|
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eF-site ID
|
1lxl-A |
|
PDB Code
|
1lxl |
|
Chain
|
A |
|
click to enlarge
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Title
|
NMR STRUCTURE OF BCL-XL, AN INHIBITOR OF PROGRAMMED CELL DEATH, MINIMIZED AVERAGE STRUCTURE |
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Classification
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APOPTOSIS |
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Compound
|
BCL-XL |
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Source
|
null (BCLX_HUMAN) |
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Sequence
|
A: |
MSMAMSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTE
APEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLD
AREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP
GTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVD
KEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYG
NNAAAESRKGQERLEHHHHHH
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Description
|
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Functional site
|
|
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1)
|
chain |
A |
| residue |
49 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine; by PLK3 => ECO:0000269|PubMed:21840391
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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2)
|
chain |
A |
| residue |
62 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine; by CDK1 => ECO:0000269|PubMed:19917720
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
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3)
|
chain |
A |
| residue |
130-148 |
| type |
prosite |
| sequence |
LFRDGVNWGRIVAFFSFGG
|
| description |
BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFsFGG
|
| source |
prosite : PS01080
|
|
|
4)
|
chain |
A |
| residue |
181-192 |
| type |
prosite |
| sequence |
WIQENGGWDTFV
|
| description |
BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqenGGWDtFV
|
| source |
prosite : PS01258
|
|
|
5)
|
chain |
A |
| residue |
86-100 |
| type |
prosite |
| sequence |
VKQALREAGDEFELR
|
| description |
BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VkqaLReAGDEFELR
|
| source |
prosite : PS01259
|
|
|
6)
|
chain |
A |
| residue |
4-24 |
| type |
prosite |
| sequence |
SNRELVVDFLSYKLSQKGYSW
|
| description |
BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. SNRELVvDFLSYKLSQKGYsW
|
| source |
prosite : PS01260
|
|
|
7)
|
chain |
A |
| residue |
61 |
| type |
SITE |
| sequence |
D
|
| description |
Cleavage; by caspase-1
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|