RESIDUE MN D 2008 source : AC8 34) chain E residue 229 type sequence Y description BINDING SITE FOR RESIDUE MN E 2009 source : AC9 35) chain E residue 260 type sequence D description BINDING SITE FOR RESIDUE MN E 2009 source : AC9 36) chain E residue 271 type sequence D description BINDING SITE FOR RESIDUE MN E 2009 source : AC9 37) chain E residue 273 type sequence T description BINDING SITE FOR RESIDUE MN E 2009 source : AC9 38) chain E residue 406 type sequence E description BINDING SITE FOR RESIDUE MN E 2009 source : AC9 39) chain E residue 271 type sequence D description BINDING SITE FOR RESIDUE MN E 2010 source : BC1 40) chain E residue 354 type sequence H description BINDING SITE FOR RESIDUE MN E 2010 source : BC1 41) chain E residue 383 type sequence E description BINDING SITE FOR RESIDUE MN E 2010 source : BC1 42) chain E residue 406 type sequence E description BINDING SITE FOR RESIDUE MN E 2010 source : BC1 43) chain F residue 229 type sequence Y description BINDING SITE FOR RESIDUE MN F 2011 source : BC2 44) chain F residue 260 type sequence D description BINDING SITE FOR RESIDUE MN F 2011 source : BC2 45) chain F residue 271 type sequence D description BINDING SITE FOR RESIDUE MN F 2011 source : BC2 46) chain F residue 273 type sequence T description BINDING SITE FOR RESIDUE MN F 2011 source : BC2 47) chain F residue 406 type sequence E description BINDING SITE FOR RESIDUE MN F 2011 source : BC2 48) chain F residue 271 type sequence D description BINDING SITE FOR RESIDUE MN F 2012 source : BC3 49) chain F residue 354 type sequence H description BINDING SITE FOR RESIDUE MN F 2012 source : BC3 50) chain F residue 383 type sequence E description BINDING SITE FOR RESIDUE MN F 2012 source : BC3 51) chain F residue 406 type sequence E description BINDING SITE FOR RESIDUE MN F 2012 source : BC3 52) chain A residue 39 type catalytic sequence S description 379 source MCSA : MCSA1 53) chain A residue 405 type catalytic sequence I description 379 source MCSA : MCSA1 54) chain A residue 407 type catalytic sequence D description 379 source MCSA : MCSA1 55) chain A residue 244 type catalytic sequence Y description 379 source MCSA : MCSA1 56) chain A residue 261 type catalytic sequence A description 379 source MCSA : MCSA1 57) chain A residue 272 type catalytic sequence I description 379 source MCSA : MCSA1 58) chain A residue 351 type catalytic sequence G description 379 source MCSA : MCSA1 59) chain A residue 355 type catalytic sequence W description 379 source MCSA : MCSA1 60) chain A residue 362 type catalytic sequence D description 379 source MCSA : MCSA1 61) chain A residue 384 type catalytic sequence P description 379 source MCSA : MCSA1 62) chain A residue 388 type catalytic sequence I description 379 source MCSA : MCSA1 63) chain B residue 39 type catalytic sequence S description 379 source MCSA : MCSA2 64) chain B residue 405 type catalytic sequence I description 379 source MCSA : MCSA2 65) chain B residue 407 type catalytic sequence D description 379 source MCSA : MCSA2 66) chain B residue 244 type catalytic sequence Y description 379 source MCSA : MCSA2 67) chain B residue 261 type catalytic sequence A description 379 source MCSA : MCSA2 68) chain B residue 272 type catalytic sequence I description 379 source MCSA : MCSA2 69) chain B residue 351 type catalytic sequence G description 379 source MCSA : MCSA2 70) chain B residue 355 type catalytic sequence W description 379 source MCSA : MCSA2 71) chain B residue 362 type catalytic sequence D description 379 source MCSA : MCSA2 72) chain B residue 384 type catalytic sequence P description 379 source MCSA : MCSA2 73) chain B residue 388 type catalytic sequence I description 379 source MCSA : MCSA2 74) chain C residue 39 type catalytic sequence S description 379 source MCSA : MCSA3 75) chain C residue 405 type catalytic sequence I description 379 source MCSA : MCSA3 76) chain C residue 407 type catalytic sequence D description 379 source MCSA : MCSA3 77) chain C residue 244 type catalytic sequence Y description 379 source MCSA : MCSA3 78) chain C residue 261 type catalytic sequence A description 379 source MCSA : MCSA3 79) chain C residue 272 type catalytic sequence I description 379 source MCSA : MCSA3 80) chain C residue 351 type catalytic sequence G description 379 source MCSA : MCSA3 81) chain C residue 355 type catalytic sequence W description 379 source MCSA : MCSA3 82) chain C residue 362 type catalytic sequence D description 379 source MCSA : MCSA3 83) chain C residue 384 type catalytic sequence P description 379 source MCSA : MCSA3 84) chain C residue 388 type catalytic sequence I description 379 source MCSA : MCSA3 85) chain D residue 39 type catalytic sequence S description 379 source MCSA : MCSA4 86) chain D residue 405 type catalytic sequence I description 379 source MCSA : MCSA4 87) chain D residue 407 type catalytic sequence D description 379 source MCSA : MCSA4 88) chain D residue 244 type catalytic sequence Y description 379 source MCSA : MCSA4 89) chain D residue 261 type catalytic sequence A description 379 source MCSA : MCSA4 90) chain D residue 272 type catalytic sequence I description 