eF-site ID 1m00-A PDB Code 1m00 Chain A click to enlarge Title Rat neuronal NOS heme domain with N-butyl-N'-hydroxyguanidine bound Classification OXIDOREDUCTASE Compound Nitric-oxide synthase Source Rattus norvegicus (Rat) (NOS1_RAT) Sequence A:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLP TKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIE STSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDA RDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGK HDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQG WKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHP KFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYM GTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQA LVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCR GGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPD PWNTHVW Description Functional site 1) chain A residue 417 type sequence G description BINDING SITE FOR RESIDUE ACT A 860 source : AC1 2) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE ACT A 860 source : AC1 3) chain A residue 657 type sequence S description BINDING SITE FOR RESIDUE ACT A 860 source : AC1 4) chain A residue 326 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC3 5) chain A residue 331 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC3 6) chain A residue 409 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC4 7) chain A residue 415 type sequence C description BINDING SITE FOR RESIDUE HEM A 750 source : AC4 8) chain A residue 457 type sequence S description BINDING SITE FOR RESIDUE HEM A 750 source : AC4 9) chain A residue 584 type sequence F description BINDING SITE FOR RESIDUE HEM A 750 source : AC4 10) chain A residue 585 type sequence S description BINDING SITE FOR RESIDUE HEM A 750 source : AC4 11) chain A residue 586 type sequence G description BINDING SITE FOR RESIDUE HEM A 750 source : AC4 12) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC4 13) chain A residue 592 type sequence E description BINDING SITE FOR RESIDUE HEM A 750 source : AC4 14) chain A residue 678 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC4 15) chain A residue 706 type sequence Y description BINDING SITE FOR RESIDUE HEM A 750 source : AC4 16) chain A residue 334 type sequence S description BINDING SITE FOR RESIDUE H4B A 760 source : AC5 17) chain A residue 336 type sequence M description BINDING SITE FOR RESIDUE H4B A 760 source : AC5 18) chain A residue 596 type sequence R description BINDING SITE FOR RESIDUE H4B A 760 source : AC5 19) chain A residue 677 type sequence V description BINDING SITE FOR RESIDUE H4B A 760 source : AC5 20) chain A residue 678 type sequence W description BINDING SITE FOR RESIDUE H4B A 760 source : AC5 21) chain A residue 478 type sequence Q description BINDING SITE FOR RESIDUE BHH A 831 source : AC6 22) chain A residue 565 type sequence P description BINDING SITE FOR RESIDUE BHH A 831 source : AC6 23) chain A residue 566 type sequence A description BINDING SITE FOR RESIDUE BHH A 831 source : AC6 24) chain A residue 586 type sequence G description BINDING SITE FOR RESIDUE BHH A 831 source : AC6 25) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE BHH A 831 source : AC6 26) chain A residue 592 type sequence E description BINDING SITE FOR RESIDUE BHH A 831 source : AC6 27) chain A residue 676 type sequence W description BINDING SITE FOR RESIDUE H4B B 1760 source : AC8 28) chain A residue 691 type sequence F description BINDING SITE FOR RESIDUE H4B B 1760 source : AC8 29) chain A residue 692 type sequence H description BINDING SITE FOR RESIDUE H4B B 1760 source : AC8 30) chain A residue 693 type sequence Q description BINDING SITE FOR RESIDUE H4B B 1760 source : AC8 31) chain A residue 694 type sequence E description BINDING SITE FOR RESIDUE H4B B 1760 source : AC8 32) chain A residue 334 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 33) chain A residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 34) chain A residue 587 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 35) chain A residue 588 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 36) chain A residue 592 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 37) chain A residue 677 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 38) chain A residue 678 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 39) chain A residue 691 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 40) chain A residue 706 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 41) chain A residue 415 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI2 42) chain A residue 414-421 type prosite sequence RCVGRIQW description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW source prosite : PS60001

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