eF-site ID 1lwc-B PDB Code 1lwc Chain B click to enlarge Title CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE Classification TRANSFERASE Compound HIV-1 REVERSE TRANSCRIPTASE Source Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) (POL_HV1H2) Sequence B:  ETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEG KISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQ DFWIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAF TIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEP FRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKIEELRQHLL RWGPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLV GKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAEL ELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQI YQEPFKNLKTGKYARTNDVKQLTEAVQKITTESIVIWGKT PKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLW YQ Description Functional site 1) chain B residue 13 type sequence K description BINDING SITE FOR RESIDUE PO4 A 1300 source : AC1 2) chain B residue 288 type sequence A description BINDING SITE FOR RESIDUE PO4 A 1301 source : AC2 3) chain B residue 235-252 type ZN_FING sequence HPDKWTVQPIVLPEKDSW description CCHC-type 1 => ECO:0000255|PROSITE-ProRule:PRU00047 source Swiss-Prot : SWS_FT_FI1 4) chain B residue 256-273 type ZN_FING sequence DIQKLVGKLNWASQIYPG description CCHC-type 2 => ECO:0000255|PROSITE-ProRule:PRU00047 source Swiss-Prot : SWS_FT_FI2 5) chain B residue 66 type SITE sequence K description Cis/trans isomerization of proline peptide bond; by human PPIA/CYPA source Swiss-Prot : SWS_FT_FI4 6) chain B residue 208 type SITE sequence H description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 7) chain B residue 285 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 8) chain B residue 238 type SITE sequence K description Cleavage; by viral protease => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 9) chain B residue 271 type SITE sequence Y description Cleavage; by viral protease => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 10) chain B residue 277 type SITE sequence R description Cleavage; by viral protease => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 11) chain B residue 333 type SITE sequence G description Cleavage; by viral protease => ECO:0000305|PubMed:15183348 source Swiss-Prot : SWS_FT_FI7

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