379 source MCSA : MCSA4 91) chain D residue 351 type catalytic sequence G description 379 source MCSA : MCSA4 92) chain D residue 355 type catalytic sequence W description 379 source MCSA : MCSA4 93) chain D residue 362 type catalytic sequence D description 379 source MCSA : MCSA4 94) chain D residue 384 type catalytic sequence P description 379 source MCSA : MCSA4 95) chain D residue 388 type catalytic sequence I description 379 source MCSA : MCSA4 96) chain E residue 39 type catalytic sequence S description 379 source MCSA : MCSA5 97) chain E residue 405 type catalytic sequence I description 379 source MCSA : MCSA5 98) chain E residue 407 type catalytic sequence D description 379 source MCSA : MCSA5 99) chain E residue 244 type catalytic sequence Y description 379 source MCSA : MCSA5 100) chain E residue 261 type catalytic sequence A description 379 source MCSA : MCSA5 101) chain E residue 272 type catalytic sequence I description 379 source MCSA : MCSA5 102) chain E residue 351 type catalytic sequence G description 379 source MCSA : MCSA5 103) chain E residue 355 type catalytic sequence W description 379 source MCSA : MCSA5 104) chain E residue 362 type catalytic sequence D description 379 source MCSA : MCSA5 105) chain E residue 384 type catalytic sequence P description 379 source MCSA : MCSA5 106) chain E residue 388 type catalytic sequence I description 379 source MCSA : MCSA5 107) chain F residue 39 type catalytic sequence S description 379 source MCSA : MCSA6 108) chain F residue 405 type catalytic sequence I description 379 source MCSA : MCSA6 109) chain F residue 407 type catalytic sequence D description 379 source MCSA : MCSA6 110) chain F residue 244 type catalytic sequence Y description 379 source MCSA : MCSA6 111) chain F residue 261 type catalytic sequence A description 379 source MCSA : MCSA6 112) chain F residue 272 type catalytic sequence I description 379 source MCSA : MCSA6 113) chain F residue 351 type catalytic sequence G description 379 source MCSA : MCSA6 114) chain F residue 355 type catalytic sequence W description 379 source MCSA : MCSA6 115) chain F residue 362 type catalytic sequence D description 379 source MCSA : MCSA6 116) chain F residue 384 type catalytic sequence P description 379 source MCSA : MCSA6 117) chain F residue 388 type catalytic sequence I description 379 source MCSA : MCSA6 118) chain A residue 261 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI1 119) chain B residue 407 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 120) chain C residue 261 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI1 121) chain C residue 272 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI1 122) chain C residue 355 type BINDING sequence W description source Swiss-Prot : SWS_FT_FI1 123) chain C residue 384 type BINDING sequence P description source Swiss-Prot : SWS_FT_FI1 124) chain C residue 407 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 125) chain D residue 261 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI1 126) chain D residue 272 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI1 127) chain D residue 355 type BINDING sequence W description source Swiss-Prot : SWS_FT_FI1 128) chain D residue 384 type BINDING sequence P description source Swiss-Prot : SWS_FT_FI1 129) chain A residue 272 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI1 130) chain D residue 407 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 131) chain E residue 261 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI1 132) chain E residue 272 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI1 133) chain E residue 355 type BINDING sequence W description source Swiss-Prot : SWS_FT_FI1 134) chain E residue 384 type BINDING sequence P description source Swiss-Prot : SWS_FT_FI1 135) chain E residue 407 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 136) chain F residue 261 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI1 137) chain F residue 272 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI1 138) chain F residue 355 type BINDING sequence W description source Swiss-Prot : SWS_FT_FI1 139) chain F residue 384 type BINDING sequence P description source Swiss-Prot : SWS_FT_FI1 140) chain A residue 355 type BINDING sequence W description source Swiss-Prot : SWS_FT_FI1 141) chain F residue 407 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 142) chain A residue 384 type BINDING sequence P description source Swiss-Prot : SWS_FT_FI1 143) chain A residue 407 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 144) chain B residue 261 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI1 145) chain B residue 272 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI1 146) chain B residue 355 type BINDING sequence W description source Swiss-Prot : SWS_FT_FI1 147) chain B residue 384 type BINDING sequence P description source Swiss-Prot : SWS_FT_FI1 148) chain A residue 350-362 type prosite sequence HGLSHWLGLDVHD description PROLINE_PEPTIDASE Aminopeptidase P and proline dipeptidase signature. HGLSHwLGLdVHD source prosite : PS00491

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