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eF-site ID
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1lya-ABCD |
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PDB Code
|
1lya |
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Chain
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A, B, C, D |
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click to enlarge
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Title
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CRYSTAL STRUCTURES OF NATIVE AND INHIBITED FORMS OF HUMAN CATHEPSIN D: IMPLICATIONS FOR LYSOSOMAL TARGETING AND DRUG DESIGN |
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Classification
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LYSOSOMAL ASPARTIC PROTEASE |
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Compound
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CATHEPSIN D |
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Source
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ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: Homo sapiens; |
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Sequence
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A: |
GPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLW
VPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGS
GSLSGYLSQDTVSVPCQ
|
| B: |
GGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVN
NVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGG
TDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEG
CEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPC
EKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSG
FMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEA
A
|
| C: |
GPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLW
VPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGS
GSLSGYLSQDTVSVPCQ
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| D: |
GGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVN
NVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGG
TDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEG
CEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPC
EKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSG
FMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEA
A
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Description
|
(1) |
CATHEPSIN D (E.C.3.4.23.5)
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Functional site
|
|
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1)
|
chain |
B |
| residue |
231 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10094, ECO:0000269|PubMed:8393577
|
| source |
Swiss-Prot : SWS_FT_FI1
|
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2)
|
chain |
D |
| residue |
231 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10094, ECO:0000269|PubMed:8393577
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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3)
|
chain |
B |
| residue |
199 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:8393577
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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4)
|
chain |
D |
| residue |
199 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:8393577
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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5)
|
chain |
B |
| residue |
228-239 |
| type |
prosite |
| sequence |
AIVDTGTSLMVG
|
| description |
ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. AIVDTGTSLMVG
|
| source |
prosite : PS00141
|
|
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6)
|
chain |
A |
| residue |
30-41 |
| type |
prosite |
| sequence |
VVFDTGSSNLWV
|
| description |
ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. AIVDTGTSLMVG
|
| source |
prosite : PS00141
|
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